10 Questions
What is bioavailability in pharmacology?
The fraction of an administered drug that reaches the systemic circulation
Why is bioavailability 100% when a medication is administered intravenously?
It bypasses intestinal absorption and first-pass metabolism
How is bioavailability mathematically defined?
Ratio of AUC for extravascular formulation to AUC for intravascular formulation
Why is AUC used to measure bioavailability?
AUC is proportional to the dose that has entered the systemic circulation
Why is the deviation range shown as ± for the bioavailability of a drug?
To take population variability into account
What is bioavailability in pharmacology?
Bioavailability in pharmacology refers to the fraction (%) of an administered drug that reaches the systemic circulation.
Why is bioavailability lower when a medication is administered via routes other than intravenous?
Bioavailability is lower when a medication is administered via routes other than intravenous due to intestinal epithelium absorption and first-pass metabolism.
What is the mathematical formula for calculating bioavailability?
Bioavailability equals the ratio of comparing the area under the plasma drug concentration curve versus time (AUC) for the extravascular formulation to the AUC for the intravascular formulation.
Why is the AUC used to measure bioavailability?
AUC is used to measure bioavailability because it is proportional to the dose that has entered the systemic circulation.
Why is the deviation range shown as ± for the bioavailability of a drug?
The deviation range is shown as ± for the bioavailability of a drug to take population variability into account and ensure appropriate dosing for individuals with poor absorption.
Study Notes
Bioavailability in Pharmacology
- Bioavailability refers to the fraction of an administered dose of a medication that reaches the systemic circulation, making it available for therapeutic action.
Factors Affecting Bioavailability
- Bioavailability is 100% when a medication is administered intravenously, as the entire dose directly enters the bloodstream.
- Bioavailability is lower when a medication is administered via routes other than intravenous, such as oral or topical, due to factors like absorption, metabolism, and first-pass effect.
Mathematical Definition of Bioavailability
- Bioavailability is mathematically defined as the ratio of the area under the curve (AUC) of the drug concentration-time profile after non-intravenous administration to the AUC after intravenous administration.
Role of AUC in Measuring Bioavailability
- AUC is used to measure bioavailability because it represents the total amount of drug absorbed into the bloodstream over time.
Representation of Bioavailability
- The deviation range of bioavailability is shown as ± to indicate the variability in the measurement, which is important for understanding the reliability of the results.
Test your knowledge of pharmacology bioavailability with this quiz. Explore the factors influencing drug absorption and the concept of bioavailability when medication is administered intravenously or via other routes.
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