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Questions and Answers
What is the primary goal of homeostasis?
What is the primary goal of homeostasis?
Which physiological variable does NOT have a specific normal range mentioned?
Which physiological variable does NOT have a specific normal range mentioned?
What happens when a homeostatic mechanism fails for one variable?
What happens when a homeostatic mechanism fails for one variable?
Which of the following best describes the dynamic nature of homeostasis?
Which of the following best describes the dynamic nature of homeostasis?
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What factors regulate homeostasis in the body?
What factors regulate homeostasis in the body?
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How does the body respond when normal physiological responses are altered?
How does the body respond when normal physiological responses are altered?
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Which of these substances is considered hydrophobic?
Which of these substances is considered hydrophobic?
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What is a key component that must be regulated for normal cellular function?
What is a key component that must be regulated for normal cellular function?
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What happens to protein structure when exposed to heat and extreme pH?
What happens to protein structure when exposed to heat and extreme pH?
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How is pH mathematically defined in relation to hydrogen ion concentration?
How is pH mathematically defined in relation to hydrogen ion concentration?
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Which of the following statements is true regarding acidity and hydrogen ion concentration?
Which of the following statements is true regarding acidity and hydrogen ion concentration?
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What normally describes the pH of intracellular fluid (ICF)?
What normally describes the pH of intracellular fluid (ICF)?
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What is the definition of an acid in terms of its behavior in solution?
What is the definition of an acid in terms of its behavior in solution?
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What is the primary result of diffusion in a liquid or gas?
What is the primary result of diffusion in a liquid or gas?
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How does osmosis differ from diffusion?
How does osmosis differ from diffusion?
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What does the rate of diffusion depend on?
What does the rate of diffusion depend on?
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What is meant by dynamic equilibrium in cellular homeostasis?
What is meant by dynamic equilibrium in cellular homeostasis?
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What role does the electrochemical potential play in the equilibrium of living cells?
What role does the electrochemical potential play in the equilibrium of living cells?
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Which statement best describes the semi-permeable membrane's function in osmosis?
Which statement best describes the semi-permeable membrane's function in osmosis?
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What can result from an alteration in concentration gradients in living organisms?
What can result from an alteration in concentration gradients in living organisms?
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Which of the following best explains the relationship between concentration gradients and hydrostatic pressure during equilibrium?
Which of the following best explains the relationship between concentration gradients and hydrostatic pressure during equilibrium?
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What do cells combat to maintain concentration gradients?
What do cells combat to maintain concentration gradients?
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What is the osmolarity concentration range for human intracellular fluid (ICF)?
What is the osmolarity concentration range for human intracellular fluid (ICF)?
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What happens to red blood cells (RBCs) placed in a hypertonic solution?
What happens to red blood cells (RBCs) placed in a hypertonic solution?
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What does the term 'osmolarity' relate to?
What does the term 'osmolarity' relate to?
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What is the primary role of cells in maintaining electrochemical equilibrium?
What is the primary role of cells in maintaining electrochemical equilibrium?
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What effect does the administration of hypertonic solutions have on cells?
What effect does the administration of hypertonic solutions have on cells?
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During equilibrium, what occurs in terms of water or molecule movement?
During equilibrium, what occurs in terms of water or molecule movement?
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Which process refers to the assisted movement of some molecules through the cell membrane?
Which process refers to the assisted movement of some molecules through the cell membrane?
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What characterizes a strong acid compared to a weak acid?
What characterizes a strong acid compared to a weak acid?
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What do hydrophilic substances have that allows them to dissolve in water?
What do hydrophilic substances have that allows them to dissolve in water?
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What role does negative feedback play in biological systems?
What role does negative feedback play in biological systems?
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What occurs when molecular charge is altered?
What occurs when molecular charge is altered?
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What defines hydrophobic substances?
What defines hydrophobic substances?
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How do enzymes typically respond to pH changes?
