Pharmacology and Clinical Conditions Quiz
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Questions and Answers

Which of the following drugs can potentially influence the results of the erythrocyte sedimentation rate test?

  • Amoxicillin
  • Vitamin A (correct)
  • Ibuprofen
  • Penicillamine (correct)

What condition is most likely to cause an increased erythrocyte sedimentation rate due to elevated plasma proteins?

  • Hepatitis (correct)
  • Diabetes mellitus
  • Congestive heart failure
  • Acute heavy metal poisoning

Which factor can lead to a falsely decreased erythrocyte sedimentation rate reading?

  • Vibration
  • Low room temperature (correct)
  • High room temperature
  • Delay in testing

What effect does tilting ESR tubes have on the sedimentation rate results?

<p>It can cause an error up to 30°. (C)</p> Signup and view all the answers

Which of the following clinical conditions is NOT associated with an increased erythrocyte sedimentation rate?

<p>Cortisone treatment (C)</p> Signup and view all the answers

What is the consequence of having bubbles in the ESR column during testing?

<p>It causes a falsely low ESR reading. (A)</p> Signup and view all the answers

Which scenario would not lead to inaccurate erythrocyte sedimentation rate results?

<p>Conditioning samples at body temperature. (D)</p> Signup and view all the answers

In the context of ESR testing, what is a common complication when using a narrow ESR column diameter?

<p>Increased chance of error. (A)</p> Signup and view all the answers

Flashcards

ESR Technique Errors

Factors that can affect the accuracy of erythrocyte sedimentation rate (ESR) measurements.

Refrigerated Samples (ESR)

ESR samples not returned to room temperature before testing.

Incorrect Temperature (ESR)

High or low room temperature affecting ESR results.

Vibration (ESR)

Vibration during ESR testing can affect the sedimentation process.

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Tilted ESR Tubes

Tilting ESR tubes can cause inaccurate estimations of sedimentation rates.

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Clotted Blood Sample (ESR)

A blood sample that has clotted before ESR measurement will give inaccurate results.

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Delay in ESR Testing

Delayed ESR testing can lead to inaccurate results.

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Bubbles in ESR Column

Bubbles in the ESR column interfere with accurate measurement of sedimentation.

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Narrow ESR Tube Diameter

A narrow ESR tube diameter can affect sedimentation rate measurements.

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Drugs Affecting ESR

Certain medications or drugs can alter the ESR readings when present in the blood samples.

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Clinical Conditions Affecting ESR

Various medical conditions can influence erythrocyte sedimentation rates.

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Falsely Decreased ESR

ESR result appears lower than the actual value.

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Falsely Increased ESR

ESR result appears higher than the actual value.

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Study Notes

Drugs

  • Dextran
  • Heparin
  • Penicillamine
  • Procainamide
  • Theophylline
  • Vitamin A

Clinical Conditions

  • Inflammatory conditions (increased plasma proteins, particularly fibrinogen, alpha and beta globulins)
  • Infections (acute and chronic)
  • Subacute bacterial endocarditis
  • Acute heavy metal poisoning
  • Collagen vascular diseases
  • Diabetes mellitus
  • End-stage renal failure
  • Hepatitis
  • Gout
  • Malignancy
  • Menstruation
  • Multiple Myeloma (Plasma Cell Myeloma)
  • Waldenstrom's macroglobulinemia
  • Myocardial infarction
  • Rheumatic fever
  • Rheumatoid arthritis
  • Syphilis
  • Temporal arteritis
  • Nephrosis
  • Tuberculosis
  • Adrenocorticotropic hormone (corticotropin)
  • Cortisone
  • Ethambutol
  • Quinine
  • Salicylates
  • Cachexia
  • Congestive heart failure
  • Newborn status
  • Adults over 60 (slightly higher ESR due to decreased plasma albumin)
  • Pregnancy

Technique

  • A tilt of as little as 3° from vertical can cause error up to 30%
  • Refrigerated sample NOT returned to room temperature
  • High room temperature
  • Vibration
  • Tilted ESR tube
  • Clotted blood sample
  • Delay in testing
  • Bubbles in ESR column
  • Low room temperature
  • Narrow ESR column diameter

Sample Question 1

  • Placed sedimentation rate tubes directly on a small refrigerator due to lack of space.
  • Three possible effects on ESR results:
    • Falsely decreased ESR (↓) due to lower temperatures
    • Falsely increased ESR (↑) due to vibrations
    • Falsely increased ESR (↑) due to released heat

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Description

Test your knowledge on various drugs and their related clinical conditions. This quiz covers key medications and the medical scenarios in which they are used. Assess your understanding of treatments for inflammatory conditions, infections, and more.

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