Pharmacology: Mechanisms of Pain

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Which of the following is NOT a dimension of pain experience?

Cognitive evaluative dimension

Motor behavioral dimension (correct)

Affective motivational dimension

Sensory discriminative dimension

What is the primary function of the descending controls in the pain processing pathway?

Modulate emotional response to pain

Inhibit pain transmission (correct)

Process sensory information from peripheral nerves

Enhance pain perception

Which brain region is involved in the top-down processing of pain perception?

Midbrain (correct)

Brainstem

Cerebellum

Cerebral cortex

What is the primary difference between acute and chronic pain?

Mechanisms underlying pain (D) Signup and view all the answers

What is the function of nociceptors in the pain processing pathway?

Transduce painful stimuli into electrical signals (B) Signup and view all the answers

What is the purpose of asking a patient to rate their pain intensity and unpleasantness?

To quantify the sensory and affective dimensions of pain (D) Signup and view all the answers

What is the primary function of nociceptors in the process of pain?

To respond to noxious stimuli and transduce them into receptor potentials (B) Signup and view all the answers

Which type of fibers are polymodal nociceptors?

Aδ and C fibres (B) Signup and view all the answers

What is the function of the relay neurons in the transmission process of pain?

To relay the message through specific pathways to higher brain centers (C) Signup and view all the answers

What is the relationship between nociceptor input and perceived pain intensity?

There is a variable relationship between the two (C) Signup and view all the answers

What is the function of modulation in the process of pain?

To alter activity in the transmission system (A) Signup and view all the answers

What is the primary function of the dorsal horn in the transmission process of pain?

To receive the message from the primary afferent nociceptor (D) Signup and view all the answers

Which region primarily gives rise to descending noradrenergic projections that exert inhibitory control over spinal neuronal processes?

Locus Coeruleus (LC) (D) Signup and view all the answers

What is the primary difference between acute and chronic pain?

Acute pain serves a biological purpose, while chronic pain does not (C) Signup and view all the answers

What is the result of peripheral sensitization in terms of pain response?

An increased pain response due to an increase in nociceptor activity (D) Signup and view all the answers

Which of the following is a characteristic of chronic pain?

It outlasts the normal time of healing and may arise from psychological states (B) Signup and view all the answers

What is the result of upregulation of new receptors due to peripheral sensitization?

An increase in the pain response due to an increase in nociceptor activity (D) Signup and view all the answers

Which region primarily gives rise to descending serotonergic projections that exert facilitatory and inhibitory control over spinal neuronal processes?

Rostral Ventralmedial Medulla (RVM) (C) Signup and view all the answers

What is a characteristic of peripheral sensitization?

It is restricted to the site of injury (C) Signup and view all the answers

What is the primary difference between central and peripheral sensitization?

The site of pain sensitivity (B) Signup and view all the answers

What is a key feature of central sensitization?

It is a result of changes in the functional status of nociceptive neurons (D) Signup and view all the answers

What is the role of kinases in central sensitization?

They participate in changes in threshold and activation kinetics of AMPA and NMDA receptors (A) Signup and view all the answers

What is a characteristic of pain sensitivity in central sensitization?

It produces pain sensitivity long after the initiating cause (B) Signup and view all the answers

What type of pain is characterized by a lesion or dysfunction of the nervous system?

Neuropathic pain (C) Signup and view all the answers

What is the difference between central and peripheral sensitization in terms of the type of inputs involved?

Central sensitization co-opts novel inputs to nociceptive pathways, including those that do not normally drive them (C) Signup and view all the answers

Which of the following eicosanoids are usually regarded as the most important with respect to the pain producing or enhancing aspects of inflammation?

PGE2 and PGI2 (C) Signup and view all the answers

What is the effect of noxious factors on sensory neurone specific VG Na channels?

Increase their activity (A) Signup and view all the answers

What is the reason for not experiencing only numbness in neuropathic pain?

Generation of abnormal pain signals (B) Signup and view all the answers

What is the effect of noxious factors on VG K channels?

Decrease their activity (A) Signup and view all the answers

What type of pain is caused by a lesion or dysfunction of the central nervous system?

Central pain (B) Signup and view all the answers

Pharmacology: Mechanisms of Pain

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Questions and Answers

Which of the following is NOT a dimension of pain experience?

What is the primary function of the descending controls in the pain processing pathway?

Which brain region is involved in the top-down processing of pain perception?

What is the primary difference between acute and chronic pain?

What is the function of nociceptors in the pain processing pathway?

What is the purpose of asking a patient to rate their pain intensity and unpleasantness?

What is the primary function of nociceptors in the process of pain?

Which type of fibers are polymodal nociceptors?

What is the function of the relay neurons in the transmission process of pain?

What is the relationship between nociceptor input and perceived pain intensity?

What is the function of modulation in the process of pain?

What is the primary function of the dorsal horn in the transmission process of pain?

Which region primarily gives rise to descending noradrenergic projections that exert inhibitory control over spinal neuronal processes?

What is the primary difference between acute and chronic pain?

What is the result of peripheral sensitization in terms of pain response?

Which of the following is a characteristic of chronic pain?

What is the result of upregulation of new receptors due to peripheral sensitization?

Which region primarily gives rise to descending serotonergic projections that exert facilitatory and inhibitory control over spinal neuronal processes?

What is a characteristic of peripheral sensitization?

What is the primary difference between central and peripheral sensitization?

What is a key feature of central sensitization?

What is the role of kinases in central sensitization?

What is a characteristic of pain sensitivity in central sensitization?

What type of pain is characterized by a lesion or dysfunction of the nervous system?

What is the difference between central and peripheral sensitization in terms of the type of inputs involved?

Which of the following eicosanoids are usually regarded as the most important with respect to the pain producing or enhancing aspects of inflammation?

What is the effect of noxious factors on sensory neurone specific VG Na channels?

What is the reason for not experiencing only numbness in neuropathic pain?

What is the effect of noxious factors on VG K channels?

What type of pain is caused by a lesion or dysfunction of the central nervous system?

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