Pharmacology Basics Quiz

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Questions and Answers

What is John's Wort primarily indicated for?

  • Severe insomnia
  • Mild depression (correct)
  • Severe anxiety
  • Chronic pain relief

Which of the following is a common side effect of Valerian?

  • Increased appetite
  • Constipation
  • Dry mouth
  • Drowsiness (correct)

For which condition is John's Wort contraindicated?

  • Chronic fatigue
  • Cocaine use (correct)
  • Seasonal affective disorder
  • Mild headaches

What is the primary neurotransmitter affected by Valerian?

<p>GABA (D)</p> Signup and view all the answers

Which circumstance would contraindicate the use of Valerian?

<p>Breastfeeding (B)</p> Signup and view all the answers

What is the primary focus of pharmacology?

<p>The study of drugs and their interactions with living organisms (C)</p> Signup and view all the answers

Which of the following is NOT a characteristic of an ideal drug?

<p>Is expensive and hard to obtain (C)</p> Signup and view all the answers

What defines a placebo in a clinical setting?

<p>An inactive substance used as a control (A)</p> Signup and view all the answers

In pharmacotherapy, what does the term 'prototype' refer to?

<p>A standard example used for comparison within a drug class (A)</p> Signup and view all the answers

Which statement best describes pharmacotherapy?

<p>It involves the treatment of diseases using various therapeutic methods. (C)</p> Signup and view all the answers

What is a characteristic of a brand name drug?

<p>It can have multiple names. (A)</p> Signup and view all the answers

Which of the following is true about generic names of drugs?

<p>There is only one generic name per drug. (B)</p> Signup and view all the answers

What aspect defines a drug's pharmacologic class?

<p>The specific mechanism by which the drug acts. (B)</p> Signup and view all the answers

What is the purpose of Phase 1 in clinical trials?

<p>To determine safety aspects of the drug. (B)</p> Signup and view all the answers

Which of the following best describes the therapeutic class of a drug?

<p>It focuses on the specific health condition the drug treats. (B)</p> Signup and view all the answers

Which route of administration typically has the highest bioavailability?

<p>Parenteral (B)</p> Signup and view all the answers

What is a primary advantage of enteral administration?

<p>Aseptic technique not required (D)</p> Signup and view all the answers

Which of the following is a disadvantage of parenteral administration?

<p>Requires training to administer (D)</p> Signup and view all the answers

What is the purpose of a depot injection?

<p>To deliver a drug for prolonged release over time (D)</p> Signup and view all the answers

Which of the following describes a key disadvantage of topical administration?

<p>Limited drug options available (A)</p> Signup and view all the answers

When applying a transdermal patch, what is a crucial step to ensure proper adhesion?

<p>Press the patch firmly for 10 to 30 seconds (D)</p> Signup and view all the answers

What is a common drawback of enteral drug administration compared to parenteral methods?

<p>Relying on patient consciousness (B)</p> Signup and view all the answers

Which administration method can pose a risk of gastric irritation?

<p>Enteral (D)</p> Signup and view all the answers

What is the primary characteristic of Schedule 1 drugs?

<p>Illegal for non-research use under federal law (C)</p> Signup and view all the answers

Which of the following is a requirement for Schedule 2 prescriptions?

<p>Must be written and cannot be prescribed over the phone (D)</p> Signup and view all the answers

What distinguishes an Over-the-Counter (OTC) medication from a prescription drug?

<p>OTC medications may be harmful or ineffective (A)</p> Signup and view all the answers

Which drug schedule allows for a maximum of five refills or prescription rewriting after six months?

<p>Schedule 3 (B)</p> Signup and view all the answers

What is the main focus of pharmacokinetics in relation to medication?

<p>How medications travel through the body (D)</p> Signup and view all the answers

Which dosage form is known to have the highest bioavailability?

<p>Intravenous (IV) administration (B)</p> Signup and view all the answers

What does the term 'First Pass Effect' refer to?

<p>Metabolism of a drug by the liver before reaching general circulation (D)</p> Signup and view all the answers

What is a common misconception about prescription drugs?

<p>All prescription drugs are safe for everyone (A)</p> Signup and view all the answers

Which factor is NOT known to affect drug metabolism?

<p>Dietary habits (A)</p> Signup and view all the answers

What is the primary route that experiences first pass metabolism?

<p>Oral (B)</p> Signup and view all the answers

Which of the following statements about excretion is true?

