Introduction to Pharmaceutical Chemistry
50 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the log Pcalc value calculated for salicylic acid?

  • +0.95 (correct)
  • -0.7
  • +0.3
  • +1.2

    • Which functional group contributes the most to the hydrophilic character of a molecule?

  • -0.7
  • -1 (correct)
  • -1 (correct)
  • -0.85

    • Which of the following represents a lipophilic compound based on its log Pcalc value?

  • +1.0 (correct)
  • +0.4
  • +0.5
  • -0.1

    • What is the contribution of the phenyl group (C6H5-) to the calculation of log P?

    <p>2</p> Signup and view all the answers

    What is the total log Pcalc for chloramphenicol after summing all contributions?

    <p>2.02</p> Signup and view all the answers

    Which fragment contributes a positive value in the provided list of hydrophilic/lipophilic constants?

    <p>2</p> Signup and view all the answers

    Which of the following compounds is predicted to be water soluble?

    <p>0.3</p> Signup and view all the answers

    What does a positive contribution to log P generally indicate about a molecule?

    <p>1</p> Signup and view all the answers

    What does QSAR stand for in the context of predicting biological activity?

    <p>Quantitative Structure Activity Relationship</p> Signup and view all the answers

    Which parameter is crucial for estimating the biological activity of substances?

    <p>Oil-water distribution coefficient</p> Signup and view all the answers

    Which of the following is NOT a common acidic organic functional group?

    <p>Aliphatic amines (R-NH2)</p> Signup and view all the answers

    What does the ionization constant (ka) indicate?

    <p>The relative strength of an acid or base</p> Signup and view all the answers

    Which statement about acids is correct?

    <p>They contain a functional group that donates a proton (H+).</p> Signup and view all the answers

    Which of the following is a characteristic of basic organic functional groups?

    <p>They always accept protons.</p> Signup and view all the answers

    How does a stronger acid compare to a weaker acid based on their ionization constants?

    <p>It has a higher ka value.</p> Signup and view all the answers

    What factors influence the relative solubility of an organic molecule?

    <p>Differential contributions of structural features</p> Signup and view all the answers

    What is the importance of acidic and basic properties in pharmaceuticals?

    <p>They influence dosage formulations and pharmacological phases.</p> Signup and view all the answers

    Which functional groups typically enhance water solubility?

    <p>Nitrogen and oxygen containing functional groups</p> Signup and view all the answers

    What does the partition coefficient (P) represent?

    <p>The distribution of a compound between two solvents</p> Signup and view all the answers

    What is the formula for calculating the log of the partition coefficient?

    <p>Log Pcalc = ∑π</p> Signup and view all the answers

    What enhances lipid solubility in organic molecules?

    <p>Nonionizable hydrocarbon chains</p> Signup and view all the answers

    Which of the following is a characteristic of chloramphenicol?

    <p>Contains both lipophilic and hydrophilic groups</p> Signup and view all the answers

    What does the term hydrophilic refer to in the context of solubility?

    <p>Affinity for water</p> Signup and view all the answers

    What is represented by Σπ in the mathematical estimation of relative solubility?

    <p>The sum of hydrophilic-lipophilic constants</p> Signup and view all the answers

    Which acid is expected to be stronger based on its pKa value?

    <p>Acid with pKa 3</p> Signup and view all the answers

    What is the relationship between the pKa value and the strength of bases?

    <p>Higher pKa indicates a stronger base</p> Signup and view all the answers

    In the ionization of acetic acid, what ion is produced?

    <p>CH3COO-</p> Signup and view all the answers

    Which of the following correctly describes the formation of a salt?

    <p>It is formed from an acid and a base</p> Signup and view all the answers

    Which type of salt is formed by combining drug molecules with inorganic acids?

    <p>Inorganic salts</p> Signup and view all the answers

    What is the expected solubility of the salt form of a drug compared to its parent molecule?

    <p>More soluble</p> Signup and view all the answers

    Which functional group represents a weak acid that can ionize?

    <p>Carboxylic acid</p> Signup and view all the answers

    What is the formula for the equilibrium expression for the ionization of a weak acid?

    <p>Ka = [H+][A-]/[HA]</p> Signup and view all the answers

    What ion does ammonia produce when it acts as a base?

    <p>NH4+</p> Signup and view all the answers

    Which of the following compounds would be considered a weak base?

    <p>NH3</p> Signup and view all the answers

    How does stereochemistry impact pharmacological activity?

    <p>Changing stereospecificity can change pharmacological activity.</p> Signup and view all the answers

    What characterizes optical isomers?

    <p>They rotate polarized light differently.</p> Signup and view all the answers

    What is an example of a consequence of enantiomeric differences?

