Pharmacokinetic Concepts Quiz

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Which phase of the pharmacokinetic process involves the movement of drug from the site of administration to the blood circulation?

Metabolism

Distribution

Absorption (correct)

Excretion

What term is commonly used to describe the rate and extent of drug input in the context of absorption?

Half-life

Distribution coefficient

Clearance

Bioavailability (correct)

Which route of drug administration exhibits essentially 100% bioavailability?

Intramuscular

Intravenous (correct)

Oral

Subcutaneous

What is the process by which a drug diffuses or transfers from intravascular to extravascular spaces (body tissues)?

Distribution Signup and view all the answers

What is metabolism in the context of pharmacokinetics?

The chemical conversion or transformation of drugs into compounds which are easier to eliminate Signup and view all the answers

Which phase of pharmacokinetics involves the elimination of unchanged drug or its metabolite from the body via renal, biliary, or pulmonary routes?

Excretion Signup and view all the answers

In the context of absorption, what does the term 'bioavailability' refer to?

The rate and extent of drug input Signup and view all the answers

What is the primary focus of pharmacokinetics?

Drug movement in the body Signup and view all the answers

Which factor does NOT affect drug absorption through the oral route?

ATP availability Signup and view all the answers

Why might change in formulation lead to altered clinical response for certain drugs?

Different bioavailability Signup and view all the answers

In which situation may oral paracetamol show a slow effect?

During dehydration Signup and view all the answers

What happens when certain drugs form complexes with food components?

Reduced bioavailability Signup and view all the answers

Why may insulin show a poor response after repeated injections in the same site?

Reduced absorption Signup and view all the answers

What is the process of drug distribution primarily concerned with?

Transfer of drugs between body compartments Signup and view all the answers

Which factor does NOT affect drug distribution within the body?

ATP production Signup and view all the answers

Why is blood flow to the liver important for certain drugs?

Enhanced metabolism Signup and view all the answers

What prevents many drug molecules from entering the surrounding tissue in brain capillaries?

Glial cells (lipid) Signup and view all the answers

Which protein is primarily responsible for binding many acidic drugs and a few basic drugs in circulating plasma?

Albumin Signup and view all the answers

Which factor can increase the fraction of unbound drug in the body?

Renal impairment Signup and view all the answers