Pharmacology Lecture: Diuretics and Renal Tubules

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Questions and Answers

What is the effect of inhibiting the Na/Cl cotransporter in the distal convoluted tubule?

  • Increase in calcium reabsorption
  • Decrease in sodium-calcium exchange
  • Increase in calcium excretion
  • Decrease in sodium-calcium exchange at the basolateral membrane (correct)

Which diuretic is contraindicated in patients with hyperkalemia?

  • Potassium-sparing diuretic (correct)
  • Loop diuretic
  • Carbonic anhydrase inhibitor
  • Thiazide diuretic

What is the duration of action of carbonic anhydrase inhibitors?

  • 6-8 hours
  • Around 10 hours (correct)
  • 2-4 hours
  • 10-12 hours

What is the mechanism of action of osmotics?

<p>Retention of water via osmotic effect (B)</p> Signup and view all the answers

What is the potential adverse effect of Vasopressin V2-receptor antagonists?

<p>Liver injury (A)</p> Signup and view all the answers

Which of the following substances is primarily secreted in the proximal tubule?

<p>Uric acid (B)</p> Signup and view all the answers

Which type of diuretic inhibits the Na/K/2Cl-cotransporter in the ascending loop of Henle?

<p>Loop diuretics (C)</p> Signup and view all the answers

What is the effect of aldosterone on the collecting tubule and duct?

<p>Increased synthesis of Na channels and Na/K-ATPase pumps (C)</p> Signup and view all the answers

Which of the following diuretics has a short duration of action and a high ceiling effect?

<p>Furosemide (B)</p> Signup and view all the answers

Which of the following substances is primarily reabsorbed in the descending loop of Henle?

<p>Water (C)</p> Signup and view all the answers

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