Pharmacology and Drug Development Overview
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Questions and Answers

Which of the following is an example of a schedule 2 drug commonly found in dental hygiene practice?

  • Ibuprofen
  • Fluoride
  • Aspirin
  • Nitroglycerin (correct)
  • What is a characteristic of schedule 3 drugs?

  • They can be freely sold in any retail outlet.
  • They cannot be purchased without a prescription.
  • They pose no risks for any group of people.
  • They can be sold where a qualified health care professional is present. (correct)
  • Which of the following drugs is classified as unscheduled?

  • Fluoride rinse containing 1 mg or less of fluoride ion (correct)
  • Schedule II drugs
  • PreviDent® 5000
  • Nitroglycerin
  • What documentation is required for schedule II drugs in the US?

    <p>DEA registration and a written prescription.</p> Signup and view all the answers

    What must a dental hygienist demonstrate before being able to prescribe medications?

    <p>Successful completion of the DDHPE.</p> Signup and view all the answers

    Which of the following statements about the prescribing of drugs is accurate?

    <p>Prescribing principles must be followed for issuing prescriptions.</p> Signup and view all the answers

    How long does a written prescription for a schedule II drug remain valid after being phoned in?

    <p>72 hours</p> Signup and view all the answers

    Why are unscheduled drugs sold without professional intervention?

    <p>Their labeling is considered adequate for safe use.</p> Signup and view all the answers

    What significant discovery did human ancestors make regarding certain plants?

    <p>They could alter body functions and awareness.</p> Signup and view all the answers

    Which agency is primarily responsible for regulating drugs in healthcare?

    <p>Food and Drug Administration</p> Signup and view all the answers

    What was the 'tree of life' that Jacques Cartier referred to during his expedition?

    <p>A coniferous tree used as medicine.</p> Signup and view all the answers

    Which plant species did Indigenous peoples use to remove warts?

    <p>Taraxacum officinale</p> Signup and view all the answers

    What was a consequence of European contact on Indigenous populations in Canada?

    <p>Spread of new diseases among Indigenous peoples.</p> Signup and view all the answers

    Which factor significantly contributed to the development of new medicines after European contact?

    <p>Existing medicines applied to new ailments.</p> Signup and view all the answers

    What aspect of pharmacology is emphasized for providing safe client care in a clinical setting?

    <p>Understanding the history of drugs.</p> Signup and view all the answers

    What approach did newcomers to Canada take regarding Indigenous medicinal practices?

    <p>They adopted and learned about Indigenous plant medicines.</p> Signup and view all the answers

    What is primarily assessed during the preclinical stage of drug testing?

    <p>Carcinogenicity and teratogenicity</p> Signup and view all the answers

    What must occur before a drug can proceed to clinical trials?

    <p>Investigational New Drug (IND) approval</p> Signup and view all the answers

    Which phase of clinical trials focuses on safety and optimal dosage in a small group of subjects?

    <p>Phase 1</p> Signup and view all the answers

    In which stage can a drug be removed from the market due to serious toxicity issues?

    <p>Postmarketing Surveillance</p> Signup and view all the answers

    Which component of a prescription includes the directions for the pharmacist?

    <p>Subscription</p> Signup and view all the answers

    What information is included in the heading of a modern prescription?

    <p>Prescriber's and client's contact details</p> Signup and view all the answers

    Which of the following is NOT a responsibility of a licensed dental hygienist in prescription writing?

    <p>Writing prescriptions independently for all medications</p> Signup and view all the answers

    What should be charted by a dental hygienist when discussing prescriptions with a client?

    <p>Everything discussed regarding the prescription</p> Signup and view all the answers

    What is the primary requirement before issuing a prescription?

    <p>The patient must be a client of record.</p> Signup and view all the answers

    Which of the following is an essential component of a written prescription?

    <p>The date the drug is prescribed.</p> Signup and view all the answers

    When should verbal prescriptions be utilized?

    <p>Only in urgent situations.</p> Signup and view all the answers

    What is a limitation regarding faxing prescriptions?

    <p>Transmissions may contain errors that lead to misinterpretations.</p> Signup and view all the answers

    Which medication class is explicitly mentioned as being prescribed?

    <p>Chlorhexidine and its salts.</p> Signup and view all the answers

    Why does fluoride not require a prescription?

    <p>It contains less than 1 mg of fluoride ion per dosage unit.</p> Signup and view all the answers

    What should be reviewed before prescribing medication?

    <p>The patient's health history and current medications.</p> Signup and view all the answers

    Which type of information must not be included in a prescription?

    <p>Patient's insurance details.</p> Signup and view all the answers

    What is the main purpose of prescribing antibiotics in this case?

