Pharmacology Foundations
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Questions and Answers

State the difference between hypoventilation and hyperventilation in terms of breathing rate.

Hypoventilation involves breathing slow, while hyperventilation involves breathing fast.

What does hypoxia refer to?

  • Breathing slow
  • Not enough oxygen in the tissue (correct)
  • Breathing fast
  • Not enough oxygen in the blood
  • Impaired valvular function can affect a patient's breathing.

    True

    Myocardial ischemia is caused by dead tissue in the heart due to a lack of ________.

    <p>oxygen</p> Signup and view all the answers

    What is the primary purpose of pharmacokinetics in the body?

    <p>To move drugs through the body</p> Signup and view all the answers

    Define what 'Enteral' and 'Parenteral' routes refer to in drug absorption.

    <p>Enteral refers to absorption through the gastrointestinal tract, while Parenteral refers to absorption outside the GI tract.</p> Signup and view all the answers

    Metabolism of drugs involves chemical alterations to facilitate their removal from the body.

    <p>True</p> Signup and view all the answers

    Drugs are primarily excreted from the body through the _________ system.

    <p>kidneys</p> Signup and view all the answers

    Match the following drug response terms with their definitions:

    <p>Minimum effective concentration (MEC) = The plasma drug level at which effects occur Therapeutic effect = The expected response caused by medication Peak = The highest drug level shortly after administration Trough = The lowest drug level before the next dose Duration = The time a drug remains at a concentration sufficient for response</p> Signup and view all the answers

    What is the term for breathing slow?

    <p>Hypoventilation</p> Signup and view all the answers

    What does hypoxemia refer to?

    <p>Not enough oxygen in the blood</p> Signup and view all the answers

    What is ischemia?

    <p>Dead tissue</p> Signup and view all the answers

    Elderly individuals and babies are not affected by age when it comes to oxygenation.

    <p>False</p> Signup and view all the answers

    ______ is the term used for oxygen saturation on a pulse oximeter.

    <p>SpO2</p> Signup and view all the answers

    What are the three main names used to identify a drug according to the context provided?

    <p>Chemical, Generic, Brand</p> Signup and view all the answers

    IV administration is known for its rapid onset and immediate absorption into the bloodstream.

    <p>True</p> Signup and view all the answers

    What is the primary site for almost all drug excretion in the body?

    <p>kidneys</p> Signup and view all the answers

    Dissolution rate affects the _______ of a drug.

    <p>absorption</p> Signup and view all the answers

    Match the drug administration route with its characteristics:

    <p>Intramuscular (IM) = Can be absorbed rapidly or slowly, depending on the drug's purpose Subcutaneous (SQ) = Minimal barriers, absorption can be depot-like for long-term effect Oral (PO) = Variable absorption affected by factors like solubility, stability, and food intake</p> Signup and view all the answers

    Study Notes

    Foundations of Medications

    • Medication Administration: Give the right drug to the right patient in the right dose by the right route at the right time.

    Chemical, Generic, and Trade/Brand Names

    • Chemical Name: Describes the molecular structure (e.g., Acetylsalicylic acid)
    • Generic Name: Name given by the manufacturer (e.g., aspirin)
    • Trade/Brand Name: Name marketed by the manufacturer (e.g., Bayer)

    Pharmacokinetics

    • Absorption: Movement of drugs into the bloodstream through various routes (e.g., IV, PO, IM, SQ)
    • Distribution: Movement of drugs from the bloodstream to tissues and cells
    • Metabolism: Breaking down of drugs in the body
    • Excretion: Elimination of drugs from the body

    Absorption Routes

    IV (Intravenous)

    • Advantages: No barriers, instantaneous absorption, rapid onset (15-30 minutes), and can give large fluid volumes
    • Disadvantages: Requires special training, expensive, irreversible, and risks embolism and blood clotting

    IM (Intramuscular) and SQ (Subcutaneous)

    • Advantages: Minimal barriers, rapid or slow absorption, and can administer depot drugs for long-term absorption
    • Disadvantages: Painful, inconvenient, volume limits, and not suitable for patients on anticoagulant therapy

    PO (Oral)

    • Advantages: Convenient, safer, easy, and retrievable in cases of overdose
    • Disadvantages: Highly variable absorption, affected by food, gastric emptying, and pH levels

    Distribution

    • Factors Affecting Distribution: Blood flow, surface area, and lipid solubility
    • Blood-Brain Barrier: Tight junctures in the brain limit drug distribution
    • Metabolism: Chemical alteration of drugs in the body