How do enzymes typically respond to pH changes?
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What is produced when carbonic acid dissociates?
What is produced when carbonic acid dissociates?
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What happens to small changes in hydrogen ion concentration?
What happens to small changes in hydrogen ion concentration?
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What is the primary role of negative feedback in physiological processes?
What is the primary role of negative feedback in physiological processes?
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Which hormone released during negative feedback decreases blood glucose levels?
Which hormone released during negative feedback decreases blood glucose levels?
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In the context of positive feedback, what initiates uterine contraction during labor?
In the context of positive feedback, what initiates uterine contraction during labor?
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Which of the following best describes the nature of positive feedback?
Which of the following best describes the nature of positive feedback?
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What is the function of glucagon in relation to blood glucose levels?
What is the function of glucagon in relation to blood glucose levels?
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Which physiological response is involved in the negative feedback mechanism to lower blood glucose?
Which physiological response is involved in the negative feedback mechanism to lower blood glucose?
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What is an example of a physiological process governed by positive feedback?
What is an example of a physiological process governed by positive feedback?
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Which type of feedback mechanism is more commonly found in physiological processes?
Which type of feedback mechanism is more commonly found in physiological processes?
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Flashcards
Homeostasis
Homeostasis
Maintaining a stable internal environment despite external changes.
Homeostatic Variables
Homeostatic Variables
Physiological factors (like glucose, oxygen, pH) that need to stay within a specific range for healthy cellular function.
Dynamic Constancy
Dynamic Constancy
Homeostatic variables fluctuate within a narrow range, but are not perfectly constant over time.
ECF and ICF
ECF and ICF
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Homeostasis Regulation
Homeostasis Regulation
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Normal Cellular Function
Normal Cellular Function
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Homeostatic Failure
Homeostatic Failure
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Drug Administration
Drug Administration
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Cellular Homeostasis
Cellular Homeostasis
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Electrochemical Potential
Electrochemical Potential
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Diffusion
Diffusion
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Diffusion Rate
Diffusion Rate
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Semi-permeable Membrane
Semi-permeable Membrane
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Osmosis
Osmosis
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Dynamic Equilibrium
Dynamic Equilibrium
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Concentration Gradient
Concentration Gradient
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Transport across cell membrane
Transport across cell membrane
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Equilibrium (in cells)
Equilibrium (in cells)
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Osmolarity
Osmolarity
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Human ICF osmolarity
Human ICF osmolarity
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Hypertonic solution
Hypertonic solution
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Hypotonic solution
Hypotonic solution
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Isotonic solution
Isotonic solution
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Protein Structure
Protein Structure
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Protein as Enzymes
Protein as Enzymes
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Acidity of a solution
Acidity of a solution
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pH scale
pH scale
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Hydrogen Ion (H+)
Hydrogen Ion (H+)
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Carbonic Acid
Carbonic Acid
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Bicarbonate
Bicarbonate
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Strong Acid
Strong Acid
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Weak Acid
Weak Acid
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Hydrophilic
Hydrophilic
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Hydrophobic
Hydrophobic
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Negative Feedback
Negative Feedback
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Enzyme Activity and pH
Enzyme Activity and pH
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Positive Feedback
Positive Feedback
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Insulin
Insulin
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Glucagon
Glucagon
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Parturition
Parturition
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Oxytocin
Oxytocin
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Drug Dose
Drug Dose
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Contraindication
Contraindication
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Study Notes
Pharmacology for EMS - Week 2: Introduction to Homeostasis
-
Objectives:
- Describe homeostasis and transport mechanisms for normal cellular function
- Discuss properties of hydrophilic and hydrophobic substances
- Describe protein synthesis and protein roles in the body
- Describe enzyme role and function
- Describe and give examples of positive and negative feedback mechanisms
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Homeostasis:
- Maintaining a stable internal environment despite external stressors
- A dynamic process, not constant over time (e.g., temperature, pH, glucose levels)
- Considered individually for each physiological variable
- Homeostatic failure in one variable can affect others
- Regulated by control systems (feedback mechanisms, reflexes, hormones, chemical messengers, biological rhythms)
- Cells have specific requirements or "normal ranges" for glucose, oxygen, salts, pH, waste products, and temperature (e.g., temperature 36.5-37.5°C, pH 7.35-7.45)
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Drug Administration and Homeostasis:
- Administering drugs implies the body's homeostatic and feedback mechanisms are not functioning correctly
- Drugs are administered exogenously (from outside the body) to intervene
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Transport:
- Cells maintain electrical and chemical differences between intracellular and extracellular environments to allow reaction and interaction
- Maintaining concentration gradients in cells requires a constant battle against diffusion
- Some molecules easily pass through cell membranes; others need assistance (facilitated diffusion), or active transport against concentration gradients
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Equilibrium:
- Cells maintain osmolarity and electrochemical equilibrium between the extracellular fluid (ECF) and intracellular fluid (ICF) with no net movement of water or molecules under normal conditions.
