Pharmacodynamics and Drug Receptors
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Questions and Answers

What determines the concentration of a drug at its site of action?

  • Drug metabolism
  • Drug excretion routes
  • Pharmacodynamics (correct)
  • Pharmacokinetics
  • What type of molecule serves as drug binding targets in addition to proteins?

  • Steroids
  • DNA (correct)
  • Lipids
  • Carbohydrates
  • Which type of drug mimics the effects of endogenous regulators of the receptor it binds to?

  • Noncompetitive inhibitor
  • Antagonist
  • Competitive inhibitor
  • Agonist (correct)
  • What is the most common route for drug excretion?

    <p>Through the kidney and out of the body in urine</p> Signup and view all the answers

    What is the effect of an antagonist on the function of a receptor?

    <p>Prevents the effect of endogenous agonists</p> Signup and view all the answers

    What two important properties do pharmacologic antagonists have?

    <p>Do not elicit a biologic response in the absence of an agonist</p> Signup and view all the answers

    Why is it important for drugs to be reasonably hydrophilic for kidney excretion?

    <p>To facilitate their excretion in urine</p> Signup and view all the answers

    What impact does impaired kidney function have on drug elimination?

    <p>Reduces ability to eliminate hydrophilic drugs</p> Signup and view all the answers

    How can the effects of a competitive pharmacologic antagonist be overcome?

    <p>By adding more agonist</p> Signup and view all the answers

    Which organ is responsible for most of the enzymatic drug-metabolizing reactions?

    <p>Gastrointestinal tract and liver</p> Signup and view all the answers

    What is a common consequence of drugs inhibiting drug-metabolizing enzymes?

    <p>Increased drug-drug interactions</p> Signup and view all the answers

    According to pharmacology, what relationship exists between a drug's concentration at its site of action and its action?

    <p>A concentration-response relationship</p> Signup and view all the answers

    What does pharmacokinetics primarily concern?

    <p>The effects of the body on the administered drug</p> Signup and view all the answers

    Which of the following is NOT a process involved in pharmacokinetics?

    <p>Activation</p> Signup and view all the answers

    What is first-pass metabolism in relation to drug administration?

    <p>It refers to the metabolism of drugs before they enter the bloodstream</p> Signup and view all the answers

    Which route of drug administration allows for direct absorption into the systemic venous circulation?

    <p>Sublingual</p> Signup and view all the answers

    What can affect the rate and efficiency of drug absorption?

    <p>Gastric emptying and tablet disintegration</p> Signup and view all the answers

    Which process involves movement of drug molecules through different body compartments and barriers?

    <p>Distribution</p> Signup and view all the answers

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