Pharmacokinetics and Uses of H2 Antagonists and Proton Pump Inhibitors
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Questions and Answers

Which of the following conditions can be treated with H2 antagonists?

  • Stress ulcer (correct)
  • Anemia
  • Migraine
  • Pancreatitis

What is a common adverse effect of Proton Pump Inhibitors (PPIs)?

  • Increased appetite
  • Headache (correct)
  • Hair growth
  • Weight loss

How do Proton Pump Inhibitors (PPIs) act on parietal cells?

  • They enhance the release of bicarbonate
  • They inhibit the secretion of pepsin
  • They increase the production of HCL
  • They irreversibly inactivate the H+/K+ATPase pump (correct)

Which of the following conditions is NOT listed as a use for H2 antagonists?

<p>Asthma (A)</p> Signup and view all the answers

What is the intermediate compound formed in acid media that effectively inhibits the H+ / K+ ATPase?

<p>Sulphenamide (A)</p> Signup and view all the answers

Why are oral formulations of these drugs enteric coated?

<p>To prevent acid inactivation in the stomach (D)</p> Signup and view all the answers

Which adverse effect is commonly associated with prolonged administration of Proton Pump Inhibitors (PPIs)?

<p>Vitamin B12 deficiency (D)</p> Signup and view all the answers

What is a potential consequence of prolonged acid suppression by PPIs in relation to bacterial growth?

<p>Bacterial overgrowth in smooth muscles (C)</p> Signup and view all the answers

What is the primary physiological factor that prevents the mucosa described in the text?

<p>Ability to secrete mucus (D)</p> Signup and view all the answers

Which of the following pathways does histamine act through for gastric acid secretion control?

<p>Local release of histamine (A)</p> Signup and view all the answers

Which drug classification includes Omeprazole and Pantoprazole among its members?

<p>Proton pump inhibitors (C)</p> Signup and view all the answers

What is the primary mechanism of action of Sucralfate and Colloidal Bismuth Sulfate (CBS) as ulcer protectives?

<p>Protect the mucosa from further damage (C)</p> Signup and view all the answers

What is the primary mechanism of action of Proton Pump Inhibitors (PPIs)?

<p>Irreversibly inactivate the parietal cell H+/K+ ATPase (C)</p> Signup and view all the answers

Which of the following is a common adverse effect associated with Proton Pump Inhibitors (PPIs)?

<p>Headache (D)</p> Signup and view all the answers

What is a characteristic of the pharmacokinetics of Proton Pump Inhibitors (PPIs)?

<p>Reach milk and cross the placental barrier (A)</p> Signup and view all the answers

Which of the following actions best describes how Proton Pump Inhibitors (PPIs) work within the parietal cell canaliculi?

<p>Inactivate H+/K+ ATPase irreversibly (C)</p> Signup and view all the answers

Which Proton Pump Inhibitor (PPI) is claimed to have the most rapid onset of action?

<p>Pantoprazole (D)</p> Signup and view all the answers

What is a potential consequence of Omeprazole inhibiting the metabolism of certain drugs?

<p>Increased risk of drug toxicity (D)</p> Signup and view all the answers

Which Proton Pump Inhibitor (PPI) has a higher bioavailability and better intra-gastric pH among the listed options?

<p>Esomeprazole (C)</p> Signup and view all the answers

What distinguishes Lansoprazole among the Proton Pump Inhibitors (PPIs) in terms of potency?

<p>More potent (A)</p> Signup and view all the answers

What is the reason for the action of Proton Pump Inhibitors (PPIs) lasting 3-4 days even after stopping the drug?

<p>Interactions with cysteine residues (C)</p> Signup and view all the answers

Why are oral formulations of Proton Pump Inhibitors (PPIs) enteric coated?

<p>To prevent acid inactivation in the stomach (B)</p> Signup and view all the answers

Which adverse effect is commonly associated with Prolonged administration of Proton Pump Inhibitors (PPIs)?

<p>Atrophic changes in the stomach (B)</p> Signup and view all the answers

How do Proton Pump Inhibitors (PPIs) interact with the H+ / K+ ATPase to inhibit its activity?

<p>Covalently interacting with cysteine residues (D)</p> Signup and view all the answers

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