Podcast
Questions and Answers
Which drug is an example of a non-selective COX inhibitor?
Which drug is an example of a non-selective COX inhibitor?
- Paracetamol
- Bethanechol
- Ibuprofen (correct)
- Pilocarpine
What is the function of mydriasis?
What is the function of mydriasis?
- Stimulation of salivary glands
- Constriction of pupils
- Dilation of pupils (correct)
- Regulation of heart rate
Which type of receptors do parasympathetic nerves have?
Which type of receptors do parasympathetic nerves have?
- Adrenergic receptors
- Muscarinic receptors (correct)
- Dopaminergic receptors
- Nicotinic receptors
What is the primary function of Nm receptors?
What is the primary function of Nm receptors?
Which type of receptors are G protein-coupled receptors?
Which type of receptors are G protein-coupled receptors?
Which drug is an example of a non-selective COX inhibitor?
Which drug is an example of a non-selective COX inhibitor?
What is the primary function of Nm receptors?
What is the primary function of Nm receptors?
What is the function of mydriasis?
What is the function of mydriasis?
Which type of receptors do parasympathetic nerves have?
Which type of receptors do parasympathetic nerves have?
Which type of receptors are G protein-coupled receptors?
Which type of receptors are G protein-coupled receptors?
Flashcards
Non-selective COX inhibitor example
Non-selective COX inhibitor example
Ibuprofen is a drug that inhibits both COX-1 and COX-2 enzymes.
Mydriasis function
Mydriasis function
Widening of the pupils of the eyes.
Parasympathetic receptors
Parasympathetic receptors
Muscarinic receptors are the receptors that parasympathetic nerves use.
Nm receptors function
Nm receptors function
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G protein-coupled receptor example
G protein-coupled receptor example
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Function of Nm receptors
Function of Nm receptors
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$eta$-adrenergic receptors
$eta$-adrenergic receptors
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Muscarinic receptors
Muscarinic receptors
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Skeletal muscle contraction
Skeletal muscle contraction
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Pupil dilation
Pupil dilation
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Study Notes
Opioid Analgesics
- Classified as narcotics or morphine-like analgesics
Non-Opioid Analgesics
- Classified as NSAIDs (Non-steroidal Anti-inflammatory Drugs) or non-narcotic/aspirin-like analgesics
- NSAIDs inhibit COX (Cyclooxygenase) enzymes, which convert arachidonic acid into prostaglandins
- Non-selective NSAIDs inhibit both COX-1 and COX-2, leading to decreased prostaglandin production
- Selective COX-2 inhibitors, such as meloxicam and celecoxib, only inhibit prostaglandin production
NSAIDs and Ulcers
- NSAIDs can cause ulcers due to decreased prostaglandin PGE2, which regulates mucus secretions
Paracetamol
- Analgesic but poor anti-inflammatory
- Belongs to the P-aminophenol derivatives class
Diclofenac
- Associated with liver dysfunction and failure
Renal Failure
- NSAIDs can cause renal failure due to dilation of GFR (Glomerular Filtration Rate)
Aspirin
- Causes Reye's syndrome
- Toxicity treated with sodium bicarbonate or dialysis in extreme cases
- Low dose inhibits TXA2 (Thromboxane A2)
- Irreversible inhibition of COX, unlike ibuprofen
COX-2 Inhibitors
- Cause platelet aggregation
Safest NSAID
- Naproxen has the safest cardiovascular risk profile
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Description
Test your knowledge of opioid and non-opioid analgesics, including their mechanisms of action and side effects. This quiz covers the effects of COX inhibitors, the differences between opioid and non-opioid analgesics, and the properties of specific drugs like paracetamol.
