26 Questions
What is the maximum dosage of aspirin prescribed in 24 hours?
3.6 gm
What is the effect of aspirin on uric acid in the blood?
Increase in concentration
What is the primary use of aspirin in patients who have suffered a stroke?
As an antiplatelet drug
What is the treatment for aspirin overdose?
Induce vomiting and administer activated charcoal
What is the effect of aspirin on kidney function?
Increase in edema formation
What is the dosage of aspirin for an adult?
325-500mg not more than 4 gm in 24 hours
What is a rare disorder associated with aspirin intake in children?
Reye's Syndrome
What is the effect of aspirin on carbohydrate metabolism?
Increase in glucose levels
What is a potential consequence of prescribing aspirin to a child with a viral infection?
Reye's syndrome
What is a critical phrase to include when prescribing medication for pain management in children?
As needed
Which treatment should be administered within 12 hours in case of aspirin overdosage?
N-acetylcysteine
What is a symptom of hepatic necrosis due to aspirin overdosage?
Liver damage
Aspirin binds firmly to plasma proteins, which may displace which type of drugs?
Other drugs from the binding site
A common adverse reaction to aspirin is allergenicity. What does this imply?
Allergic reactions
What is a key step in the initial treatment of aspirin overdosage?
Gastric lavage
Which of the following conditions is not directly associated with aspirin use?
Hypertension
Which of the following describes a drug with no intrinsic activity but has an affinity to block the effect of another drug?
Antagonist
What is the relationship between drug dosage and effect called when the effect does not increase regardless of further dosage increments?
Maximal Effect
What type of drug reaction cannot be attributed to a drug allergy and presents differently in a minority of patients?
Drug Idiosyncrasy
Which example represents an additive effect where the combined drug effect is an algebraic sum of their individual responses?
Ibuprofen and Paracetamol
Which term is used for a drug that increases the potency of another drug without having a significant effect on its own?
Potentiation
What type of adverse reaction is mediated by sensitized cells and can manifest after a day or more?
Delayed Drug Allergy
Which type of drug interaction refers to a greater than additive effect when combining two drugs?
Synergism
Which adverse reaction occurs immediately and is mediated by circulating antibodies?
Intermediate Drug Allergy
To manage excessive bleeding in a patient taking warfarin, it is crucial to avoid drugs that exhibit what type of interaction?
Pharmacologic Antagonism
Which term is defined as the amount of drug necessary to produce a maximal effect?
Potency
This quiz covers the mechanisms of drug action, including drugs that do not act via pharmacological receptors and the relationship between drug dose and effect.
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