Pharmacology: Cardiac Glycoside Digoxin
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Questions and Answers

Digoxin is a type of ______ glycoside.

cardiac

The mechanism of action of Digoxin involves inhibiting the activity of the myocardial ______ ATPase enzyme.

Na+/K+

Digoxin increases the ______ fraction, which is the volume ejected with each contraction of the heart.

LV's ejection

Digoxin treats atrial fibrillation (AFib) by increasing the ______ node's effective refractory period.

<p>AV</p> Signup and view all the answers

Digoxin is a ______ that increases myocardial efficiency and improves its contractions, leading to improved blood flow.

<p>cardiotonic</p> Signup and view all the answers

Digoxin is a type of cardiac ______ that increases myocardial efficiency and improves its contractions, leading to improved blood flow.

<p>glycoside</p> Signup and view all the answers

Treats HF by increasing the ______ 's ejection fraction, which is the volume ejected with each contraction.

<p>LV's</p> Signup and view all the answers

Digoxin treats HF by increasing the force and velocity of ______ contractions, and decreasing the conduction rate.

<p>myocardial</p> Signup and view all the answers

Digoxin does this by inhibiting the activity of the ______ Na+/K+ ATPase enzyme, which controls the movement of ions into the heart.

<p>myocardial</p> Signup and view all the answers

Treats AFib by decreasing the ______ rate and increasing the AV node's effective refractory period.

<p>conduction</p> Signup and view all the answers

Study Notes

Digoxin

  • A cardiac glycoside, antiarrhythmic, and cardiotonic medication
  • Increases myocardial efficiency and improves contractions, resulting in enhanced blood flow

Mechanism of Action (MOA)

  • Inhibits myocardial Na+/K+ ATPase enzyme (sodium pump), controlling ion movement in the heart
  • Increases left ventricle's ejection fraction, strengthening heart contractions
  • Boosts the force and velocity of myocardial contractions
  • Decreases the conduction rate

Treatment of Atrial Fibrillation (AFib)

  • Decreases conduction rate
  • Increases the AV node's effective refractory period, preventing rapid cell responses to new stimuli

Digoxin

  • A cardiac glycoside, antiarrhythmic, and cardiotonic medication
  • Increases myocardial efficiency and improves contractions, resulting in enhanced blood flow

Mechanism of Action (MOA)

  • Inhibits myocardial Na+/K+ ATPase enzyme (sodium pump), controlling ion movement in the heart
  • Increases left ventricle's ejection fraction, strengthening heart contractions
  • Boosts the force and velocity of myocardial contractions
  • Decreases the conduction rate

Treatment of Atrial Fibrillation (AFib)

  • Decreases conduction rate
  • Increases the AV node's effective refractory period, preventing rapid cell responses to new stimuli

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Description

Learn about the mechanism of action of digoxin, a cardiac glycoside and antiarrhythmic, used to treat heart failure. Understand its effects on myocardial contractions and sodium pump inhibition.

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