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Questions and Answers
During the distribution phase, up to what point does the fraction of drug in the tissue compartment increase?
During the distribution phase, up to what point does the fraction of drug in the tissue compartment increase?
When does distribution equilibrium occur during the distribution phase?
When does distribution equilibrium occur during the distribution phase?
How do drug concentrations in the central and tissue compartments decline during distribution equilibrium?
How do drug concentrations in the central and tissue compartments decline during distribution equilibrium?
Which model describes drug kinetics in the elimination phase?
Which model describes drug kinetics in the elimination phase?
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How is the drug concentration in the tissue compartment described during the elimination phase?
How is the drug concentration in the tissue compartment described during the elimination phase?
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What can cause variations in drug concentrations among different tissues?
What can cause variations in drug concentrations among different tissues?
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Study Notes
Distribution Phase
- During the distribution phase, the fraction of drug in the tissue compartment increases up to a maximum in a given tissue, which may be greater or less than the plasma drug concentration.
- At maximum tissue concentrations, the rate of drug entry into the tissue equals the rate of drug exit from the tissue.
- This marks the achievement of distribution equilibrium, where the fraction of drug in the tissue compartment is in equilibrium with the fraction of drug in the central compartment.
Distribution Equilibrium
- During distribution equilibrium, drug concentrations in both the central and tissue compartments decline in parallel and more slowly compared to the distribution phase.
- The drug concentrations in both compartments decline at a slower rate during this phase.
Elimination Phase
- In the elimination phase, drug kinetics appear to follow a one-compartment model.
- Drug elimination is a first-order process described by β.
- The drug concentration in the tissue compartment represents the average drug concentration in a group of tissues, rather than a real anatomic tissue drug concentration.
Tissue Drug Concentrations
- In reality, drug concentrations may vary among different tissues and possibly within an individual tissue due to differences in the partitioning of drug into the tissues.
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Description
Quiz about the distribution phase of a drug, including the increase of drug concentration in tissue compartments and the equilibrium with the central compartment.