    <p>To completely treat the infection and prevent bacterial resistance</p> Signup and view all the answers

    What could be a reason for the client's gastrointestinal upset while taking the antibiotic?

    <p>The client did not take the medication with food</p> Signup and view all the answers

    How long should the client take the prescribed antibiotic for effective treatment?

    <p>For the entire duration prescribed, which is 10 days</p> Signup and view all the answers

    What aspect of the client's recent treatment does her statement about stopping the medication indicate?

    <p>She was unaware of the importance of completing the medication</p> Signup and view all the answers

    What should have been communicated to the client regarding the chlorhexidine mouth rinse?

    <p>It may cause alterations in taste and gastrointestinal upset</p> Signup and view all the answers

    What might be a consequence of the client not completing the antibiotic treatment?

    <p>Higher risk of developing bacterial resistance</p> Signup and view all the answers

    What indicates that the client was willing to comply with the mouth rinse treatment?

    <p>She reported using the mouth rinse every day</p> Signup and view all the answers

    Which of the following medications was prescribed to manage the client's pain?

    <p>Ibuprofen</p> Signup and view all the answers

    Study Notes

    History of Pharmacology

    • Pharmacology began when human ancestors discovered that consuming specific plants altered body functions and awareness.
    • Indigenous peoples have used medicinal plants for centuries; they have identified over 400 different species of plants, lichens, fungi, and algae with medicinal properties.
    • Europeans adopted many Indigenous plant medicines, like the "tree of life" used to cure scurvy by Jacques Cartier's crew.
    • Indigenous peoples also learned to use medicines from Europe and other parts of the world.

    Drug Development Phases

    • Preclinical Stage: Testing on animals lasting three years to assess carcinogenicity, teratogenicity, and drug breakdown and elimination.
    • Clinical Stage: Human trials requiring Investigational New Drug (IND) approval.
      • Phase 1: Small, increasing doses on limited subjects, testing safety, drug toxic effects, and dose range.
      • Phase 2: Larger number of subjects, testing dose range and effectiveness, adverse reactions reported to the FDA.
      • Phase 3: Large number of subjects, testing safety, dose, and efficacy.
    • NDA Review: New Drug Application (NDA) approval required before proceeding to postmarketing surveillance.
    • Postmarketing Surveillance (Phase 4): Drug released and marketed under supervision. Toxicity is monitored, and the drug may be removed from the market if serious issues arise.

    Drug Naming

    • Chemical Name: Describes the drug's chemical composition.
    • Generic Name: Non-proprietary name assigned by the manufacturer.
    • Trade Name: Brand name given by the manufacturer, marketed under this name.
    • Brand Name: Commercial name used for marketing.

    Drug Regulations

    • Canadian Classification of Drugs and Drug Scheduling: Drugs classified into unscheduled, Schedule 1, Schedule 2, or Schedule 3.
      • Unscheduled Drugs: Sold without professional intervention; considered safe and effective for self-selection, like acetaminophen, ibuprofen, and aspirin.
      • Schedule 3 Drugs: Can be bought without a prescription but sold only in pharmacies, like fluorides for caries prevention.
    • US Scheduled Drugs: Controlled substances divided into five schedules based on abuse potential.

    Role of Registered Dental Hygienist (RDH) in Prescription Writing

    • Responsibilities:
      • Checking for errors.
      • Answering client questions.
      • Giving client instructions, including dosage, duration, frequency, reason, side effects, and interactions, with repetition for confirmation.
      • Charting all information.
      • Monitoring for drug shoppers.
      • Safeguarding prescription pads and drugs.

    Modern Format for Prescriptions

    • Heading: Contains the prescribing professional's details (name, address, phone number), the client's details (name, address, phone number, age), and the date.
    • Body: Contains the Rx symbol, drug name and dosage, amount to be dispensed, directions to the client, and an example.
    • Closing: Includes the prescriber's signature, drug enforcement number, and refill instructions.

    Case Study: Periodontitis Treatment and Client Adherence

    • A 36-year-old female with a periodontal abscess received treatment, including ibuprofen, penicillin, and chlorhexidine rinse prescription.
    • Client's adherence was poor; she stopped taking the antibiotic and mouthwash due to side effects and not fully understanding the importance of completing the full course of treatment.
    • Case highlights the need for thorough patient education on proper medication use, side effects, and the importance of adherence, especially with antibiotics.

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    Description

    Explore the rich history of pharmacology, from ancient medicinal plant use to modern drug development. This quiz covers the essential stages in drug creation, including preclinical and clinical trials, and the significant contributions of indigenous knowledge. Test your understanding of how these elements shape contemporary pharmacological practices.

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