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Questions and Answers
What is the primary focus of pharmacokinetics?
Which parameter is crucial for understanding drug absorption?
What does ED50 represent in pharmacology?
How is bioavailability defined?
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What is the significance of the Volume of Distribution (Vd) in pharmacokinetics?
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Which of the following factors does not influence the route of drug administration?
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What is the typical unit for measuring Drug Concentration (C)?
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The AUC can be used to determine which of the following?
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Study Notes
Pharmacokinetics:
- "What the body does to the drug."
- Process includes:
- Absorption: Entry of drug into plasma from site of administration.
- Distribution: Drug travels from bloodstream into interstitial and intracellular fluids.
- Metabolism: Biotransformation by the liver or other tissues.
- Elimination: Removal of the drug and its metabolites in urine, bile, or feces.
Clinical Parameters in Drug Pharmacokinetics:
- Clinicians use pharmacokinetic parameters to:
- Determine the route of administration.
- Decide the amount and frequency of each dose.
- Determine the duration of treatment.
Dose Response Curve:
- Graphical representation relating drug concentration, amount, or dose to the receptor's response or drug effect.
- Measured dose plotted on the X axis, response plotted on the Y axis.
- ED50: Dose of a drug producing a specific effect in 50% of the population.
- Drugs typically interact with receptor proteins.
Key Pharmacokinetic Parameters:
-
Area under the Drugs Concentration Curve (AUC): Represents the total amount of drug absorbed.
- Crucial in defining how well the drug is absorbed.
- Required by FDA for drug approval.
- Unit: mg*h/ L.
-
Bioavailability (BA, F): Fraction of administered drug reaching systemic circulation unchanged.
- Calculated as: AUC(oral)/ AUC(IV) X 100
-
Drug Concentration (C): Amount of drug in a given volume of plasma.
- Unit: mg/l.
-
Volume of Distribution (Vd): Estimates the degree of drug penetration into different fluid compartments of the body.
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Description
Test your understanding of pharmacokinetics, focusing on how the body interacts with drugs through absorption, distribution, metabolism, and elimination. This quiz also covers the clinical parameters and dose-response curves essential for drug administration. Dive into key concepts and improve your knowledge in pharmacology.
