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Questions and Answers
Which of the following is the primary mechanism of resistance to penicillins and other β-lactam antibiotics?
Which of the following is the primary mechanism of resistance to penicillins and other β-lactam antibiotics?
- Inactivation of the antibiotic by β-lactamase (correct)
- Antibiotic efflux
- Impaired penetration of the drug to the target PBPs
- Modification of target penicillin-binding proteins (PBPs)
Which of the following is a key characteristic of the mechanism of action of penicillins?
Which of the following is a key characteristic of the mechanism of action of penicillins?
- They are effective against both rapidly growing and slow-growing organisms
- They are active against mycobacteria and viruses
- They interfere with bacterial cell wall synthesis by inhibiting transpeptidation or cross-linkage (correct)
- They are bacteriostatic and work in a concentration-dependent fashion
Which class of penicillins is resistant to staphylococcal β-lactamases?
Which class of penicillins is resistant to staphylococcal β-lactamases?
- Extended-spectrum penicillins
- Antistaphylococcal penicillins (correct)
- Antipseudomonal penicillins
- Aminopenicillins
What is the primary difference between penicillins and extended-spectrum penicillins?
What is the primary difference between penicillins and extended-spectrum penicillins?
Which of the following is true about the bactericidal activity of penicillins?
Which of the following is true about the bactericidal activity of penicillins?
Which of the following β-lactam antibiotics has improved activity against Gram-negative rods compared to penicillin?
Which of the following β-lactam antibiotics has improved activity against Gram-negative rods compared to penicillin?
How do penicillins exert their bactericidal effect?
How do penicillins exert their bactericidal effect?
Which of the following is a key characteristic of antistaphylococcal penicillins?
Which of the following is a key characteristic of antistaphylococcal penicillins?
What is the primary reason why penicillins are inactive against organisms devoid of a peptidoglycan cell wall?
What is the primary reason why penicillins are inactive against organisms devoid of a peptidoglycan cell wall?
Which of the following is a common mechanism of resistance to penicillins and other β-lactam antibiotics?
Which of the following is a common mechanism of resistance to penicillins and other β-lactam antibiotics?
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