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Pharmacology Bioavailability Quiz

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Questions and Answers

What is bioavailability in pharmacology?

The total amount of drug in the body after administration

The fraction of an administered drug that reaches the systemic circulation (correct)

The percentage of drug absorbed by the gastrointestinal tract

The rate at which a drug is metabolized in the body

Why is bioavailability 100% when a medication is administered intravenously?

It is less prone to drug-drug interactions

It undergoes slower distribution in the body

It bypasses intestinal absorption and first-pass metabolism (correct)

It has a higher molecular weight

How is bioavailability mathematically defined?

Difference between drug concentration in plasma and tissue

Ratio of AUC for extravascular formulation to AUC for intravascular formulation (correct)

Ratio of drug concentration at peak time to drug concentration at trough time

Percentage of drug excreted unchanged in urine

Why is AUC used to measure bioavailability?

AUC is proportional to the dose that has entered the systemic circulation Signup and view all the answers

Why is the deviation range shown as ± for the bioavailability of a drug?

To take population variability into account Signup and view all the answers

What is bioavailability in pharmacology?

Bioavailability in pharmacology refers to the fraction (%) of an administered drug that reaches the systemic circulation. Signup and view all the answers

Why is bioavailability lower when a medication is administered via routes other than intravenous?

Bioavailability is lower when a medication is administered via routes other than intravenous due to intestinal epithelium absorption and first-pass metabolism. Signup and view all the answers

What is the mathematical formula for calculating bioavailability?

Bioavailability equals the ratio of comparing the area under the plasma drug concentration curve versus time (AUC) for the extravascular formulation to the AUC for the intravascular formulation. Signup and view all the answers

Why is the AUC used to measure bioavailability?

AUC is used to measure bioavailability because it is proportional to the dose that has entered the systemic circulation. Signup and view all the answers

Why is the deviation range shown as ± for the bioavailability of a drug?

The deviation range is shown as ± for the bioavailability of a drug to take population variability into account and ensure appropriate dosing for individuals with poor absorption. Signup and view all the answers

Study Notes

Bioavailability in Pharmacology

Bioavailability refers to the fraction of an administered dose of a medication that reaches the systemic circulation, making it available for therapeutic action.

Factors Affecting Bioavailability

Bioavailability is 100% when a medication is administered intravenously, as the entire dose directly enters the bloodstream.
Bioavailability is lower when a medication is administered via routes other than intravenous, such as oral or topical, due to factors like absorption, metabolism, and first-pass effect.

Mathematical Definition of Bioavailability

Bioavailability is mathematically defined as the ratio of the area under the curve (AUC) of the drug concentration-time profile after non-intravenous administration to the AUC after intravenous administration.

Role of AUC in Measuring Bioavailability

AUC is used to measure bioavailability because it represents the total amount of drug absorbed into the bloodstream over time.

Representation of Bioavailability

The deviation range of bioavailability is shown as ± to indicate the variability in the measurement, which is important for understanding the reliability of the results.

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Description

Test your knowledge of pharmacology bioavailability with this quiz. Explore the factors influencing drug absorption and the concept of bioavailability when medication is administered intravenously or via other routes.