Pharmacokinetic Compartment Modeling

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Questions and Answers

What is the formula for the concentration of a drug in a one-compartment model after an intravenous bolus dose?

C = C0/(1 - e^(-kt))
C = C0e^(-kt) (correct)
C = C0/(1 + e^(-kt))
C = C0e^(kt)

What is the name of the method used to determine the pharmacokinetic parameters of nanoparticles in vivo?

Non-compartmental analysis (correct)
Deconvolution method
Wagner-Nelson method
Compartmental modeling

What is the definition of Mean Residence Time (MRT) in a one-compartment model?

MRT = Vd / Cl
MRT = t1/2 / ln(2)
MRT = AUMC0-∞ / AUC0-∞ (correct)
MRT = AUC0-∞ / Cl

What is the formula for the area under the first moment curve (AUMC) in a one-compartment model?

AUMC = ∫[C(t) * t] dt from 0 to ∞ (D) Signup and view all the answers

What is the definition of Mean Absorption Time (MAT) in a non-instantaneous absorption model?

MAT = MRToral - MRTiv (B) Signup and view all the answers

What is the formula for the concentration of a drug in a one-compartment model after an oral dose?

C = (Fx * ka / (Vd * (ka - ke))) * (e^(-ket) - e^(-kat)) (C) Signup and view all the answers

What is the definition of the volume of distribution (Vd) in a one-compartment model?

Vd = AUC0-∞ / C0 (D) Signup and view all the answers

What is the purpose of pharmacokinetic modeling in nanoparticle delivery?

To determine the dose regimen of nanoparticles (C) Signup and view all the answers

What is the definition of the area under the curve (AUC) in a one-compartment model?

AUC = ∫[C(t)] dt from 0 to ∞ (C) Signup and view all the answers

What is the formula for the mean transit time (MTT) in a one-compartment model?

MTT = MRT + MAT (D) Signup and view all the answers

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