Pharmacology Basics: Drug Absorption and Action

The ability of some tissues to attract, accumulate and store drugs in high concentrations relative to other tissues.

Blood vessels that selectively let certain substances enter the brain tissue and keep other substances out.

<p>The process by which molecules tend to move from an area of higher concentration to an area of lower concentration.</p> Signup and view all the answers

<p>The transport of drugs throughout the body after they are absorbed.</p> Signup and view all the answers

<p>Formed when a drug binds reversibly to a plasma protein, making the drug unavailable for distribution.</p> Signup and view all the answers

<p>Recycling of drugs and other substances by the circulation of bile through the intestine and liver.</p> Signup and view all the answers

<p>The process by which a drug increases the activity of the hepatic microsomal enzymes.</p> Signup and view all the answers

<p>The process of removing substances from the body.</p> Signup and view all the answers

<p>The mechanism whereby drugs are absorbed into the hepatic portal circulation and are inactivated by the liver.</p> Signup and view all the answers

<p>Inhibits many chemicals and drugs from entering the fetus.</p> Signup and view all the answers

<p>Liver enzymes that metabolize drugs as well as nutrients, also called the P-450 system.</p> Signup and view all the answers

<p>Multiple similar forms of an enzyme that perform slightly different metabolic functions.</p> Signup and view all the answers

<p>A relatively large dose of a drug given at the beginning of treatment to rapidly obtain a therapeutic response.</p> Signup and view all the answers

<p>The amount of drug that keeps the plasma drug concentration in the therapeutic range.</p> Signup and view all the answers

<p>The process used by the body to chemically change a drug molecule.</p> Signup and view all the answers

<p>The amount of drug required to produce a therapeutic effect.</p> Signup and view all the answers

<p>The study of drug movement throughout the body.</p> Signup and view all the answers

<p>The length of time required for the plasma concentration of a drug to decrease by one half after administration.</p> Signup and view all the answers

<p>Drugs that become more active after they are metabolized.</p> Signup and view all the answers

<p>A drug that is metabolized by a CYP enzyme.</p> Signup and view all the answers

<p>The practice of monitoring plasma levels of drugs with low safety profiles.</p> Signup and view all the answers

<p>The dosage that produces the desired effects of a drug.</p> Signup and view all the answers

<p>The level of a drug that results in serious adverse effects.</p> Signup and view all the answers

<p>A drug that activates a receptor and produces the same type of response as the endogenous substance.</p> Signup and view all the answers

<p>An agent that blocks the response of another drug.</p> Signup and view all the answers

<p>The way a patient responds to varying doses of a drug.</p> Signup and view all the answers

<p>The maximal response that can be produced from a particular drug.</p> Signup and view all the answers

<p>A graphic representation of the actual number of patients responding to a particular drug action at different doses.</p> Signup and view all the answers

<p>An unpredictable and unexplained drug reaction.</p> Signup and view all the answers

<p>The ability of a drug to bind to a receptor and produce a strong action.</p> Signup and view all the answers

<p>The amount of drug that is lethal to 1% of animals divided by the amount that produces a therapeutic effect in 99% of animals.</p> Signup and view all the answers

<p>The dose of a drug required to produce a specific therapeutic response in 50% of a group of patients.</p> Signup and view all the answers