Pharmacology of ARBs (Valsartan)
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Questions and Answers

What is a common adverse effect associated with lipid-soluble B-Blockers?

  • Nightmares (correct)
  • Ankle edema
  • Reflex tachycardia
  • Hypokalemia
  • In which condition is the combination of Calcium Channel Blockers and B-Blockers contraindicated?

  • Vasodilator use
  • Hypertension
  • Bradycardia (correct)
  • Diabetes
  • What is the primary pharmacological effect of Dihydropyridines like Nifedipine and Amlodipine?

  • Increase in PVR
  • Cardiac work increase
  • Suppression of heart rate
  • Vascular dilatation (correct)
  • Which Calcium Channel Blocker is associated with the suppression of cardiac properties like cardiac work and contractility?

    <p>Verapamil (B)</p> Signup and view all the answers

    What is the primary mechanism of action of thiazide diuretics like Hydrochlorothiazide?

    <p>Inhibition of Na/Cl cotransporters (D)</p> Signup and view all the answers

    Which pharmacological action of beta-blockers contributes to lowering blood pressure by increasing NO synthesis?

    <p>Stimulation of NOS enzyme (C)</p> Signup and view all the answers

    Why do all beta-blockers not have vasodilating action?

    <p>They block the B2 effect (C)</p> Signup and view all the answers

    Which indication is NOT associated with the use of beta-blockers?

    <p>Intermittent claudication (D)</p> Signup and view all the answers

    Why should beta-blockers be avoided as a first-line treatment for hypertension?

    <p>They cause bronchoconstriction (B)</p> Signup and view all the answers

    Which pharmacological action is unique to Carvedilol among beta-blockers?

    <p>Alpha-1 blocking action (D)</p> Signup and view all the answers

    Which of the following statements regarding ARBs is FALSE?

    <p>ARBs inhibit angiotensin synthesis. (A)</p> Signup and view all the answers

    What is a therapeutic indication for ARBs in addition to hypertension?

    <p>Management of chronic kidney disease (B)</p> Signup and view all the answers

    Which adverse effect is commonly associated with ACE inhibitors but can be managed by replacing them with ARBs?

    <p>Dry cough (D)</p> Signup and view all the answers

    Which of the following is a pharmacological action of beta-blockers in lowering blood pressure?

    <p>Reduced heart rate (D)</p> Signup and view all the answers

    What is a common mechanism of action for calcium channel blockers in managing hypertension?

    <p>Prevention of calcium influx into vascular smooth muscle (D)</p> Signup and view all the answers

    How do beta-blockers exert their pharmacological effects in the treatment of hypertension?

    <p>By inhibiting the synthesis of angiotensin II and decreasing vasoconstriction (D)</p> Signup and view all the answers

    Which of the following is an indication for using beta-blockers in hypertensive patients?

    <p>Recent myocardial infarction with normal heart function (D)</p> Signup and view all the answers

    What is a common adverse effect associated with beta-blockers?

    <p>Bradycardia (C)</p> Signup and view all the answers

    How do calcium channel blockers exert their mechanism of action in lowering blood pressure?

    <p>By blocking calcium entry into vascular smooth muscle cells, causing vasodilation (A)</p> Signup and view all the answers

    Which of the following statements is true regarding calcium channel blockers?

    <p>They have a direct negative inotropic effect on the heart (B)</p> Signup and view all the answers

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