Pharmacology Lecture: Diuretics and Renal Tubules
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Questions and Answers

What is the effect of inhibiting the Na/Cl cotransporter in the distal convoluted tubule?

  • Increase in calcium reabsorption
  • Decrease in sodium-calcium exchange
  • Increase in calcium excretion
  • Decrease in sodium-calcium exchange at the basolateral membrane (correct)
  • Which diuretic is contraindicated in patients with hyperkalemia?

  • Potassium-sparing diuretic (correct)
  • Loop diuretic
  • Carbonic anhydrase inhibitor
  • Thiazide diuretic
  • What is the duration of action of carbonic anhydrase inhibitors?

  • 6-8 hours
  • Around 10 hours (correct)
  • 2-4 hours
  • 10-12 hours
  • What is the mechanism of action of osmotics?

    <p>Retention of water via osmotic effect</p> Signup and view all the answers

    What is the potential adverse effect of Vasopressin V2-receptor antagonists?

    <p>Liver injury</p> Signup and view all the answers

    Which of the following substances is primarily secreted in the proximal tubule?

    <p>Uric acid</p> Signup and view all the answers

    Which type of diuretic inhibits the Na/K/2Cl-cotransporter in the ascending loop of Henle?

    <p>Loop diuretics</p> Signup and view all the answers

    What is the effect of aldosterone on the collecting tubule and duct?

    <p>Increased synthesis of Na channels and Na/K-ATPase pumps</p> Signup and view all the answers

    Which of the following diuretics has a short duration of action and a high ceiling effect?

    <p>Furosemide</p> Signup and view all the answers

    Which of the following substances is primarily reabsorbed in the descending loop of Henle?

    <p>Water</p> Signup and view all the answers

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