- There is a difference in ion concentration and an electrochemical charge due to active transport into and out of cells
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Diffusion:
- All molecules are constantly vibrating
- Higher energy state leads to more movement
- Diffusion results in even distribution of molecules within a container until concentration is uniform in the container
- The rate of diffusion is related to concentration differences between compartments
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Diffusion in Living Organisms:
- Essential for processes like oxygen, carbon dioxide, salt, ion, and glucose diffusion
- Complicated pathology or drug action often results from altered concentration gradients or impaired diffusion at the molecular level
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Diffusion Across a Semi-Permeable Membrane:
- Osmosis is water diffusion from low solute concentration to high solute concentration through a semipermeable membrane.
- Equilibrium occurs when competing forces of concentration (osmotic) gradient and hydrostatic pressure are in balance
- Electrochemical potential difference also considered for equilibrium
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Transport across cell membranes:
-Cells maintain concentration gradients despite continuous diffusion -
Enzymes:
- Proteins that act as catalysts, lowering activation energy for chemical reactions
- Not consumed by reactions, allowing repeated use with additional substrates
- Subject to specificity, affinity, competition, and saturation in their binding
- Accelerate both forward and reverse chemical reactions
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Enzymes and Drug Metabolism:
- Most drugs are metabolized or modified by enzymes
- Common mechanisms of drug action include altered enzyme induction/inhibition or kinetics. This will be discussed in greater detail in future lectures
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Proteins:
- Involved in all physiological processes; Some are enzymes
- Receptors can be regulated
- Protein structure is not static, and changes in structure affect protein properties
- Protein structure can be affected by heat and extremes in pH
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Hydrogen Ions, pH, and Acidity:
- pH measures acidity/basicity (lower pH means more acidic)
- Pure water pH = 7.0
- ICF pH ~ 7.0-7.2 and ECF pH ~ 7.35-7.45
- Acidity refers to free/unbound hydrogen ion concentration
- Hydrogen ion concentration is expressed as a negative log Small changes in pH can have a large effect on molecular interactions
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Feedback Mechanisms:
- Positive feedback leads to accelerating amplification of initial stimulus.
- Negative feedback leads to the inhibition of further reaction
- Negative feedback regulates homeostasis
- Most physiological processes use negative feedback to maintain physiological properties and concentrations within narrow ranges.
- Drugs can affect the body's natural feedback mechanisms
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Drugs Revision for Week 3:
- Study ibuprofen, paracetamol, and Entonox with emphasis on dose, presentation, indications, and contraindications
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Description
This quiz covers the essential concepts of homeostasis related to pharmacology for emergency medical services. Key topics include transport mechanisms, properties of substances, protein synthesis, enzyme functions, and feedback mechanisms. Understanding these principles is crucial for maintaining a stable internal environment in medical practice.