Pharmacokinetic Concepts Quiz
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Questions and Answers

Which phase of the pharmacokinetic process involves the movement of drug from the site of administration to the blood circulation?

  • Metabolism
  • Distribution
  • Absorption (correct)
  • Excretion
  • What term is commonly used to describe the rate and extent of drug input in the context of absorption?

  • Half-life
  • Distribution coefficient
  • Clearance
  • Bioavailability (correct)
  • Which route of drug administration exhibits essentially 100% bioavailability?

  • Intramuscular
  • Intravenous (correct)
  • Oral
  • Subcutaneous
  • What is the process by which a drug diffuses or transfers from intravascular to extravascular spaces (body tissues)?

    <p>Distribution</p> Signup and view all the answers

    What is metabolism in the context of pharmacokinetics?

    <p>The chemical conversion or transformation of drugs into compounds which are easier to eliminate</p> Signup and view all the answers

    Which phase of pharmacokinetics involves the elimination of unchanged drug or its metabolite from the body via renal, biliary, or pulmonary routes?

    <p>Excretion</p> Signup and view all the answers

    In the context of absorption, what does the term 'bioavailability' refer to?

    <p>The rate and extent of drug input</p> Signup and view all the answers

    What is the primary focus of pharmacokinetics?

    <p>Drug movement in the body</p> Signup and view all the answers

    Which factor does NOT affect drug absorption through the oral route?

    <p>ATP availability</p> Signup and view all the answers

    Why might change in formulation lead to altered clinical response for certain drugs?

    <p>Different bioavailability</p> Signup and view all the answers

    In which situation may oral paracetamol show a slow effect?

    <p>During dehydration</p> Signup and view all the answers

    What happens when certain drugs form complexes with food components?

    <p>Reduced bioavailability</p> Signup and view all the answers

    Why may insulin show a poor response after repeated injections in the same site?

    <p>Reduced absorption</p> Signup and view all the answers

    What is the process of drug distribution primarily concerned with?

    <p>Transfer of drugs between body compartments</p> Signup and view all the answers

    Which factor does NOT affect drug distribution within the body?

    <p>ATP production</p> Signup and view all the answers

    Why is blood flow to the liver important for certain drugs?

    <p>Enhanced metabolism</p> Signup and view all the answers

    What prevents many drug molecules from entering the surrounding tissue in brain capillaries?

    <p>Glial cells (lipid)</p> Signup and view all the answers

    Which protein is primarily responsible for binding many acidic drugs and a few basic drugs in circulating plasma?

    <p>Albumin</p> Signup and view all the answers

    Which factor can increase the fraction of unbound drug in the body?

    <p>Renal impairment</p> Signup and view all the answers

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