Podcast
Questions and Answers
Which characteristic of 1st generation antihistamines contributes to the drowsiness/sedation effect?
Which characteristic of 1st generation antihistamines contributes to the drowsiness/sedation effect?
- High lipid solubility
- Fast onset of action
- Low binding affinity to albumin
- Ionization in physiological fluid (correct)
Why are 2nd generation antihistamines preferred for daytime use compared to 1st generation antihistamines?
Why are 2nd generation antihistamines preferred for daytime use compared to 1st generation antihistamines?
- Lower bioavailability
- Higher lipid solubility
- Increased alpha-adrenergic effects
- Shorter plasma half-life (correct)
Which precaution is specifically mentioned for the use of diphenhydramine in patients with cardiovascular disease?
Which precaution is specifically mentioned for the use of diphenhydramine in patients with cardiovascular disease?
- Increased bioavailability
- Thickening of bronchiole secretions
- Anti-muscarinic effects (correct)
- Potential birth defects
How do first-generation antihistamines compare to second-generation antihistamines in terms of plasma half-life?
How do first-generation antihistamines compare to second-generation antihistamines in terms of plasma half-life?
What is the main reason diphenhydramine is not recommended for daytime use?
What is the main reason diphenhydramine is not recommended for daytime use?
Which receptor do 1st generation antihistamines block in addition to H1 receptors?
Which receptor do 1st generation antihistamines block in addition to H1 receptors?
What is a key difference between 1st generation and 2nd generation antihistamines in terms of sedation?
What is a key difference between 1st generation and 2nd generation antihistamines in terms of sedation?
Which generation of antihistamines is more selective for H1 receptors, leading to fewer autonomic effects?
Which generation of antihistamines is more selective for H1 receptors, leading to fewer autonomic effects?
Which of the following effects is NOT associated with the therapeutic uses of antihistamines?
Which of the following effects is NOT associated with the therapeutic uses of antihistamines?
Which statement accurately describes the pharmacokinetics of 2nd generation antihistamines?
Which statement accurately describes the pharmacokinetics of 2nd generation antihistamines?
What is the main difference between first generation and second generation antihistamines?
What is the main difference between first generation and second generation antihistamines?
Which of the following is a first generation antihistamine?
Which of the following is a first generation antihistamine?
What is the meaning of a 'prototype drug' in pharmacology?
What is the meaning of a 'prototype drug' in pharmacology?
Which of the following is a therapeutic use of H1-receptor antagonists?
Which of the following is a therapeutic use of H1-receptor antagonists?
What type of pharmacokinetic properties are important when considering H1-receptor antagonists?
What type of pharmacokinetic properties are important when considering H1-receptor antagonists?