<p>Reduced kidney function can slow elimination. (B)</p> Signup and view all the answers

An agonist is characterized by which of the following actions?

<p>It binds to a receptor to cause an effect. (C)</p> Signup and view all the answers

What does 'maintenance dose' refer to in pharmacology?

<p>A dose that keeps drug concentration within the therapeutic range. (B)</p> Signup and view all the answers

Which of the following describes 'trough level' in pharmacology?

<p>The lowest concentration of medication in an individual. (D)</p> Signup and view all the answers

Which factor can slow down drug excretion from the body?

<p>Aging (C), High urine pH (D)</p> Signup and view all the answers

Which definition correctly describes 'onset of action'?

<p>Time it takes after administration to reach minimum therapeutic effect. (D)</p> Signup and view all the answers

Flashcards

Pharmacology

The study of drugs, their properties, effects, and interactions with living organisms.

Pharmacotherapy

The use of drugs to treat diseases.

Drug

Any substance that alters physiological function.

Placebo

An inactive substance used as a control in experiments or therapy.

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Prototype

A typical example of a drug that serves as the standard for a class of drugs.

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Brand Name

The name given to a drug by the company that developed it. It's usually easy to remember and pronounce, and needs to be approved by the FDA. The first letter is capitalized.

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Generic Name

The scientific name of a drug, usually a longer and more complex term. It describes the chemical structure of the drug. The first letter is lowercase.

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Chemical Name

The exact chemical description of a drug, often very long and complicated. It tells you the exact chemical makeup of the drug.

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Therapeutic Class

How a drug works to treat a specific condition. It describes the intended effect of the drug.

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Pharmacologic Class

The way a drug acts on the body to produce its therapeutic effect. It describes the mechanism of action.

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Drug Schedules

Drugs categorized based on their potential for abuse and addiction, from Schedule 1 (highest abuse potential) to Schedule 4 (low abuse potential).

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Schedule 1 Drug

A drug that is illegal to possess or use without a prescription, and has a significant potential for abuse.

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Schedule 2 Drug

A drug that has accepted medical uses but high potential for abuse, requiring strict regulations and limited access.

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Schedule 3 Drug

A drug that has accepted medical uses but a moderate to low potential for abuse, allowing for more relaxed prescriptions.

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Schedule 4 Drug

A drug that has accepted medical uses but a low potential for abuse and dependence, allowing for relatively easy prescriptions.

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Prescription Drugs (Rx)

Medicines available only with a prescription from a healthcare professional, indicating a higher level of regulation due to potential risks or complexity.

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Over-the-Counter Drugs (OTC)

Medicines freely available for purchase without a prescription, generally aimed at addressing common health concerns.

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Pharmacokinetics

The process by which drugs are absorbed, distributed, metabolized, and excreted in the body, determining drug concentration in the bloodstream.

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First-pass metabolism

The process where a drug is metabolized by the liver before reaching systemic circulation, potentially reducing its bioavailability.

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Parenteral administration

A dosage form that delivers a drug directly into the bloodstream, bypassing the first-pass effect.

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Depot injection

A type of drug delivery method that uses a sustained-release formulation to provide a drug over an extended period.

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Topical administration

A drug delivery route that involves applying medication directly to the skin, eyes, ears, or vaginal area.

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Transdermal patch application

The intentional placement of a transdermal patch on a clean, dry, hairless area of skin.

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Enteral administration

A method for drug administration that uses the gastrointestinal tract. Examples include oral, sublingual, and rectal.

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Bioavailability

The availability of a drug to reach the systemic circulation after administration.

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Drug elimination

The process by which a drug is eliminated from the body, primarily through the liver and kidneys.

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What is St. John's Wort?

St. John's Wort is a natural herb used to treat mild depression and pain. It increases serotonin levels similarly to antidepressants, but with fewer side effects and a shorter duration of action.

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When is St. John's Wort contraindicated?

St. John's Wort is not recommended for individuals taking antidepressants, amphetamines, or cocaine, as it can cause undesirable interactions.

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What is Valerian used for?

Valerian is a natural herb often used to manage insomnia and anxiety. It acts by increasing GABA levels in the brain, promoting relaxation and sleep.

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What are some potential side effects and contraindications of Valerian?

Valerian is known to cause drowsiness and depressive effects. Due to its calming nature, it's contraindicated in individuals who are pregnant, breastfeeding, or taking CNS depressants like alcohol.

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How does Valerian work?

