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Pharmaceuticals: Drug Design and Development

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Pharmaceuticals: Drug Design and Development

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Questions and Answers

What is the first task in many drug discovery programs?

Conduct extensive screening of new chemical entities

Improve the pharmacokinetic and pharmacodynamic properties of the lead compound

Modify the structure of the lead compound to avoid patent restrictions

Identify one or more lead compounds (correct)

What is the primary characteristic of a lead compound?

It has a large number of experimental models

It shows desired pharmaceutical activity, although it may not be very great (correct)

It has a low tendency to cause sedation

It has a high potency and minimal side effects

What is the purpose of modifying the structure of a lead compound?

To introduce new biological targets

To increase the potency of the compound

To reduce the daily dose of the compound

To avoid patent restrictions and retain the activity (correct)

What was the improvement in antihistaminics introduced in 1980?

Lower tendency to cause sedation Signup and view all the answers

What is the difference between extensive screening and random screening?

Extensive screening involves a large number of experimental models, while random screening involves a limited number of molecules Signup and view all the answers

What was made possible in 1980 in terms of drug discovery?

Combining extensive screening and random screening Signup and view all the answers

What is the primary goal of lead optimization?

To improve the pharmacokinetic and pharmacodynamic properties of a lead compound Signup and view all the answers

What is the characteristic of a molecule that is considered a lead compound?

It shows the desired pharmaceutical activity Signup and view all the answers

What is the purpose of extensive screening in drug discovery?

To study a limited number of molecules in a thorough manner Signup and view all the answers

What is the advantage of modifying the structure of a lead compound?

It avoids patent restrictions Signup and view all the answers

What is the outcome of improving the therapeutic properties of a lead compound?

Increased potency and reduced daily dose Signup and view all the answers

What is the difference between a lead compound and a new drug?

A lead compound is a molecule with desired pharmaceutical activity, while a new drug is a optimized lead compound Signup and view all the answers

What is the advantage of random screening in drug discovery?

It can identify potential leads quickly and efficiently Signup and view all the answers

What is the outcome of avoiding certain side effects of a lead compound?

Improved therapeutic properties and reduced side effects Signup and view all the answers

What is the purpose of discovering a new drug?

To treat a specific disease or condition Signup and view all the answers