Pharmacology: MIC Analysis of Drug X
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Questions and Answers

What is the wavelength at which the absorbance values were obtained through spectrophotometric analysis?

  • 550 nm
  • 650 nm
  • 350 nm
  • 450 nm (correct)

Which of the following NSAIDs exhibited inhibitory activity against gram-negative E. coli at a MIC of 2.5 mg/mL?

  • Drug X
  • Ibuprofen and Paracetamol (correct)
  • Neither Ibuprofen nor Paracetamol
  • Paracetamol

What is the indication of a ZOI of 0 mm for both concentrations tested?

  • No effect on bacterial growth
  • Lack of antibacterial susceptibility (correct)
  • Partial antibacterial susceptibility
  • Complete antibacterial susceptibility

What is the significance of the MIC values of 2.5 mg/mL and 1.25 mg/mL in the context of the study?

<p>They are the lowest concentrations tested (C)</p> Signup and view all the answers

What can be inferred from the results of the Kirby-Bauer test?

<p>Drug X lacks antibacterial properties against E. coli and S. aureus (A)</p> Signup and view all the answers

What is the purpose of determining the Minimum Inhibitory Concentration (MIC) in the study?

<p>To determine the effectiveness of NSAIDs against bacterial growth (A)</p> Signup and view all the answers

What is the primary purpose of determining the Minimum Inhibitory Concentration (MIC) of Drug X?

<p>To evaluate the antibacterial susceptibility of E.coli and S.aureus (A)</p> Signup and view all the answers

What was the main advantage of using laboratory-grown bacterial strains in the experiment?

<p>It safeguarded against acquiring personal information from human subjects and protected privacy (A)</p> Signup and view all the answers

What is the relationship between the Minimum Inhibitory Concentration (MIC) and the antibacterial susceptibility of E.coli and S.aureus?

<p>A lower MIC indicates higher antibacterial susceptibility (C)</p> Signup and view all the answers

Which of the following NSAIDs was not used in the experiment to determine the Minimum Inhibitory Concentration (MIC)?

<p>Aspirin (C)</p> Signup and view all the answers

What is the purpose of calculating the total sums of squares in the experiment?

<p>To analyze the variance in the experiment (D)</p> Signup and view all the answers

What is the protocol used to determine the Minimum Inhibitory Concentration (MIC) of Drug X?

<p>The protocol established by Baltzar (2017) (D)</p> Signup and view all the answers

What is the relationship between drug concentration and absorbance value in aureus?

<p>Inversely proportional (D)</p> Signup and view all the answers

What is the effect of decreasing drug concentration on E. coli?

<p>Decrease in absorbance value (B)</p> Signup and view all the answers

What do the MIC results of Drug X suggest about its activity against S. aureus and E. coli?

<p>Potential inhibitory activity (A)</p> Signup and view all the answers

What is the effect of increasing Ibuprofen and Paracetamol concentration on S. aureus based on the ZOI results?

<p>Increased susceptibility (B)</p> Signup and view all the answers

What was observed in S. aureus at a MIC of 1.25 mg/mL according to AL-Janabi (2010)?

<p>Increased susceptibility (A)</p> Signup and view all the answers

What was observed in the study by Abd-El-Aziz et al. (2020) regarding Paracetamol?

<p>Increased antibacterial activity (D)</p> Signup and view all the answers

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