Pharmacology of ARBs (Valsartan)
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Questions and Answers

What is a common adverse effect associated with lipid-soluble B-Blockers?

  • Nightmares (correct)
  • Ankle edema
  • Reflex tachycardia
  • Hypokalemia

In which condition is the combination of Calcium Channel Blockers and B-Blockers contraindicated?

  • Vasodilator use
  • Hypertension
  • Bradycardia (correct)
  • Diabetes

What is the primary pharmacological effect of Dihydropyridines like Nifedipine and Amlodipine?

  • Increase in PVR
  • Cardiac work increase
  • Suppression of heart rate
  • Vascular dilatation (correct)

Which Calcium Channel Blocker is associated with the suppression of cardiac properties like cardiac work and contractility?

<p>Verapamil (B)</p> Signup and view all the answers

What is the primary mechanism of action of thiazide diuretics like Hydrochlorothiazide?

<p>Inhibition of Na/Cl cotransporters (D)</p> Signup and view all the answers

Which pharmacological action of beta-blockers contributes to lowering blood pressure by increasing NO synthesis?

<p>Stimulation of NOS enzyme (C)</p> Signup and view all the answers

Why do all beta-blockers not have vasodilating action?

<p>They block the B2 effect (C)</p> Signup and view all the answers

Which indication is NOT associated with the use of beta-blockers?

<p>Intermittent claudication (D)</p> Signup and view all the answers

Why should beta-blockers be avoided as a first-line treatment for hypertension?

<p>They cause bronchoconstriction (B)</p> Signup and view all the answers

Which pharmacological action is unique to Carvedilol among beta-blockers?

<p>Alpha-1 blocking action (D)</p> Signup and view all the answers

Which of the following statements regarding ARBs is FALSE?

<p>ARBs inhibit angiotensin synthesis. (A)</p> Signup and view all the answers

What is a therapeutic indication for ARBs in addition to hypertension?

<p>Management of chronic kidney disease (B)</p> Signup and view all the answers

Which adverse effect is commonly associated with ACE inhibitors but can be managed by replacing them with ARBs?

<p>Dry cough (D)</p> Signup and view all the answers

Which of the following is a pharmacological action of beta-blockers in lowering blood pressure?

<p>Reduced heart rate (D)</p> Signup and view all the answers

What is a common mechanism of action for calcium channel blockers in managing hypertension?

<p>Prevention of calcium influx into vascular smooth muscle (D)</p> Signup and view all the answers

How do beta-blockers exert their pharmacological effects in the treatment of hypertension?

<p>By inhibiting the synthesis of angiotensin II and decreasing vasoconstriction (D)</p> Signup and view all the answers

Which of the following is an indication for using beta-blockers in hypertensive patients?

<p>Recent myocardial infarction with normal heart function (D)</p> Signup and view all the answers

What is a common adverse effect associated with beta-blockers?

<p>Bradycardia (C)</p> Signup and view all the answers

How do calcium channel blockers exert their mechanism of action in lowering blood pressure?

<p>By blocking calcium entry into vascular smooth muscle cells, causing vasodilation (A)</p> Signup and view all the answers

Which of the following statements is true regarding calcium channel blockers?

<p>They have a direct negative inotropic effect on the heart (B)</p> Signup and view all the answers

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