30 Questions
Which of the following is NOT a dimension of pain experience?
Motor behavioral dimension
What is the primary function of the descending controls in the pain processing pathway?
Inhibit pain transmission
Which brain region is involved in the top-down processing of pain perception?
Midbrain
What is the primary difference between acute and chronic pain?
Mechanisms underlying pain
What is the function of nociceptors in the pain processing pathway?
Transduce painful stimuli into electrical signals
What is the purpose of asking a patient to rate their pain intensity and unpleasantness?
To quantify the sensory and affective dimensions of pain
What is the primary function of nociceptors in the process of pain?
To respond to noxious stimuli and transduce them into receptor potentials
Which type of fibers are polymodal nociceptors?
Aδ and C fibres
What is the function of the relay neurons in the transmission process of pain?
To relay the message through specific pathways to higher brain centers
What is the relationship between nociceptor input and perceived pain intensity?
There is a variable relationship between the two
What is the function of modulation in the process of pain?
To alter activity in the transmission system
What is the primary function of the dorsal horn in the transmission process of pain?
To receive the message from the primary afferent nociceptor
Which region primarily gives rise to descending noradrenergic projections that exert inhibitory control over spinal neuronal processes?
Locus Coeruleus (LC)
What is the primary difference between acute and chronic pain?
Acute pain serves a biological purpose, while chronic pain does not
What is the result of peripheral sensitization in terms of pain response?
An increased pain response due to an increase in nociceptor activity
Which of the following is a characteristic of chronic pain?
It outlasts the normal time of healing and may arise from psychological states
What is the result of upregulation of new receptors due to peripheral sensitization?
An increase in the pain response due to an increase in nociceptor activity
Which region primarily gives rise to descending serotonergic projections that exert facilitatory and inhibitory control over spinal neuronal processes?
Rostral Ventralmedial Medulla (RVM)
What is a characteristic of peripheral sensitization?
It is restricted to the site of injury
What is the primary difference between central and peripheral sensitization?
The site of pain sensitivity
What is a key feature of central sensitization?
It is a result of changes in the functional status of nociceptive neurons
What is the role of kinases in central sensitization?
They participate in changes in threshold and activation kinetics of AMPA and NMDA receptors
What is a characteristic of pain sensitivity in central sensitization?
It produces pain sensitivity long after the initiating cause
What type of pain is characterized by a lesion or dysfunction of the nervous system?
Neuropathic pain
What is the difference between central and peripheral sensitization in terms of the type of inputs involved?
Central sensitization co-opts novel inputs to nociceptive pathways, including those that do not normally drive them
Which of the following eicosanoids are usually regarded as the most important with respect to the pain producing or enhancing aspects of inflammation?
PGE2 and PGI2
What is the effect of noxious factors on sensory neurone specific VG Na channels?
Increase their activity
What is the reason for not experiencing only numbness in neuropathic pain?
Generation of abnormal pain signals
What is the effect of noxious factors on VG K channels?
Decrease their activity
What type of pain is caused by a lesion or dysfunction of the central nervous system?
Central pain
This quiz reviews the underlying mechanisms of pain, covering sensory discriminative and affective motivational dimensions, nociception, and more. Test your understanding of pain perception and modulation.
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