15 Questions
What is the first task in many drug discovery programs?
Identify one or more lead compounds
What is the primary characteristic of a lead compound?
It shows desired pharmaceutical activity, although it may not be very great
What is the purpose of modifying the structure of a lead compound?
To avoid patent restrictions and retain the activity
What was the improvement in antihistaminics introduced in 1980?
Lower tendency to cause sedation
What is the difference between extensive screening and random screening?
Extensive screening involves a large number of experimental models, while random screening involves a limited number of molecules
What was made possible in 1980 in terms of drug discovery?
Combining extensive screening and random screening
What is the primary goal of lead optimization?
To improve the pharmacokinetic and pharmacodynamic properties of a lead compound
What is the characteristic of a molecule that is considered a lead compound?
It shows the desired pharmaceutical activity
What is the purpose of extensive screening in drug discovery?
To study a limited number of molecules in a thorough manner
What is the advantage of modifying the structure of a lead compound?
It avoids patent restrictions
What is the outcome of improving the therapeutic properties of a lead compound?
Increased potency and reduced daily dose
What is the difference between a lead compound and a new drug?
A lead compound is a molecule with desired pharmaceutical activity, while a new drug is a optimized lead compound
What is the advantage of random screening in drug discovery?
It can identify potential leads quickly and efficiently
What is the outcome of avoiding certain side effects of a lead compound?
Improved therapeutic properties and reduced side effects
What is the purpose of discovering a new drug?
To treat a specific disease or condition
Learn about the process of drug design, from identifying lead compounds to optimizing their pharmacokinetic and pharmacodynamic properties. Test your understanding of this crucial step in discovering new drugs.
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