Pharmacology and Liver Diseases

What is the key factor that determines the severity and site of action of a drug?

Concentration of the drug in the plasma

How does the effect of a liposoluble drug differ between obese and thin people when the drug is discontinued?

The effect lasts longer in obese people and disappears quickly in thin people.

How does drug elimination differ between newborns, infants, and children?

Newborns have the highest rate of drug elimination, while infants and children have lower rates.

How should the dose of a drug be adjusted for patients with different body weights?

Adjust the dose based on the patient's body surface area. Signup and view all the answers

How does the rate of drug elimination differ between men and women?

The rate of drug elimination depends on the specific drug and its metabolism, not on gender. Signup and view all the answers

How does drug distribution differ between newborns, infants, and children?

Newborns have the highest total body fluid and extracellular fluid volumes, while infants and children have lower volumes. Signup and view all the answers

What is the primary reason for the adjustment of plasma protein and plasma-fetus protein binding in pregnant women?

Increased albumin levels Signup and view all the answers

What is the primary mechanism by which antihypertensive drugs can reduce their own effectiveness over time?

Increased water and salt retention Signup and view all the answers

What is the primary reason for the difference in drug response between individuals?

Biological variability Signup and view all the answers

What is the primary difference between R (right) and S (left) isomers of a drug?

Both a and b Signup and view all the answers

What is the key characteristic of tolerance that distinguishes it from tachyphylaxis and desensitization?

All of the above Signup and view all the answers

What is the primary mechanism behind cross-tolerance between drugs in the same pharmacological group?

Shared pharmacodynamic properties Signup and view all the answers

Which of the following is the most likely reason for the increased severity of drug effects in obese individuals compared to thin individuals when the drug is discontinued?

Decreased drug elimination in obese individuals Signup and view all the answers

How does drug elimination differ between newborns, infants, and children?

The text does not provide information about differences in drug elimination between these age groups Signup and view all the answers

How does the effect of a liposoluble drug differ between obese and thin people when the drug is discontinued?

The text does not provide information about this Signup and view all the answers

What is the key factor that determines the severity and site of action of a drug?

The text does not provide information about this Signup and view all the answers

Pharmacology and Liver Diseases

Questions and Answers

What is the key factor that determines the severity and site of action of a drug?

How does the effect of a liposoluble drug differ between obese and thin people when the drug is discontinued?

How does drug elimination differ between newborns, infants, and children?

How should the dose of a drug be adjusted for patients with different body weights?

How does the rate of drug elimination differ between men and women?

How does drug distribution differ between newborns, infants, and children?

What is the primary reason for the adjustment of plasma protein and plasma-fetus protein binding in pregnant women?

What is the primary mechanism by which antihypertensive drugs can reduce their own effectiveness over time?

What is the primary reason for the difference in drug response between individuals?

What is the primary difference between R (right) and S (left) isomers of a drug?

What is the key characteristic of tolerance that distinguishes it from tachyphylaxis and desensitization?

What is the primary mechanism behind cross-tolerance between drugs in the same pharmacological group?

Which of the following is the most likely reason for the increased severity of drug effects in obese individuals compared to thin individuals when the drug is discontinued?

How does drug elimination differ between newborns, infants, and children?

How does the effect of a liposoluble drug differ between obese and thin people when the drug is discontinued?

What is the key factor that determines the severity and site of action of a drug?

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