    Metabolism

    • First-Pass Effect: Inactivation of oral drugs through liver metabolism
    • Prodrugs: Creation of drugs through metabolism
    • Nutritional Status: Effects of malnutrition on metabolic enzymes
    • Age: Effects of age on metabolism
    • Competition between drugs: Interactions between multiple drugs

    Excretion

    • Renal Excretion: Majority of drug elimination occurs in the kidneys
    • Non-Renal Excretion: Drug elimination through bile, breast milk, sweat, and saliva

    Drug Response

    • Onset: Time it takes for a drug to produce a response
    • Minimum Effective Concentration (MEC): Plasma drug level required for a therapeutic effect
    • Therapeutic Effect: Expected response caused by a drug
    • Peak: Highest plasma drug level
    • Trough: Lowest plasma drug level
    • Duration: Time the drug is present in the system at a concentration high enough for a response
    • Plateau: Steady drug level after repeated doses
    • Toxic Concentration: Level at which toxic effects occur

    Time Course of Drug Responses

    • Half-Life: Time for the drug concentration to decrease by 50%
    • Loading Dose: Initial large dose to quickly achieve a therapeutic effect
    • Maintenance Dose: Repeated doses to maintain a therapeutic level

    Foundations of Medications

    • Medication Administration: Give the right drug to the right patient in the right dose by the right route at the right time.

    Chemical, Generic, and Trade/Brand Names

    • Chemical Name: Describes the molecular structure (e.g., Acetylsalicylic acid)
    • Generic Name: Name given by the manufacturer (e.g., aspirin)
    • Trade/Brand Name: Name marketed by the manufacturer (e.g., Bayer)

    Pharmacokinetics

    • Absorption: Movement of drugs into the bloodstream through various routes (e.g., IV, PO, IM, SQ)
    • Distribution: Movement of drugs from the bloodstream to tissues and cells
    • Metabolism: Breaking down of drugs in the body
    • Excretion: Elimination of drugs from the body

    Absorption Routes

    IV (Intravenous)

    • Advantages: No barriers, instantaneous absorption, rapid onset (15-30 minutes), and can give large fluid volumes
    • Disadvantages: Requires special training, expensive, irreversible, and risks embolism and blood clotting

    IM (Intramuscular) and SQ (Subcutaneous)

    • Advantages: Minimal barriers, rapid or slow absorption, and can administer depot drugs for long-term absorption
    • Disadvantages: Painful, inconvenient, volume limits, and not suitable for patients on anticoagulant therapy

    PO (Oral)

    • Advantages: Convenient, safer, easy, and retrievable in cases of overdose
    • Disadvantages: Highly variable absorption, affected by food, gastric emptying, and pH levels

    Distribution

    • Factors Affecting Distribution: Blood flow, surface area, and lipid solubility
    • Blood-Brain Barrier: Tight junctures in the brain limit drug distribution
    • Metabolism: Chemical alteration of drugs in the body

    Metabolism

    • First-Pass Effect: Inactivation of oral drugs through liver metabolism
    • Prodrugs: Creation of drugs through metabolism
    • Nutritional Status: Effects of malnutrition on metabolic enzymes
    • Age: Effects of age on metabolism
    • Competition between drugs: Interactions between multiple drugs

    Excretion

    • Renal Excretion: Majority of drug elimination occurs in the kidneys
    • Non-Renal Excretion: Drug elimination through bile, breast milk, sweat, and saliva

    Drug Response

    • Onset: Time it takes for a drug to produce a response
    • Minimum Effective Concentration (MEC): Plasma drug level required for a therapeutic effect
    • Therapeutic Effect: Expected response caused by a drug
    • Peak: Highest plasma drug level
    • Trough: Lowest plasma drug level
    • Duration: Time the drug is present in the system at a concentration high enough for a response
    • Plateau: Steady drug level after repeated doses
    • Toxic Concentration: Level at which toxic effects occur

    Time Course of Drug Responses

    • Half-Life: Time for the drug concentration to decrease by 50%
    • Loading Dose: Initial large dose to quickly achieve a therapeutic effect
    • Maintenance Dose: Repeated doses to maintain a therapeutic level

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    Description

    Learn about the basics of pharmacology, including the types of drug names, pharmacokinetics, and the importance of correct administration. Understand the differences between chemical, generic, and trade names, and how drugs move through the body.

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