Pharmacology Key Concepts

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Questions and Answers

What is the primary focus of pharmacology?

  • Study of the human body
  • Study of chemical reactions
  • Study of diseases
  • Study of drugs (correct)

Which of the following is NOT a part of pharmacokinetics?

  • Mechanism of action (correct)
  • Metabolism
  • Absorption
  • Distribution

What does pharmacodynamics study?

  • What the drug does to the body (correct)
  • The excretion of drugs
  • The formulation of drugs
  • What the body does to the drug

Which drug increases gastric emptying and thus increases the absorption of paracetamol?

<p>Metoclopramide (A)</p>
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What is the effect of gastric acidity on the absorption of weak acids?

<p>Increases absorption (A)</p>
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Which of the following drugs can chelate tetracyclines?

<p>Ferrous salts (C)</p>
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What is the primary site of drug metabolism in the body?

<p>Liver (D)</p>
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Which of the following is an example of a Phase I biotransformation reaction?

<p>Oxidation (C)</p>
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Which of the following drugs is known to induce hepatic microsomal enzymes?

<p>Rifampicin (D)</p>
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What is the main route of drug excretion?

<p>Renal (A)</p>
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Which of the following factors does NOT affect drug absorption?

<p>Blood volume (D)</p>
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What is the bioavailability of a drug administered intravenously?

<p>100% (B)</p>
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Which of the following is an example of a drug that undergoes first-pass hepatic metabolism?

<p>Propranolol (B)</p>
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Which of the following is NOT a mode of drug transport across cell membranes?

<p>Osmosis (C)</p>
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What is the primary protein to which drugs bind in the plasma?

<p>Albumin (D)</p>
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Which of the following drugs is known to cause hypoglycemia when displaced from plasma protein binding sites?

<p>Tolbutamide (C)</p>
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What is the primary effect of enzyme inducers on drug metabolism?

<p>Increase metabolism (D)</p>
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Which of the following is an example of a drug that is excreted in the bile in an active form?

<p>Ampicillin (B)</p>
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What is the primary mechanism of action of guanethidine?

<p>Decreases neuronal release of norepinephrine (D)</p>
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Which of the following drugs is known to increase the nephrotoxicity of cephaloridine?

<p>Frusemide (A)</p>
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Flashcards

Pharmacology

The study of drugs, including their actions and effects on living systems.

Pharmacokinetics

The processes of absorption, distribution, metabolism, and excretion of a drug in the body.

Mechanism of Action

The mechanism of a drug's action.

Pharmacodynamics

The study of the biochemical and physiological effects of drugs on the body.

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Metoclopramide

Increases gastric emptying, leading to increased paracetamol absorption.

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Gastric Acidity Effect

Gastric acidity increases the absorption of weak acids.

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Chelating drugs

Drugs that can bind to tetracyclines, reducing their absorption.

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Primary drug metabolism site

Liver

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Phase I Biotransformation Reaction

Oxidation

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Rifampicin

A drug that induces hepatic microsomal enzymes.

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Main route of drug excretion

Renal (Kidney)

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Blood volume on drug absorption

Does NOT affect drug absorption.

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Bioavailability of Intravenous Drug

100%

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Drug w/ First-Pass Hepatic Metabolism

Propranolol

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Not a Drug Transport Mode

Osmosis

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Primary plasma protein for drug binding

Albumin

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Drug & Hypoglycemia

Tolbutamide

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Enzyme inducers effect on drug metabolism

Increase metabolism

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Drug Excreted in Bile (Active)

Ampicillin

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Guanethidine's Action

Decrease Neuronal Norepinephrine

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Drug increase nephrotoxicity

Frusemide

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Study Notes

  • Pharmacology primarily focuses on the study of drugs.
  • Mechanism of action is not a part of pharmacokinetics.
  • Pharmacodynamics studies what the drug does to the body.
  • The drug Metoclopramide increases gastric emptying, increasing paracetamol absorption.
  • Gastric acidity increases the absorption of weak acids.
  • Ferrous salts chelate tetracyclines.
  • The liver is the primary site of drug metabolism in the body.
  • Oxidation is an example of a Phase I biotransformation reaction.
  • Rifampicin induces hepatic microsomal enzymes.
  • Renal excretion is the main route of drug excretion.
  • Blood volume does not affect drug absorption.
  • A drug administered intravenously has 100% bioavailability.
  • Propranolol undergoes first-pass hepatic metabolism.
  • Osmosis is not a mode of drug transport across cell membranes.
  • Albumin is the primary protein to which drugs bind in the plasma.
  • Tolbutamide is known to cause hypoglycemia when displaced from plasma protein binding sites.
  • Enzyme inducers primarily increase drug metabolism.
  • Ampicillin is excreted in the bile in an active form.
  • Guanethidine primarily decreases neuronal release of norepinephrine.
  • Frusemide increases the nephrotoxicity of cephaloridine.

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