Pharmacology: Cholinergic Antagonists Atropine

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What is the primary mechanism of action of atropine?

Competitive nicotinic ganglion blocker

Antimuscarinic receptor antagonist (correct)

Depolarization of ganglia ANS and striated muscle

Inhibition of neuromuscular transmission

Which of the following is a therapeutic use of scopolamine?

Relief of uveitis

Treatment of Parkinson's disease

Antidote for organophosphate toxicity

MANAGEMENT OF MOTION SICKNESS (correct)

What is the primary difference between atropine and scopolamine?

Atropine is used as an antidote for organophosphate toxicity

Scopolamine is an agonist at muscarinic receptors

Scopolamine is used to treat uveitis

Scopolamine has a longer duration of action in the CNS (correct)

What is the primary mechanism of action of ipratropium?

Antimuscarinic receptor antagonist Signup and view all the answers

Benztropine is primarily used as an adjuvant treatment for which condition?

Parkinson's disease Signup and view all the answers

What is the primary effect of cholinergic antagonists on the urinary system?

Decreased urination Signup and view all the answers

What is the primary pharmacokinetic characteristic of atropine?

Readily absorbed and partially metabolized in the liver Signup and view all the answers

Which of the following is a side effect of cholinergic antagonists?

Dry mouth Signup and view all the answers

What is the primary therapeutic use of darifenacin?

Treatment of overactive bladder Signup and view all the answers

What is the primary mechanism of action of trimethaphan?

Competitive nicotinic ganglion blocker Signup and view all the answers

What is the primary mechanism of action of competitive nicotinic ganglion blockers like mecamylamine?

Competing with acetylcholine for nicotinic receptors Signup and view all the answers

What is the main difference between depolarizing and non-depolarizing neuromuscular blockers?

Depolarizing blockers cause prolonged stimulation and subsequent desensitization of the receptors, while non-depolarizing blockers compete with acetylcholine for receptors Signup and view all the answers

What is the primary therapeutic use of Curane?

Muscle relaxation during surgery Signup and view all the answers

What is the primary mechanism of action of benzodiazepines?

Enhancing the activity of gamma-aminobutyric acid (GABA) Signup and view all the answers

What is the primary use of rocuronium?

Facilitating tracheal intubation during anesthesia Signup and view all the answers

What is the primary effect of nicotine on dopamine levels?

Increase in dopamine, leading to pleasure and appetite suppression Signup and view all the answers

What is the primary effect of mecamylamine on blood pressure?

Increase in blood pressure, leading to hypertension Signup and view all the answers

Which cholinergic antagonist has a stronger central nervous system effect than atropine?

Scopolamine Signup and view all the answers

What is the primary therapeutic use of ipratropium and tiotropium?

Asthma and COPD Signup and view all the answers

Which of the following cholinergic antagonists is used to treat overactive bladder?

All of the above Signup and view all the answers

What is the primary mechanism of action of trimethaphan?

Competitive nicotinic ganglion blocker Signup and view all the answers

What is the primary effect of nicotine on the autonomic nervous system?

Depolarization of ganglia and striated muscle Signup and view all the answers

Which of the following is a common side effect of cholinergic antagonists?

Dry mouth Signup and view all the answers

What is the primary therapeutic use of tropicamide?

Cycloplegic refraction and uveitis Signup and view all the answers

What is the primary mechanism of action of benztropine?

Centrally acting antimuscarinic agent Signup and view all the answers

What is the primary effect of atropine on the eye?

All of the above Signup and view all the answers

What is the primary mechanism of action of mecamylamine in the treatment of hypertension?

Competitive inhibition of nicotinic receptors in the ganglion Signup and view all the answers

What is the primary effect of nicotine on glutamate levels?

Increased release of glutamate Signup and view all the answers

What is the primary mechanism of action of non-depolarizing neuromuscular blockers?

Competitive inhibition of acetylcholine receptors Signup and view all the answers

What is the primary therapeutic use of succinylcholine?

Rapid endotracheal intubation during induction of anesthesia Signup and view all the answers

What is the primary effect of benzodiazepines on GABA?

Enhancement of GABA's inhibitory effects Signup and view all the answers

What is the primary adverse effect of succinylcholine?

Hyperthermia Signup and view all the answers

What is the primary mechanism of action of succinylcholine?

Depolarization of the neuromuscular junction Signup and view all the answers

What is the primary effect of nicotine on norepinephrine levels?

Increased release of norepinephrine Signup and view all the answers

Pharmacology: Cholinergic Antagonists Atropine

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Questions and Answers

What is the primary mechanism of action of atropine?

Which of the following is a therapeutic use of scopolamine?

What is the primary difference between atropine and scopolamine?

What is the primary mechanism of action of ipratropium?

Benztropine is primarily used as an adjuvant treatment for which condition?

What is the primary effect of cholinergic antagonists on the urinary system?

What is the primary pharmacokinetic characteristic of atropine?

Which of the following is a side effect of cholinergic antagonists?

What is the primary therapeutic use of darifenacin?

What is the primary mechanism of action of trimethaphan?

What is the primary mechanism of action of competitive nicotinic ganglion blockers like mecamylamine?

What is the main difference between depolarizing and non-depolarizing neuromuscular blockers?

What is the primary therapeutic use of Curane?

What is the primary mechanism of action of benzodiazepines?

What is the primary use of rocuronium?

What is the primary effect of nicotine on dopamine levels?

What is the primary effect of mecamylamine on blood pressure?

Which cholinergic antagonist has a stronger central nervous system effect than atropine?

What is the primary therapeutic use of ipratropium and tiotropium?

Which of the following cholinergic antagonists is used to treat overactive bladder?

What is the primary mechanism of action of trimethaphan?

What is the primary effect of nicotine on the autonomic nervous system?

Which of the following is a common side effect of cholinergic antagonists?

What is the primary therapeutic use of tropicamide?

What is the primary mechanism of action of benztropine?

What is the primary effect of atropine on the eye?

What is the primary mechanism of action of mecamylamine in the treatment of hypertension?

What is the primary effect of nicotine on glutamate levels?

What is the primary mechanism of action of non-depolarizing neuromuscular blockers?

What is the primary therapeutic use of succinylcholine?

What is the primary effect of benzodiazepines on GABA?

What is the primary adverse effect of succinylcholine?

What is the primary mechanism of action of succinylcholine?

What is the primary effect of nicotine on norepinephrine levels?

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