Drugs For Diabetes

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Questions and Answers

What is the main treatment for individuals with type 1 diabetes?

  • Diet control
  • Regular exercise
  • Exogenous insulin (correct)
  • Oral medications

Which factor does NOT influence the development of type 2 diabetes?

  • Autoimmune processes (correct)
  • Obesity
  • Aging
  • Genetic factors

What does HbA1c measure in individuals with diabetes?

  • Glucose control over the previous 3 months (correct)
  • Insulin production
  • Daily glucose levels
  • Carb intake

What is the main difference between type 1 and type 2 diabetes in terms of treatment?

<p>Type 1 requires exogenous insulin, while type 2 may be controlled with diet and exercise (B)</p> Signup and view all the answers

What is the goal of insulin therapy in individuals with type 1 diabetes?

<p>To avoid wide fluctuations in glucose levels (A)</p> Signup and view all the answers

Which factor differentiates the metabolic alterations in type 1 and type 2 diabetes?

<p>Ketosis (D)</p> Signup and view all the answers

Which type of insulin preparations are classified as rapid-acting insulins?

<p>Insulin lispro, insulin aspart, and insulin glulisine (C)</p> Signup and view all the answers

What is a key advantage of rapid-acting insulins when compared to regular insulin?

<p>They peak faster after subcutaneous injection (C)</p> Signup and view all the answers

Why should patients with asthma, chronic obstructive pulmonary disease, and smokers avoid inhaled insulin formulations?

<p>Due to the potential for bronchospasm (B)</p> Signup and view all the answers

What is the classification of regular insulin?

<p>Short-acting insulin (C)</p> Signup and view all the answers

What results from the modification of the amino acid sequence of regular insulin?

<p>Rapid absorption and quicker onset (D)</p> Signup and view all the answers

When are peak levels of insulin lispro typically seen compared to regular insulin?

<p>After 30-90 minutes (D)</p> Signup and view all the answers

Which GLP-1 receptor agonist is dosed once daily?

<p>Lixisenatide (D)</p> Signup and view all the answers

In patients with severe renal impairment, which drug should be avoided?

<p>Exenatide (short-acting) (D)</p> Signup and view all the answers

What have GLP-1 receptor agonists been associated with that warrants avoiding them in patients with chronic pancreatitis?

<p>Pancreatitis (D)</p> Signup and view all the answers

Which group of patients are most likely to respond well to oral glucose-lowering agents?

<p>Patients who developed diabetes after age 40 and have had diabetes for less than 5 years (C)</p> Signup and view all the answers

What side effects are primarily associated with incretin mimetics?

<p>Nausea, vomiting, diarrhea, and constipation (C)</p> Signup and view all the answers

In rodents, longer-acting GLP-1 receptor agonists have been associated with which type of tumors?

<p>Thyroid C-cell tumors (C)</p> Signup and view all the answers

What is the main disadvantage of using premixed insulin combinations?

<p>Increases the risk of hypoglycemic episodes (D)</p> Signup and view all the answers

What is a characteristic of standard insulin therapy?

<p>Linked to a higher frequency of hypoglycemic episodes (D)</p> Signup and view all the answers

What is a benefit of intensive insulin regimens according to the text?

<p>Significant reduction in microvascular complications (D)</p> Signup and view all the answers

Which patients should intensive therapy not be recommended for?

<p>Patients with hypoglycemic unawareness (A)</p> Signup and view all the answers

What hormone is co-secreted with insulin from β cells following food intake?

<p>Amylin (A)</p> Signup and view all the answers

What is the target mean blood glucose level recommended by the ADA for most patients?

<p>154 mg/dl or less (A)</p> Signup and view all the answers

What is the primary mechanism of action of sulfonylureas in treating diabetes?

<p>Stimulating insulin release from the pancreas (B)</p> Signup and view all the answers

Which pharmacokinetic property is true for sulfonylureas?

<p>May accumulate in renal insufficiency (B)</p> Signup and view all the answers

What is an adverse effect commonly associated with sulfonylureas?

<p>Weight gain (B)</p> Signup and view all the answers

How do sulfonylureas affect ATP-sensitive K+ channels in the pancreas?

<p>Close the channels, inhibiting insulin release (A)</p> Signup and view all the answers

What is a precaution that should be taken when prescribing sulfonylureas to patients?

<p>Being cautious in renal insufficiency (D)</p> Signup and view all the answers

Which statement is true about glyburide in individuals with renal impairment?

<p>It may increase the risk of hypoglycemia significantly (C)</p> Signup and view all the answers

Which condition warrants discontinuing metformin therapy?

<p>Acute myocardial infarction (A)</p> Signup and view all the answers

What is a possible consequence of long-term metformin use?

<p>Vitamin B12 deficiency (C)</p> Signup and view all the answers

Why should metformin be used cautiously in patients older than 80 years?

<p>Risk of lactic acidosis (B)</p> Signup and view all the answers

Which class of drugs includes pioglitazone and rosiglitazone?

<p>Thiazolidinediones (D)</p> Signup and view all the answers

How do thiazolidinediones lower insulin resistance?

<p>By acting as PPARγ agonists (D)</p> Signup and view all the answers

Which disorder is a contraindication for metformin use?

<p>Renal dysfunction (D)</p> Signup and view all the answers

What should be monitored periodically during metformin therapy?

<p>Vitamin B12 levels (C)</p> Signup and view all the answers

In which patients should metformin be temporarily discontinued?

<p>Those undergoing procedures with IV contrast (C)</p> Signup and view all the answers

What is the main mechanism of action of thiazolidinediones for lowering insulin resistance?

<p>Acting as PPARγ agonists (D)</p> Signup and view all the answers

Why are thiazolidinediones like pioglitazone and rosiglitazone considered insulin sensitizers?

<p>They lower insulin resistance by acting on PPARγ (C)</p> Signup and view all the answers

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