    <p>Different enantiomers can have vastly different potencies.</p> Signup and view all the answers

    What defines geometric isomerism?

    <p>It arises from restricted rotation around double bonds or ring systems.</p> Signup and view all the answers

    How do cis and trans isomers of diethylstilbestrol differ in pharmacological activity?

    <p>Trans has higher binding affinity for estrogen receptors than cis.</p> Signup and view all the answers

    What is meant by conformational isomerism?

    <p>It involves rotational differences about single bonds.</p> Signup and view all the answers

    Why do isomeric pairs differ in their pharmacological activity?

    <p>They interact differently with receptors.</p> Signup and view all the answers

    What effect does a change in stereospecificity have on drugs?

    <p>It can adversely affect pharmacological activity.</p> Signup and view all the answers

    Which conformation of acetylcholine binds to the muscarinic receptor?

    <p>Trans conformation</p> Signup and view all the answers

    What is the main purpose of bioisosterism in medicinal chemistry?

    <p>To maintain similar biological properties</p> Signup and view all the answers

    Which type of bioisosteres are known to be interchangeable due to size, shape, and electronic properties?

    <p>Classical bioisosteres</p> Signup and view all the answers

    Which compound was found to have twice the activity of another compound in the provided analogues?

    <p>Compound A</p> Signup and view all the answers

    What defines bioisosterism according to Friedman?

    <p>It involves compounds that possess the same biological activity.</p> Signup and view all the answers

    Which option describes non-classical bioisosteres?

    <p>Less straightforward in similarity</p> Signup and view all the answers

    Which of the following pairs is an example of isosteres?

    <p>N2O and CO2</p> Signup and view all the answers

    Why is isosterism significant in drug design?

    <p>To effectively resolve biological issues</p> Signup and view all the answers

    Study Notes

    Introduction to Pharmaceutical Chemistry

    • Pharmaceutical (Medicinal) Chemistry studies drugs from a chemical viewpoint, including design, synthesis, and structural analysis.
    • Medicinal Chemistry is an interdisciplinary science, encompassing various branches of chemistry and biology.
    • It involves isolating, characterizing, and synthesizing compounds for treating diseases, linking chemical structure to biological activity.
    • It contributes to organic chemistry (synthesis routes) and pharmacology (spectrum of action).
    • Medicinal chemistry leads to products like hormones, vitamins and biochemical drugs derived from biological sources.
    • It's viewed as an interdisciplinary research area combining chemistry and biology (e.g., synthetic chemistry, organic chemistry, biochemistry, pharmacology, molecular biology) to enhance drug discovery.
    • Medicinal chemistry entails discovering and designing new, enhanced therapeutic chemicals and developing them into medicines and drugs.

    Drug Classification

    • Pure organic compounds are primary agents for diseases, categorized by origin.
      • Natural compounds: Plant and animal sources (vitamins, hormones, amino acids, antibiotics, alkaloids).
      • Synthesis compounds: Created through pure synthesis or from naturally occurring compounds(morphine, atropine, steroids, cocaine) to decrease costs.
      • Semi-synthesis compounds: Combining natural intermediates to produce a desired product (e.g., semi-synthetic penicillins) due to high cost or isolation challenges.
    • Two main categories based on medicinal use:
      • Pharmacodynamic agents: Act on body's physiological functions (e.g., general anesthetics, hypnotics, sedatives, analgesics).
      • Chemotherapeutic agents: Target pathogenic agents (e.g., sulfonamides, antibiotics, antimalarials, antivirals, anticancer agents).

    Drugs and Diseases

    • Drugs treat various diseases:
      • Infectious diseases: Transmitted via agents including bacteria, viruses, fungi, and parasites.
      • Non-Infectious diseases: Stem from genetic factors, environment, aging, stress and more (e.g., diabetes, heart disease, cancer, etc.).
      • Non-diseases: Address pain relief (analgesics), pregnancy prevention (contraception), or anesthesia.

    Physicochemical Properties in Relation to Biological Action

    • Drugs typically interact with targets like proteins, enzymes, cell lipids, or DNA/RNA fragments.
    • The pharmacological effect of a compound is influenced by its physicochemical properties.
    • Key influential physicochemical properties of organic medicinal agents (OMAs) include:
      • Solubility
      • Acidity and basicity
      • Reactivity

    Importance of Solubility

    • Solubility is crucial for drug formulation (appropriate dosage form) and bio-disposition (absorption, distribution, metabolism, excretion).
    • Solubility is measured by affinity (or repulsion)/philicity(or phobicity) between the drug molecule and either an aqueous (hydrophilic) or lipid (lipophilic) solvent.

    Solubility Prediction (cont.)

