Pharmacology Chapter 12
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Questions and Answers

What is superinfection primarily caused by?

  • Overuse of antibiotics
  • A deficiency in the immune system
  • An overgrowth of drug-resistant microorganisms (correct)
  • The administration of a broad-spectrum drug
  • Which technique provides less effective results for bacteria that are anaerobic or highly fastidious?

  • Kirby-Bauer technique (correct)
  • Minimum inhibitory concentration testing
  • PCR amplification
  • Tube dilution tests
  • Which of the following is NOT a reason for treatment failure during antimicrobial therapy?

  • Inability of the drug to diffuse into body compartments
  • Infection caused by multiple pathogens, some of which are resistant
  • Single-pathogen infections that are sensitive to the drug (correct)
  • Presence of antibiotic-resistant strains not detected in tests
  • What does the minimum inhibitory concentration (MIC) refer to?

    <p>The smallest concentration of a drug that visibly inhibits growth</p> Signup and view all the answers

    When treatment fails, what is a possible alternative option?

    <p>Using a different drug</p> Signup and view all the answers

    Study Notes

    Chapter 12 Notes

    • Drug side effects fall into three categories: direct tissue damage, toxicity, allergic reactions, and disruption of the body's microbiome.
    • Drug damage can be temporary or permanent.
    • Superinfection occurs during antimicrobial therapy. It is caused by an overgrowth of drug-resistant microbes.
    • The Kirby-Bauer technique is an agar diffusion test for antimicrobial susceptibility. It's less effective for anaerobic, fastidious, or slow-growing bacteria..
    • Tube dilution tests are more sensitive and give quantitative results than the Kirby-Bauer test.
    • The minimum inhibitory concentration (MIC) is the smallest drug concentration to visibly inhibit microbial growth.
    • Antimicrobial treatment failure is often due to: drug inability to diffuse into body compartments, resistant cells, or mixed infections with resistant pathogens.
    • If therapy fails, consider alternative drugs, combined therapies, or different administration methods.

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    Description

    Explore the intricacies of drug side effects and antimicrobial therapy in this quiz. Learn about different types of drug damage, mechanisms of superinfection, and testing techniques like the Kirby-Bauer method. Assess your understanding of key concepts such as minimum inhibitory concentration (MIC) and factors affecting treatment failure.

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