Pharmacokinetics Overview Quiz

Pharmacokinetics:

• "What the body does to the drug."
• Process includes:
  • Absorption: Entry of drug into plasma from site of administration.
  • Distribution: Drug travels from bloodstream into interstitial and intracellular fluids.
  • Metabolism: Biotransformation by the liver or other tissues.
  • Elimination: Removal of the drug and its metabolites in urine, bile, or feces.

Clinical Parameters in Drug Pharmacokinetics:

• Clinicians use pharmacokinetic parameters to:
  • Determine the route of administration.
  • Decide the amount and frequency of each dose.
  • Determine the duration of treatment.

Dose Response Curve:

• Graphical representation relating drug concentration, amount, or dose to the receptor's response or drug effect.
• Measured dose plotted on the X axis, response plotted on the Y axis.
• ED50: Dose of a drug producing a specific effect in 50% of the population.
• Drugs typically interact with receptor proteins.

Key Pharmacokinetic Parameters:

• Area under the Drugs Concentration Curve (AUC): Represents the total amount of drug absorbed.

  • Crucial in defining how well the drug is absorbed.
  • Required by FDA for drug approval.
  • Unit: mg*h/ L.

• Bioavailability (BA, F): Fraction of administered drug reaching systemic circulation unchanged.

  • Calculated as: AUC(oral)/ AUC(IV) X 100

• Drug Concentration (C): Amount of drug in a given volume of plasma.

  • Unit: mg/l.

• Volume of Distribution (Vd): Estimates the degree of drug penetration into different fluid compartments of the body.

Test your understanding of pharmacokinetics, focusing on how the body interacts with drugs through absorption, distribution, metabolism, and elimination. This quiz also covers the clinical parameters and dose-response curves essential for drug administration. Dive into key concepts and improve your knowledge in pharmacology.