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Questions and Answers
What is superinfection primarily caused by?
What is superinfection primarily caused by?
- Overuse of antibiotics
- A deficiency in the immune system
- An overgrowth of drug-resistant microorganisms (correct)
- The administration of a broad-spectrum drug
Which technique provides less effective results for bacteria that are anaerobic or highly fastidious?
Which technique provides less effective results for bacteria that are anaerobic or highly fastidious?
- Kirby-Bauer technique (correct)
- Minimum inhibitory concentration testing
- PCR amplification
- Tube dilution tests
Which of the following is NOT a reason for treatment failure during antimicrobial therapy?
Which of the following is NOT a reason for treatment failure during antimicrobial therapy?
- Inability of the drug to diffuse into body compartments
- Infection caused by multiple pathogens, some of which are resistant
- Single-pathogen infections that are sensitive to the drug (correct)
- Presence of antibiotic-resistant strains not detected in tests
What does the minimum inhibitory concentration (MIC) refer to?
What does the minimum inhibitory concentration (MIC) refer to?
When treatment fails, what is a possible alternative option?
When treatment fails, what is a possible alternative option?
Flashcards
Superinfection
Superinfection
An infection caused by a drug-resistant microorganism, occurring during antimicrobial therapy.
Kirby-Bauer technique
Kirby-Bauer technique
An agar diffusion test determining antibiotic susceptibility (effectiveness) of bacteria.
Tube dilution test
Tube dilution test
A test for antimicrobial susceptibility that measures the minimum concentration needed to inhibit bacterial growth.
Minimum Inhibitory Concentration (MIC)
Minimum Inhibitory Concentration (MIC)
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Why does antimicrobial treatment sometimes fail?
Why does antimicrobial treatment sometimes fail?
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Study Notes
Chapter 12 Notes
- Drug side effects fall into three categories: direct tissue damage, toxicity, allergic reactions, and disruption of the body's microbiome.
- Drug damage can be temporary or permanent.
- Superinfection occurs during antimicrobial therapy. It is caused by an overgrowth of drug-resistant microbes.
- The Kirby-Bauer technique is an agar diffusion test for antimicrobial susceptibility. It's less effective for anaerobic, fastidious, or slow-growing bacteria..
- Tube dilution tests are more sensitive and give quantitative results than the Kirby-Bauer test.
- The minimum inhibitory concentration (MIC) is the smallest drug concentration to visibly inhibit microbial growth.
- Antimicrobial treatment failure is often due to: drug inability to diffuse into body compartments, resistant cells, or mixed infections with resistant pathogens.
- If therapy fails, consider alternative drugs, combined therapies, or different administration methods.
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Description
Explore the intricacies of drug side effects and antimicrobial therapy in this quiz. Learn about different types of drug damage, mechanisms of superinfection, and testing techniques like the Kirby-Bauer method. Assess your understanding of key concepts such as minimum inhibitory concentration (MIC) and factors affecting treatment failure.
