Pharmacology Lecture: Diuretics and Renal Tubules

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10 Questions

What is the effect of inhibiting the Na/Cl cotransporter in the distal convoluted tubule?

Decrease in sodium-calcium exchange at the basolateral membrane

Which diuretic is contraindicated in patients with hyperkalemia?

Potassium-sparing diuretic

What is the duration of action of carbonic anhydrase inhibitors?

Around 10 hours

What is the mechanism of action of osmotics?

Retention of water via osmotic effect

What is the potential adverse effect of Vasopressin V2-receptor antagonists?

Liver injury

Which of the following substances is primarily secreted in the proximal tubule?

Uric acid

Which type of diuretic inhibits the Na/K/2Cl-cotransporter in the ascending loop of Henle?

Loop diuretics

What is the effect of aldosterone on the collecting tubule and duct?

Increased synthesis of Na channels and Na/K-ATPase pumps

Which of the following diuretics has a short duration of action and a high ceiling effect?

Furosemide

Which of the following substances is primarily reabsorbed in the descending loop of Henle?

Water

Test your knowledge on diuretics and the renal tubules, including the proximal tubule, loop of henle, and distal convoluted tubule. This quiz covers the reabsorption and secretion of various substances, including glucose, amino acids, and electrolytes.

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