Erythromycin's Effect on Diabetic Gastroparesis

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What is the bioavailability of Chloramphenicol?

80%

20%

50%

Nearly 100% (correct)

What is the elimination half-life of Chloramphenicol?

2 hours

1 hour

3 hours (correct)

4 hours

Where does Chloramphenicol cross the blood-brain barrier most effectively?

3 times more than plasma to brain tissue

9 times more than plasma to brain tissue (correct)

2 times more than plasma to brain tissue

5 times more than plasma to brain tissue

What form of Chloramphenicol is administered orally?

Palmitate ester Signup and view all the answers

Why should the dose of Chloramphenicol be adjusted in liver failure?

Because it is metabolized in the liver Signup and view all the answers

What concentration of Chloramphenicol is achieved in the CSF?

50% of the plasma concentration Signup and view all the answers

What is the mechanism of Fidaxomicin in treating C.difficile colitis?

Inhibiting protein synthesis Signup and view all the answers

What is a rare side effect of macrolides due to high doses?

Ototoxicity Signup and view all the answers

What is the reason for the interaction between erythromycin and digoxin?

Erythromycin reduces the bacteria that inactivate digoxin Signup and view all the answers

What is a common gastrointestinal side effect of macrolides?

Nausea and vomiting Signup and view all the answers

What is the name of the condition characterized by eosinophilia, fever, jaundice, and pain in the right upper quadrant of the abdomen?

Cholestatic hepatitis Signup and view all the answers

What is the effect of erythromycin on the serum concentration of digoxin?

Increases the serum concentration of digoxin Signup and view all the answers

What is the effect of erythromycin on gastric emptying?

It accelerates gastric emptying Signup and view all the answers

What is the pharmacological effect of macrolides on gastrointestinal motility?

They increase GI motility Signup and view all the answers

What is the mechanism of action of lincosamides?

They inhibit protein synthesis by binding to the 50S subunit of bacterial ribosomes Signup and view all the answers

What is the spectrum of activity of lincosamides?

Narrow spectrum, effective only against gram-positive bacteria Signup and view all the answers

What is the difference between lincomycin and clindamycin?

There is complete cross-resistance between lincomycin and clindamycin Signup and view all the answers

What is the effect of clindamycin on certain bacterial strains?

It is effective against some gram-positive bacteria, including Strep. Pneumoniae and Strep. Pyogenes Signup and view all the answers