Pharmacokinetics and Uses of H2 Antagonists and Proton Pump Inhibitors

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Which of the following conditions can be treated with H2 antagonists?

Stress ulcer (correct)

Anemia

Migraine

Pancreatitis

What is a common adverse effect of Proton Pump Inhibitors (PPIs)?

Increased appetite

Headache (correct)

Hair growth

Weight loss

How do Proton Pump Inhibitors (PPIs) act on parietal cells?

They enhance the release of bicarbonate

They inhibit the secretion of pepsin

They increase the production of HCL

They irreversibly inactivate the H+/K+ATPase pump (correct)

Which of the following conditions is NOT listed as a use for H2 antagonists?

Asthma Signup and view all the answers

What is the intermediate compound formed in acid media that effectively inhibits the H+ / K+ ATPase?

Sulphenamide Signup and view all the answers

Why are oral formulations of these drugs enteric coated?

To prevent acid inactivation in the stomach Signup and view all the answers

Which adverse effect is commonly associated with prolonged administration of Proton Pump Inhibitors (PPIs)?

Vitamin B12 deficiency Signup and view all the answers

What is a potential consequence of prolonged acid suppression by PPIs in relation to bacterial growth?

Bacterial overgrowth in smooth muscles Signup and view all the answers

What is the primary physiological factor that prevents the mucosa described in the text?

Ability to secrete mucus Signup and view all the answers

Which of the following pathways does histamine act through for gastric acid secretion control?

Local release of histamine Signup and view all the answers

Which drug classification includes Omeprazole and Pantoprazole among its members?

Proton pump inhibitors Signup and view all the answers

What is the primary mechanism of action of Sucralfate and Colloidal Bismuth Sulfate (CBS) as ulcer protectives?

Protect the mucosa from further damage Signup and view all the answers

What is the primary mechanism of action of Proton Pump Inhibitors (PPIs)?

Irreversibly inactivate the parietal cell H+/K+ ATPase Signup and view all the answers

Which of the following is a common adverse effect associated with Proton Pump Inhibitors (PPIs)?

Headache Signup and view all the answers

What is a characteristic of the pharmacokinetics of Proton Pump Inhibitors (PPIs)?

Reach milk and cross the placental barrier Signup and view all the answers

Which of the following actions best describes how Proton Pump Inhibitors (PPIs) work within the parietal cell canaliculi?

Inactivate H+/K+ ATPase irreversibly Signup and view all the answers

Which Proton Pump Inhibitor (PPI) is claimed to have the most rapid onset of action?

Pantoprazole Signup and view all the answers

What is a potential consequence of Omeprazole inhibiting the metabolism of certain drugs?

Increased risk of drug toxicity Signup and view all the answers

Which Proton Pump Inhibitor (PPI) has a higher bioavailability and better intra-gastric pH among the listed options?

Esomeprazole Signup and view all the answers

What distinguishes Lansoprazole among the Proton Pump Inhibitors (PPIs) in terms of potency?

More potent Signup and view all the answers

What is the reason for the action of Proton Pump Inhibitors (PPIs) lasting 3-4 days even after stopping the drug?

Interactions with cysteine residues Signup and view all the answers

Why are oral formulations of Proton Pump Inhibitors (PPIs) enteric coated?

To prevent acid inactivation in the stomach Signup and view all the answers

Which adverse effect is commonly associated with Prolonged administration of Proton Pump Inhibitors (PPIs)?

Atrophic changes in the stomach Signup and view all the answers

How do Proton Pump Inhibitors (PPIs) interact with the H+ / K+ ATPase to inhibit its activity?

Covalently interacting with cysteine residues Signup and view all the answers