Podcast
Questions and Answers
What is the first task in many drug discovery programs?
What is the first task in many drug discovery programs?
- Conduct extensive screening of new chemical entities
- Improve the pharmacokinetic and pharmacodynamic properties of the lead compound
- Modify the structure of the lead compound to avoid patent restrictions
- Identify one or more lead compounds (correct)
What is the primary characteristic of a lead compound?
What is the primary characteristic of a lead compound?
- It has a large number of experimental models
- It shows desired pharmaceutical activity, although it may not be very great (correct)
- It has a low tendency to cause sedation
- It has a high potency and minimal side effects
What is the purpose of modifying the structure of a lead compound?
What is the purpose of modifying the structure of a lead compound?
- To introduce new biological targets
- To increase the potency of the compound
- To reduce the daily dose of the compound
- To avoid patent restrictions and retain the activity (correct)
What was the improvement in antihistaminics introduced in 1980?
What was the improvement in antihistaminics introduced in 1980?
What is the difference between extensive screening and random screening?
What is the difference between extensive screening and random screening?
What was made possible in 1980 in terms of drug discovery?
What was made possible in 1980 in terms of drug discovery?
What is the primary goal of lead optimization?
What is the primary goal of lead optimization?
What is the characteristic of a molecule that is considered a lead compound?
What is the characteristic of a molecule that is considered a lead compound?
What is the purpose of extensive screening in drug discovery?
What is the purpose of extensive screening in drug discovery?
What is the advantage of modifying the structure of a lead compound?
What is the advantage of modifying the structure of a lead compound?
What is the outcome of improving the therapeutic properties of a lead compound?
What is the outcome of improving the therapeutic properties of a lead compound?
What is the difference between a lead compound and a new drug?
What is the difference between a lead compound and a new drug?
What is the advantage of random screening in drug discovery?
What is the advantage of random screening in drug discovery?
What is the outcome of avoiding certain side effects of a lead compound?
What is the outcome of avoiding certain side effects of a lead compound?
What is the purpose of discovering a new drug?
What is the purpose of discovering a new drug?
