Podcast
Questions and Answers
Through which primary route is cyclophosphamide excreted?
Through which primary route is cyclophosphamide excreted?
Kidneys
Which part of the cell does fluorouracil affect during the S phase of the cell cycle?
Which part of the cell does fluorouracil affect during the S phase of the cell cycle?
DNA
Which type of chemotherapy refers to chemotherapeutic drugs packaged in a fat globule?
Which type of chemotherapy refers to chemotherapeutic drugs packaged in a fat globule?
Liposomal
Which statement is accurate regarding tamoxifen?
Which statement is accurate regarding tamoxifen?
Signup and view all the answers
During which time frame will anti-emetic therapy be most beneficial to J.W. before administering cyclophosphamide?
During which time frame will anti-emetic therapy be most beneficial to J.W. before administering cyclophosphamide?
Signup and view all the answers
Which location would the nurse prepare chemotherapeutic drugs before administration?
Which location would the nurse prepare chemotherapeutic drugs before administration?
Signup and view all the answers
Which chemotherapeutic agent would the nurse expect to administer for Philadelphia chromosome-negative acute lymphoblastic leukemia?
Which chemotherapeutic agent would the nurse expect to administer for Philadelphia chromosome-negative acute lymphoblastic leukemia?
Signup and view all the answers
CYP2D6 inducers have which effect on chemotherapeutic drugs?
CYP2D6 inducers have which effect on chemotherapeutic drugs?
Signup and view all the answers
Match the chemotherapeutic drug to its class.
Match the chemotherapeutic drug to its class.
Signup and view all the answers
In which phase of the cell cycle do most antimetabolites affect cells?
In which phase of the cell cycle do most antimetabolites affect cells?
Signup and view all the answers
A patient with multiple myeloma received cyclophosphamide at 0900. Which time would the nurse expect the drug to peak?
A patient with multiple myeloma received cyclophosphamide at 0900. Which time would the nurse expect the drug to peak?
Signup and view all the answers
What are the benefits of treating cancer cells with a combination of different classes of chemotherapeutic drugs?
What are the benefits of treating cancer cells with a combination of different classes of chemotherapeutic drugs?
Signup and view all the answers
Why must vincristine be given intravenously?
Why must vincristine be given intravenously?
Signup and view all the answers
What should the nurse do if a patient with plant allergies is prescribed vincristine?
What should the nurse do if a patient with plant allergies is prescribed vincristine?
Signup and view all the answers
Which statement made by the patient indicates a need for further teaching regarding doxorubicin?
Which statement made by the patient indicates a need for further teaching regarding doxorubicin?
Signup and view all the answers
What action should a nurse take to decrease the risk for occupational exposure when disposing of urine from a patient receiving chemotherapeutic drugs?
What action should a nurse take to decrease the risk for occupational exposure when disposing of urine from a patient receiving chemotherapeutic drugs?
Signup and view all the answers
What should the nurse do first when a patient is prescribed oral cyclophosphamide 700 mg and weighs 125 pounds?
What should the nurse do first when a patient is prescribed oral cyclophosphamide 700 mg and weighs 125 pounds?
Signup and view all the answers
What product would the nurse anticipate administering due to a significant drop in neutrophils?
What product would the nurse anticipate administering due to a significant drop in neutrophils?
Signup and view all the answers
A patient receiving chemotherapeutic drugs complains of mouth lesions. Which drug would the nurse most likely provide?
A patient receiving chemotherapeutic drugs complains of mouth lesions. Which drug would the nurse most likely provide?
Signup and view all the answers
Which statements made by a male patient indicate an understanding of potential side effects of chemotherapeutic drugs?
Which statements made by a male patient indicate an understanding of potential side effects of chemotherapeutic drugs?
Signup and view all the answers
What is the treatment cycle frequency for fluorouracil when prescribed with other agents?
What is the treatment cycle frequency for fluorouracil when prescribed with other agents?
Signup and view all the answers
Study Notes
Pharmacology Key Concepts
- Cyclophosphamide is primarily excreted through the kidneys.
- Fluorouracil affects DNA during the S phase of the cell cycle.
- Liposomal chemotherapy involves drugs packaged in fat globules, enhancing delivery.
- Tamoxifen functions as both an agonist and antagonist at estrogen receptor sites.
Anti-Emetic Administration
- Administer anti-emetic therapy just before cyclophosphamide administration to maximize its benefit.
Chemotherapy Administration Protocol
- Chemotherapeutic drugs should be prepared in a separate work area to ensure safety.
- Vincristine liposomal is an expected treatment for patients with Philadelphia chromosome-negative acute lymphoblastic leukemia.
Drug Interactions and Effects
- CYP2D6 inducers, like phenobarbital, decrease the concentration of chemotherapeutic drugs, potentially reducing their efficacy.
- The S phase is where most antimetabolites exert their effects on cells.
Pharmacokinetics
- Cyclophosphamide peaks in the bloodstream approximately two hours after administration.
Combination Therapy Advantages
- Using multiple classes of chemotherapeutic drugs enhances therapeutic effects and reduces drug resistance, increasing cancer cell destruction.
Drug Administration Methods
- Vincristine must be administered intravenously due to low absorption rates with oral ingestion.
- In cases of plant allergies (e.g., periwinkle), notify the healthcare provider if prescribing vincristine.
Patient Education
- Doxorubicin, an antitumor antibiotic, does not prevent infections; patients should remain vigilant about infection risks.
- Use of face shields while disposing of patient urine mitigates occupational exposure risks.
Dosage Considerations
- Hold oral cyclophosphamide for patients weighing 125 pounds if prescribed at 700 mg (consider dosage adjustment).
- Anticipate administering colony-stimulating factors (CSFs) in response to significant neutrophil drop.
Management of Side Effects
- For patients with mouth lesions due to chemotherapy, topical anesthetics are the most likely intervention to facilitate eating and swallowing.
Patient Understanding of Side Effects
- Patients should be educated on managing mouth care with a soft toothbrush, and the potential need for stool softeners to alleviate constipation.
- Banking sperm is advisable for male patients to preserve fertility options post-chemotherapy.
Treatment Schedule
- Fluorouracil is typically repeated every two weeks as part of a combination chemotherapy regimen for metastatic pancreatic cancer.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
Test your knowledge of key concepts in pharmacology with these flashcards. Covering important drugs, mechanisms, and cellular impacts, this quiz is designed to help reinforce your learning. Perfect for students and professionals alike.
