Podcast
Questions and Answers
What is the action of carbapenems?
What is the action of carbapenems?
- Activate bacteria to multiply
- Enhance bacterial cell wall synthesis
- Impair protein synthesis
- Inhibit bacterial cell wall synthesis (correct)
What are carbapenems used for?
What are carbapenems used for?
To treat severe infections by multidrug resistant organisms.
What are common adverse effects of carbapenems?
What are common adverse effects of carbapenems?
Severe diarrhea, dizziness, confusion, seizures, and phlebitis.
How does Probenecid interact with carbapenems?
How does Probenecid interact with carbapenems?
What effect do carbapenem antibiotics have on valproic acid?
What effect do carbapenem antibiotics have on valproic acid?
What is the interaction between Ganciclovir and carbapenems?
What is the interaction between Ganciclovir and carbapenems?
What is the brand name of Doripenem?
What is the brand name of Doripenem?
What is the brand name of Etrapenem?
What is the brand name of Etrapenem?
What is the brand name of Imipenem-Cilastatin?
What is the brand name of Imipenem-Cilastatin?
What is the brand name of Meropenem?
What is the brand name of Meropenem?
What assessments should be conducted before initiating therapy with carbapenems?
What assessments should be conducted before initiating therapy with carbapenems?
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Study Notes
Actions
- Inhibit bacterial cell wall synthesis
- Potent broad-spectrum agents
- Resistant to beta-lactamase enzymes secreted by bacteria
Uses
- Indicated for severe infections caused by multidrug-resistant organisms
Common Adverse Effects
- Severe diarrhea
- Dizziness
- Confusion and seizures, including myoclonic activity, focal tremors, and confusional states
- Risk of phlebitis; monitor for thrombophlebitis
Drug Interactions: Probenicid
- Inhibits urinary excretion of carbapenems
- Concomitant administration is contraindicated
Drug Interactions: Valproic Acid
- Carbapenem antibiotics may lower valproic acid levels
- Risk of loss of seizure control due to reduced levels
Drug Interaction: Ganciclovir
- Concurrent use of imipenem-cilastin with ganciclovir increases seizure incidence
- Avoid concurrent administration if possible
Doripenem
- Brand name: Doribax
Etrapenem
- Brand name: Invanz
Imipenem-Cilastin
- Brand name: Primaxin
Meropenem
- Brand name: Merrem IV
Premedication Assessment
- Assess and document gastric symptoms prior to therapy initiation
- Check for allergies, specifically to penicillin and cephalosporins
- Inquire about history of seizures
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