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Pharmacology II: Antidepressant Drugs

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Questions and Answers

What is the primary mechanism by which antidepressants exert their therapeutic effect?

Decreasing the levels of monoamine oxidase

Increasing the release of neurotransmitters from presynaptic neurons

Preventing the reuptake of dopamine, norepinephrine, and serotonin by presynaptic neurons (correct)

Blocking the action of acetylcholine

Which of the following antidepressants is classified as a Mood-Stabilizing Agent?

Phenelzine

Citalopram

Lithium carbonate (correct)

Amitriptyline

What is a common side effect of tricyclic antidepressants?

Sedation (correct)

Weight loss

Insomnia

Anxiety

Which of the following conditions is NOT a listed use of antidepressant drugs?

Hypertension Signup and view all the answers

What is the action of tricyclic antidepressants on acetylcholine?

They block the action of acetylcholine Signup and view all the answers

What is the primary use of lithium carbonate in treating bipolar disorder?

To treat and prevent manic episodes Signup and view all the answers

Why are baseline studies of renal, cardiac, and thyroid status necessary before starting lithium therapy?

Because adverse drug effects involve these organ systems Signup and view all the answers

What should the patient be advised to do if they experience dry mouth while taking lithium carbonate?

Rinse their mouth frequently and practice good oral hygiene Signup and view all the answers

What should the patient be cautioned to avoid when taking lithium carbonate?

Driving and other activities requiring alertness Signup and view all the answers

Why should patients receiving MAO inhibitors avoid certain foods and beverages?

Because they contain tyramine Signup and view all the answers

What is the primary way that tricyclic antidepressants alleviate depression?

By restoring the balance of neurotransmitters in the brain Signup and view all the answers

What is a common adverse effect of Selective Serotonin Reuptake Inhibitors (SSRIs)?

Gastrointestinal symptoms Signup and view all the answers

Why are Monoamine Oxidase Inhibitors (MAOIs) infrequently used?

They may interact with certain foods and drugs to produce severe hypertension Signup and view all the answers

What is the result of tyramine absorption when deactivation is blocked by MAOIs?

A sudden release of large amounts of norepinephrine Signup and view all the answers

What type of food should be avoided when taking MAOIs?

Aged cheeses and meats Signup and view all the answers