Pharmaceutics Review: Oral Modified Release Systems

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Questions and Answers

What is the primary advantage of multiparticulate tablets over hard gelatin capsules?

Easy to manufacture

Require less raw material

Provide a sustained-release dosage form (correct)

Are cheaper to produce

What is the primary challenge of compacting coated multiparticulates into tablets?

The coats are expensive to produce

The functional polymer coat is damaged, resulting in a rapid release of the drug substance (correct)

The tablets are difficult to manufacture

The tablets are hard to swallow

What is the main benefit of incorporating multiparticulates into orodispersible matrices?

Improved manufacturing efficiency

Reduced swallowing difficulties (correct)

Enhanced patient adherence

Improved bioavailability

What type of dosage form is produced by compacting polymer-coated multiparticulates into tablets?

Sustained-release dosage form Signup and view all the answers

What is the focus of this review article?

The formulation variables influencing the compaction of coated multiparticulates into sustained-release tablets Signup and view all the answers

What is the author's affiliation in the corresponding email address?

Kingston University, School of Life Sciences, Pharmacy and Chemistry Signup and view all the answers

What is discussed separately in the review article for each of the following?

Coated drug-loaded pellets, microparticles, and nanoparticles Signup and view all the answers

What is evaluated in the various approaches discussed in the review article?

The compaction behaviour of particulate systems Signup and view all the answers

What is the primary limitation of conventional immediate-release dosage forms?

They fail to maintain stable plasma levels of drug over a prolonged period Signup and view all the answers

What is the estimated annual cost of hospitalization due to patient noncompliance in the United States?

$13.35 billion Signup and view all the answers

What is the estimated number of deaths caused by nonadherence to medication in the United States every year?

125,000 Signup and view all the answers

What is the primary advantage of once-daily dosage forms compared to thrice-daily dosage forms?

Increased patient compliance Signup and view all the answers

What is the objective of oral modified-release dosage forms?

To achieve a stable plasma level of drug over a prolonged period Signup and view all the answers

What is the limitation of multiple daily dosing for patients with chronic conditions?

It is inconvenient and can result in missed doses Signup and view all the answers

Why are oral modified-release dosage forms becoming increasingly popular?

They are more convenient and effective than traditional dosage forms Signup and view all the answers

What is the consequence of patients not adhering to their medication schedule?

Worsening of their condition Signup and view all the answers

Study Notes

Oral Modified Release Multiple-Unit Particulate Systems

Oral modified-release multiparticulate dosage forms are becoming increasingly popular for oral drug delivery applications.
These systems are also referred to as oral multiple-unit particulate systems.
Compaction of polymer-coated multiparticulates into tablets is preferred over hard gelatin capsules.

Advantages of Multiparticulate Tablets

Multiparticulate tablets are a promising solution to chronic conditions, patients' adherence, and swallowing difficulties.
They can be incorporated into orodispersible matrices to address these issues.

Challenges in Compaction

Compaction of multiparticulates often damages the functional polymer coat, leading to rapid release of the drug substance.
This results in the loss of sustained-release properties.

Focus of the Review

The review explores key formulation variables that influence the compaction of coated multiparticulates into sustained-release tablets.
It focuses on the tabletting of coated drug-loaded pellets, microparticles, and nanoparticles.
The review also evaluates the compaction behavior of particulate systems using various approaches.

Limitations of Conventional Immediate-Release Dosage Forms

Conventional immediate-release (IR) dosage forms fail to maintain stable plasma levels of drug over a prolonged period.
They generally have a short duration of action, necessitating multiple daily dosing.

Importance of Patient Compliance

Multiple daily dosing is undesirable and inconvenient for patients with chronic conditions, leading to missed doses or made-up doses.
In the United States, it is estimated that billions of dollars are spent every year due to the consequences of patient noncompliance.
Noncompliance can lead to serious consequences, including hospitalization and even death.

Benefits of Once-Daily Regimen

A once-daily regimen can improve patient adherence, with around 84% of patients complying with the medication schedule.
In contrast, a thrice-daily regimen is associated with lower adherence rates, around 59%.

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Description

This quiz reviews oral modified release multiple-unit particulate systems, including compressed pellets, microparticles, and nanoparticles. It covers the concepts and principles of pharmaceutics. Test your knowledge and understanding of this topic.