    • Solubility of OMAs is a spectrum between high lipophilicity and high hydrophilicity.
    • A compound's solubility in a particular solvent is determined by attractive forces between the compound and solvent molecules.
    • It's possible to estimate OMAs' solubility (hydrophilic vs. lipophilic) by evaluating the structure (analyzing the presence of structural features promoting affinity for aqueous or lipid media).

    Intermolecular Attractive Forces

    • Essential intermolecular forces in the solubilization process are:
      • Van der Waals attraction: Weakest electrostatic force between nonpolar molecules (e.g., hydrocarbons).
      • Dipole-dipole bonding: Electrostatic linkage between electron deficient and rich atoms (e.g., hydrogen bonding).
      • Ionic bonding: Electrostatic attraction between cations and anions (found in inorganic salts and salts of organic molecules).
      • Ion-dipole interaction: Electrostatic interaction between an ion and a dipole (especially important for interactions between OMAs and water).

    Mathematical Estimation of Relative Solubility

    • Mathematical methods estimate solubility based on the differential contribution from various structural attributes.
    • Solubility prediction involves summing the contribution of each group and substituent.
    • Water-insoluble compounds (lipophilic) typically have log Pcalc values > +0.5.
    • Water-soluble compounds (hydrophilic) usually have log Pcalc values < +0.5.

    Laboratory Estimation of Relative Solubility

    • Relative solubility of an organic compound is determined by experimental measurement (partition coefficient).
    • This involves determining the extent of distribution between aqueous (usually pH 7.4 buffer) and lipid (typically n-octanol) solvents.
    • The calculated partition coefficient (P) signifies the relative distribution of the compound between the two solvents.

    QSAR

    • QSAR is a computational method for predicting the biological activity, toxicity, or physicochemical properties of a molecule based on its chemical structure.
    • It can aid in designing new molecules, reduce experimentation and estimate relative solubility of drugs.

    Acidity and Basicity

    • Acid/Base properties of OMAs is significant in both the pharmaceutical phase (dosage formulation) and the pharmacological phase (disposition and impact on target sites).
    • Acid/base recognition involves identifying acidic and basic organic functional groups and evaluating their relative acid/base strengths.
    • Identifying these groups is essential to determine the relative acid/base strength using ionization constants (Ka) and pKa.

    Salt Formation

    • Salt formation (combining an acid and base) elevates drug solubility compared to parent molecules.
      • Inorganic salts: Created by combining drug molecules with inorganic acids/bases(e.g., HCl, H2SO4, KOH, NaOH). Common usage is to increase the aqueous solubility.
      • Organic salts: Formed through combining an acidic and a basic drug molecule or combining a drug with organic acids/bases. Usage is to increase lipid solubility enabling depot injections.

    Drug Activity Classifications

    • Structurally Non-specific: Activity depends on physical properties like solubility, partition coefficients and vapor pressure and does not require explicit interaction with cellular targets.
    • Structurally Specific: Activity depends on functional group presence, 3D structure and the interaction between the drug and a cellular receptor.

    Drug-Receptor Interaction

    • Receptors are sites in a biological system where drugs exert their effects.
    • Most drugs function by interacting (combining) with receptors.
    • The strength of binding between a drug and a receptor is measured by the drug's affinity for the receptor.
    • Receptor concentration affects drug response.
    • Agonists initiate response after binding to a receptor.
    • Antagonists bind to a receptor but do not trigger response leading to blockage.

    Stereochemistry

    • Stereochemistry is critical in pharmacological properties.
      • Differences in stereospecificity(the specific 3D arrangement of atoms) affect activity.
      • Enantiomers (mirror image isomers) exhibit significant differences in potency, receptor fit, biological action, transport, and metabolism.
        • Example: Levophanol has various pharmacological properties while dextrophanol has a limited set of effects.
      • Geometric isomers (cis-trans) have different activity due to varied physical properties and differences in receptor fit.
      • Conformational isomers result from rotating around single bonds, and different conformations may exhibit different receptor binding capabilities.
        • Example: Acetylcholine exists in different conformations with distinct receptor binding.
    • Isosterism and Bioisosterism: The process of creating structural analogues where substituted atoms or groups have similar properties to the parent molecule. This helps in maintaining biological activity while adjusting other properties like potency or side effects.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Related Documents

    Introduction To Pharmaceutical Chemistry PDF

    Description

    This quiz explores the fundamentals of Pharmaceutical Chemistry, focusing on the design, synthesis, and analysis of drugs from a chemical perspective. It highlights the interdisciplinary nature of this field, linking chemistry and biology in the context of drug discovery and development. Ideal for students interested in understanding how medicinal chemistry impacts healthcare.

    More Like This

    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser