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Questions and Answers
What is the mechanism of action of receptor tyrosine kinase inhibitors such as imatinib?
What is the mechanism of action of receptor tyrosine kinase inhibitors such as imatinib?
- They bind to docking sites for downstream signaling proteins
- They inhibit the conversion of testosterone to estradiol
- They bind to tyrosine residues and prevent phosphorylation
- They bind to ATP binding sites and prevent phosphorylation (correct)
What is the common cancer mutation that leads to constitutive phosphorylation and signaling?
What is the common cancer mutation that leads to constitutive phosphorylation and signaling?
- Mutation in the estrogen receptor
- Mutation in the tyrosine residues
- Mutation in the ATP binding site
- Mutation in the receptor tyrosine kinase (correct)
What is the therapeutic priority in breast cancers that express estrogen receptors?
What is the therapeutic priority in breast cancers that express estrogen receptors?
- Inhibition of receptor tyrosine kinase
- Reduction of estrogen production (correct)
- Reduction of testosterone production
- Inhibition of downstream signaling proteins
What is the mechanism of action of aromatase inhibitors such as anastrozole and letrozole?
What is the mechanism of action of aromatase inhibitors such as anastrozole and letrozole?
What is the mechanism of action of selective estrogen receptor modulators (SERMs) such as tamoxifen?
What is the mechanism of action of selective estrogen receptor modulators (SERMs) such as tamoxifen?
What is the mechanism of action of selective estrogen receptor downregulators (SERDs) such as fulvestrant?
What is the mechanism of action of selective estrogen receptor downregulators (SERDs) such as fulvestrant?
What is the mechanism of action of anthracyclines, such as doxorubicin, on DNA?
What is the mechanism of action of anthracyclines, such as doxorubicin, on DNA?
Which of the following is a common side effect of anthracyclines?
Which of the following is a common side effect of anthracyclines?
What is the mechanism of action of microtubular inhibitors, such as vincristine and vinblastine?
What is the mechanism of action of microtubular inhibitors, such as vincristine and vinblastine?
What is the effect of taxanes, such as paclitaxel, on microtubules?
What is the effect of taxanes, such as paclitaxel, on microtubules?
What is the common side effect of taxanes, such as paclitaxel, that requires pre-treatment with antihistamines or corticosteroids?
What is the common side effect of taxanes, such as paclitaxel, that requires pre-treatment with antihistamines or corticosteroids?
Which of the following is NOT a type of microtubular inhibitor?
Which of the following is NOT a type of microtubular inhibitor?
What is the primary mechanism of action of alkylating agents like cyclophosphamide?
What is the primary mechanism of action of alkylating agents like cyclophosphamide?
What is a common side effect of platinum-based compounds like cisplatin?
What is a common side effect of platinum-based compounds like cisplatin?
Which type of anticancer drug works by mimicking essential structures within the cell?
Which type of anticancer drug works by mimicking essential structures within the cell?
What is the primary advantage of using regimens of more than one drug?
What is the primary advantage of using regimens of more than one drug?
Why are alkylating agents often used in combination with other drugs?
Why are alkylating agents often used in combination with other drugs?
What is the mode of administration of cyclophosphamide?
What is the mode of administration of cyclophosphamide?
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