Pharmacological Effects of Antihistamines Quiz
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Questions and Answers

Which characteristic of 1st generation antihistamines contributes to the drowsiness/sedation effect?

  • High lipid solubility
  • Fast onset of action
  • Low binding affinity to albumin
  • Ionization in physiological fluid (correct)

    • Why are 2nd generation antihistamines preferred for daytime use compared to 1st generation antihistamines?

  • Lower bioavailability
  • Higher lipid solubility
  • Increased alpha-adrenergic effects
  • Shorter plasma half-life (correct)

    • Which precaution is specifically mentioned for the use of diphenhydramine in patients with cardiovascular disease?

  • Increased bioavailability
  • Thickening of bronchiole secretions
  • Anti-muscarinic effects (correct)
  • Potential birth defects

    • How do first-generation antihistamines compare to second-generation antihistamines in terms of plasma half-life?

    <p>First-generation have longer half-life</p> Signup and view all the answers

    What is the main reason diphenhydramine is not recommended for daytime use?

    <p>Sedative effects</p> Signup and view all the answers

    Which receptor do 1st generation antihistamines block in addition to H1 receptors?

    <p>Serotonin</p> Signup and view all the answers

    What is a key difference between 1st generation and 2nd generation antihistamines in terms of sedation?

    <p>1st generation causes more CNS penetration</p> Signup and view all the answers

    Which generation of antihistamines is more selective for H1 receptors, leading to fewer autonomic effects?

    <p>2nd Generation</p> Signup and view all the answers

    Which of the following effects is NOT associated with the therapeutic uses of antihistamines?

    <p>Reducing vertigo</p> Signup and view all the answers

    Which statement accurately describes the pharmacokinetics of 2nd generation antihistamines?

    <p>They are less likely to cross the BBB</p> Signup and view all the answers

    What is the main difference between first generation and second generation antihistamines?

    <p>First generation antihistamines are less likely to cause drowsiness than second generation antihistamines.</p> Signup and view all the answers

    Which of the following is a first generation antihistamine?

    <p>Diphenhydramine</p> Signup and view all the answers

    What is the meaning of a 'prototype drug' in pharmacology?

    <p>The first drug developed in a particular class that represents the class as a whole.</p> Signup and view all the answers

    Which of the following is a therapeutic use of H1-receptor antagonists?

    <p>Relief of allergy symptoms</p> Signup and view all the answers

    What type of pharmacokinetic properties are important when considering H1-receptor antagonists?

    <p>Half-life and bioavailability</p> Signup and view all the answers

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