Erythromycin's Effect on Diabetic Gastroparesis
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Questions and Answers

What is the bioavailability of Chloramphenicol?

  • 80%
  • 20%
  • 50%
  • Nearly 100% (correct)

What is the elimination half-life of Chloramphenicol?

  • 2 hours
  • 1 hour
  • 3 hours (correct)
  • 4 hours

Where does Chloramphenicol cross the blood-brain barrier most effectively?

  • 3 times more than plasma to brain tissue
  • 9 times more than plasma to brain tissue (correct)
  • 2 times more than plasma to brain tissue
  • 5 times more than plasma to brain tissue

What form of Chloramphenicol is administered orally?

<p>Palmitate ester (B)</p> Signup and view all the answers

Why should the dose of Chloramphenicol be adjusted in liver failure?

<p>Because it is metabolized in the liver (B)</p> Signup and view all the answers

What concentration of Chloramphenicol is achieved in the CSF?

<p>50% of the plasma concentration (B)</p> Signup and view all the answers

What is the mechanism of Fidaxomicin in treating C.difficile colitis?

<p>Inhibiting protein synthesis (D)</p> Signup and view all the answers

What is a rare side effect of macrolides due to high doses?

<p>Ototoxicity (A)</p> Signup and view all the answers

What is the reason for the interaction between erythromycin and digoxin?

<p>Erythromycin reduces the bacteria that inactivate digoxin (C)</p> Signup and view all the answers

What is a common gastrointestinal side effect of macrolides?

<p>Nausea and vomiting (A)</p> Signup and view all the answers

What is the name of the condition characterized by eosinophilia, fever, jaundice, and pain in the right upper quadrant of the abdomen?

<p>Cholestatic hepatitis (A)</p> Signup and view all the answers

What is the effect of erythromycin on the serum concentration of digoxin?

<p>Increases the serum concentration of digoxin (D)</p> Signup and view all the answers

What is the effect of erythromycin on gastric emptying?

<p>It accelerates gastric emptying (A)</p> Signup and view all the answers

What is the pharmacological effect of macrolides on gastrointestinal motility?

<p>They increase GI motility (A)</p> Signup and view all the answers

What is the mechanism of action of lincosamides?

<p>They inhibit protein synthesis by binding to the 50S subunit of bacterial ribosomes (A)</p> Signup and view all the answers

What is the spectrum of activity of lincosamides?

<p>Narrow spectrum, effective only against gram-positive bacteria (C)</p> Signup and view all the answers

What is the difference between lincomycin and clindamycin?

<p>There is complete cross-resistance between lincomycin and clindamycin (A)</p> Signup and view all the answers

What is the effect of clindamycin on certain bacterial strains?

<p>It is effective against some gram-positive bacteria, including Strep. Pneumoniae and Strep. Pyogenes (C)</p> Signup and view all the answers

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