Erythromycin's Effect on Diabetic Gastroparesis
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Questions and Answers

What is the bioavailability of Chloramphenicol?

  • 80%
  • 20%
  • 50%
  • Nearly 100% (correct)
  • What is the elimination half-life of Chloramphenicol?

  • 2 hours
  • 1 hour
  • 3 hours (correct)
  • 4 hours
  • Where does Chloramphenicol cross the blood-brain barrier most effectively?

  • 3 times more than plasma to brain tissue
  • 9 times more than plasma to brain tissue (correct)
  • 2 times more than plasma to brain tissue
  • 5 times more than plasma to brain tissue
  • What form of Chloramphenicol is administered orally?

    <p>Palmitate ester</p> Signup and view all the answers

    Why should the dose of Chloramphenicol be adjusted in liver failure?

    <p>Because it is metabolized in the liver</p> Signup and view all the answers

    What concentration of Chloramphenicol is achieved in the CSF?

    <p>50% of the plasma concentration</p> Signup and view all the answers

    What is the mechanism of Fidaxomicin in treating C.difficile colitis?

    <p>Inhibiting protein synthesis</p> Signup and view all the answers

    What is a rare side effect of macrolides due to high doses?

    <p>Ototoxicity</p> Signup and view all the answers

    What is the reason for the interaction between erythromycin and digoxin?

    <p>Erythromycin reduces the bacteria that inactivate digoxin</p> Signup and view all the answers

    What is a common gastrointestinal side effect of macrolides?

    <p>Nausea and vomiting</p> Signup and view all the answers

    What is the name of the condition characterized by eosinophilia, fever, jaundice, and pain in the right upper quadrant of the abdomen?

    <p>Cholestatic hepatitis</p> Signup and view all the answers

    What is the effect of erythromycin on the serum concentration of digoxin?

    <p>Increases the serum concentration of digoxin</p> Signup and view all the answers

    What is the effect of erythromycin on gastric emptying?

    <p>It accelerates gastric emptying</p> Signup and view all the answers

    What is the pharmacological effect of macrolides on gastrointestinal motility?

    <p>They increase GI motility</p> Signup and view all the answers

    What is the mechanism of action of lincosamides?

    <p>They inhibit protein synthesis by binding to the 50S subunit of bacterial ribosomes</p> Signup and view all the answers

    What is the spectrum of activity of lincosamides?

    <p>Narrow spectrum, effective only against gram-positive bacteria</p> Signup and view all the answers

    What is the difference between lincomycin and clindamycin?

    <p>There is complete cross-resistance between lincomycin and clindamycin</p> Signup and view all the answers

    What is the effect of clindamycin on certain bacterial strains?

    <p>It is effective against some gram-positive bacteria, including Strep. Pneumoniae and Strep. Pyogenes</p> Signup and view all the answers

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