Podcast
Questions and Answers
Which enzyme do entacapone and tolcapone inhibit to block the conversion of dopamine?
Which enzyme do entacapone and tolcapone inhibit to block the conversion of dopamine?
What is the main route of excretion for the metabolites of safinamide?
What is the main route of excretion for the metabolites of safinamide?
Which metabolite of entacapone is found in human plasma as an inactive form?
Which metabolite of entacapone is found in human plasma as an inactive form?
What are the most common adverse effects associated with safinamide?
What are the most common adverse effects associated with safinamide?
Signup and view all the answers
Individuals using which of the following medications should not use safinamide?
Individuals using which of the following medications should not use safinamide?
Signup and view all the answers
Which medication is significantly metabolized prior to excretion, with only 0.2% of the parent drug found unchanged in urine?
Which medication is significantly metabolized prior to excretion, with only 0.2% of the parent drug found unchanged in urine?
Signup and view all the answers
What is the main metabolic pathway for the parent drug of entacapone?
What is the main metabolic pathway for the parent drug of entacapone?
Signup and view all the answers
Which enzyme is a selective and reversible inhibitor in the context of Parkinson's disease treatment?
Which enzyme is a selective and reversible inhibitor in the context of Parkinson's disease treatment?
Signup and view all the answers
What percentage of the urinary metabolites do the resulting glucuronides from the parent drug and the alkene isomer represent?
What percentage of the urinary metabolites do the resulting glucuronides from the parent drug and the alkene isomer represent?
Signup and view all the answers
Which neurological condition is tolcapone indicated for as an adjunct therapy?
Which neurological condition is tolcapone indicated for as an adjunct therapy?
Signup and view all the answers
What effect does the nitro group have on the metabolism of the catechol of entacapone?
What effect does the nitro group have on the metabolism of the catechol of entacapone?
Signup and view all the answers
In the cocrystal structure of tolcapone, what interaction does the catechol of tolcapone form?
In the cocrystal structure of tolcapone, what interaction does the catechol of tolcapone form?
Signup and view all the answers
Which enzyme is inhibited by safinamide?
Which enzyme is inhibited by safinamide?
Signup and view all the answers
What is the primary route of elimination for the metabolites of entacapone?
What is the primary route of elimination for the metabolites of entacapone?
Signup and view all the answers
Which compound may form directly by autooxidation of the parent drug carbidopa?
Which compound may form directly by autooxidation of the parent drug carbidopa?
Signup and view all the answers
What is the main mechanism of action for tolcapone in the treatment of Parkinson's disease?
What is the main mechanism of action for tolcapone in the treatment of Parkinson's disease?
Signup and view all the answers
What are the most common adverse events in advanced Parkinson's disease patients treated with carbidopa?
What are the most common adverse events in advanced Parkinson's disease patients treated with carbidopa?
Signup and view all the answers
Iron salts can reduce the bioavailability of carbidopa by:
Iron salts can reduce the bioavailability of carbidopa by:
Signup and view all the answers
Why does transfer not occur likely in the case of tolcapone?
Why does transfer not occur likely in the case of tolcapone?
Signup and view all the answers
What is the primary metabolite of tolcapone?
What is the primary metabolite of tolcapone?
Signup and view all the answers
Which enzyme is responsible for mediating methylation to 3-Omethyl-tolcapone?
Which enzyme is responsible for mediating methylation to 3-Omethyl-tolcapone?
Signup and view all the answers
What percentage of tolcapone is found unchanged in urine?
What percentage of tolcapone is found unchanged in urine?
Signup and view all the answers
Which enzyme is not involved in the metabolism of tolcapone?
Which enzyme is not involved in the metabolism of tolcapone?
Signup and view all the answers
What is a minor metabolite formed from tolcapone?
What is a minor metabolite formed from tolcapone?
Signup and view all the answers
What are the most common adverse effects associated with tolcapone?
What are the most common adverse effects associated with tolcapone?
Signup and view all the answers
Which enzyme is primarily inhibited by tolcapone?
Which enzyme is primarily inhibited by tolcapone?
Signup and view all the answers
Which of the following is a dopamine receptor agonist used in the treatment of Parkinson's disease?
Which of the following is a dopamine receptor agonist used in the treatment of Parkinson's disease?
Signup and view all the answers
What is the mechanism of action of apomorphine in the treatment of Parkinson's disease?
What is the mechanism of action of apomorphine in the treatment of Parkinson's disease?
Signup and view all the answers
Which class of alkaloids is apomorphine related to?
Which class of alkaloids is apomorphine related to?
Signup and view all the answers
In the treatment of advanced Parkinson's disease, what is safinamide indicated for?
In the treatment of advanced Parkinson's disease, what is safinamide indicated for?
Signup and view all the answers
