Drug Distribution in the Body

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Questions and Answers

Which type of drugs tend to stay within the blood and the fluid that surrounds cells?

  • Highly fat-soluble drugs
  • Fat-soluble drugs
  • Water-soluble drugs (correct)
  • Protein-binding drugs

In which part of the body does iodine mainly concentrate?

  • Fatty tissues
  • Brain tissue
  • Muscle tissue
  • Thyroid gland (correct)

Which drug rapidly enters the brain due to its high fat solubility?

  • Atenolol
  • Clorazepate
  • Penicillin
  • Rifampin (correct)

Which type of drugs can cross cell membranes more quickly than water-soluble drugs?

<p>Highly fat-soluble drugs (A)</p> Signup and view all the answers

Which type of drugs bind tightly to proteins circulating in the blood and leave the bloodstream very slowly?

<p>Protein-binding drugs (B)</p> Signup and view all the answers

Which hormone is primarily responsible for maintaining metabolic homeostasis and increasing metabolic rate?

<p>Triiodothyronine (T3) (A)</p> Signup and view all the answers

What is the role of thyroid hormone in normal growth and development?

<p>Developing skeletal and nervous systems (B)</p> Signup and view all the answers

Which organ secretes the hormones thyroxine (T4), triiodothyronine (T3), and calcitonin?

<p>Thyroid gland (B)</p> Signup and view all the answers

What is the primary function of calcitonin?

<p>Regulating blood calcium levels (C)</p> Signup and view all the answers

Which hormone will be used to refer to both thyroxine (T4) and triiodothyronine (T3)?

<p>Thyroid hormone (A)</p> Signup and view all the answers

Which hormone is critically important for normal growth, development, and energy metabolism?

<p>Triiodothyronine (T3) (C)</p> Signup and view all the answers

What is the main function of thyroglobulin in the thyroid functional unit?

<p>To provide a substrate for iodination of tyrosine residues (A)</p> Signup and view all the answers

Which enzyme is involved in the oxidation of iodide in the thyroid functional unit?

<p>Thyroperoxidase (C)</p> Signup and view all the answers

What is the end result of the coupling of iodinated tyrosine in the thyroid functional unit?

<p>Formation of T3 or T4 (C)</p> Signup and view all the answers

How are T4 and T3 released and secreted into the plasma in the thyroid functional unit?

<p>As a result of fusion of endocytotic vesicles with lysosomes (D)</p> Signup and view all the answers

What is the main function of thyroid-stimulating hormone (TSH) in the regulation of thyroid function?

<p>To control blood flow through the gland (B)</p> Signup and view all the answers

What is the primary action of thyroid hormones in the body?

<p>To produce a general increase in the metabolism of carbohydrates, fats, and proteins (A)</p> Signup and view all the answers

In which part of the body do thyroid hormones play a crucial role?

<p>Central nervous system (CNS) (C)</p> Signup and view all the answers

What causes thyrotoxicosis?

<p><strong>Excessive activity of</strong> thyroid hormones T3 and T4 (D)</p> Signup and view all the answers

What is the main effect of somatostatin on TSH release?

<p>To reduce basal TSH release (C)</p> Signup and view all the answers

Which substance induces TSH release from the anterior pituitary?

<p>Thyrotrophin-releasing hormone (TRH) (C)</p> Signup and view all the answers

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