GABA is a neurotransmitter that plays a role in regulating brain function and relieving anxiety. By increasing GABA levels, valerian promotes a relaxed state and helps with sleep.

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Drug Metabolism

The chemical modification of drugs, primarily occurring in the liver. Think of it as the body breaking down the drug into smaller pieces.

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Drug Excretion

The removal of drugs and their byproducts from the body, mainly through urine. Think of it as the body getting rid of the drug.

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Agonist

A drug that binds to a receptor and causes a specific effect. Think of it as the 'key' fitting into the 'lock' and triggering an action.

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Partial Agonist

A drug that binds to a receptor but only causes a partial effect. Think of it as the 'key' fitting into the 'lock' but only partially turning it.

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Antagonist

A drug that binds to a receptor, blocking other drugs from activating it. Think of it as a 'key' fitting into the 'lock' but preventing anything from opening it.

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Loading Dose

A large initial dose of a drug given to quickly achieve therapeutic levels. Think of it as 'getting started' with a drug.

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Maintenance Dose

A lower dose of a drug given regularly to maintain therapeutic levels. Think of it as 'keeping the drug levels steady'.

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Study Notes

Introduction to Pharmacology

  • Pharmacology: The study of drugs, their properties, effects, and interactions with living organisms.
  • Pharmacotherapy: The treatment of diseases using drugs.
  • Drug: Any substance that alters physiological function.
  • Placebo: An inactive substance used as a control in experiments or therapies.
  • Prototype: A standard or typical example of a drug used to compare other drugs in the same class.
  • Ideal Drug: A medication that meets specific criteria for efficacy, safety, and convenience.

Characteristics of an Ideal Drug

  • Effectively treats, prevents, or cures a condition.
  • Rapid and predictable response at low doses.
  • Quickly eliminated by the body after the therapeutic effect is produced.
  • Can be taken infrequently or for a short time.
  • Affordable and readily available.
  • Convenient administration.
  • No adverse effects.
  • Does not interact with other medications or food.

Drug Naming

  • Trade Name (Brand Name): Created by the drug company, often easier to remember and pronounce; must be approved by the FDA.
  • Generic Name: A single name for a drug; first letter is lowercase; examples: sildenafil, acetaminophen, ibuprofen, atorvastatin

Drug Schedules

  • Schedule 1: All non-research use is illegal; highest potential for abuse (Heroin, LSD, MDMA).
  • Schedule 2: Accepted medical use but high potential for abuse (Oxycodone, Morphine).
  • Prescription Drugs (Rx): Available only with a prescription; typically require training/skill to administer.
  • Over-the-Counter Drugs (OTC): Available to the general population without a prescription.

Drug Development and Approval

  • Laboratory Research, Pre-clinical Research, Clinical Trials (Phase 1 – Safety, Phase 2 – Effectiveness, Phase 3 – Patient Variability & Drug Interactions), Government Review, Post-Marketing Surveillance.

Pharmacokinetics

  • Bioavailability: The amount of a drug that reaches the bloodstream after administration.
  • First-Pass Metabolism: When a drug is absorbed through the intestines, it passes through the liver before entering general circulation. Some of the drug may be broken down, reducing bioavailability.

Routes of Administration

  • Enteral: Oral (tablet, capsule, controlled release), sublingual, buccal, nasogastric tube, rectal.
  • Parenteral: Intravenous, intramuscular, subcutaneous, intradermal, epidural, transdermal.
  • Topical: Transdermal, eye, ear, vaginal.
  • Inhalation: Vaporization, gas inhalation, nebulization.

Factors Affecting Absorption

  • Administration route
  • Drug solubility
  • pH levels
  • Presence of food

Drug Toxicity

  • Teratogenicity: Causes harm to a developing fetus.
  • Nephrotoxicity: Damage to the kidneys.
  • Hepatotoxicity: Damage to the liver.
  • Neurotoxicity: Damage to the brain or nerves.
  • Dermatologic toxicity: Damage to the skin.
  • Ototoxicity: Damage to the ear.
  • Musculoskeletal toxicity: Damage to muscles or tendons.
  • Bone marrow suppression: Impaired production of blood cells.
  • Cardiotoxicity: Damage to the heart

Drug Interactions

  • Drugs interacting with other drugs, foods, or other substances.

Medication Errors

  • Strategies to reduce medication errors involve up-to-date knowledge, sticking to what's known, scanning and confirming information, consulting interdisciplinary teams, writing out orders, not having look-a-likes and sound-a-likes stored together.

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