20 Questions
Who is known as the man who pioneered the use of minerals and other chemicals in medicine?
Paracelsus
According to Paracelsus, what differentiates poisons from remedies?
Dose
What did Percival Pott discover about chimney sweeps?
They had a higher risk of scrotal cancer
How did Hemlock cause death according to the information provided?
It blocks protein synthesis
Which toxic substance inhibits acetylcholinesterase, leading to excess acetylcholine & hyperstimulation?
Sarin
What is the toxic ingredient found in Pufferfish that blocks voltage gated Na channels?
Tetrodotoxin
Which hazard has the potential to cause harm but is not specified in the text?
Tetrodotoxin
What process involves the evaluation of information to determine possible risks associated with exposure to toxic chemicals?
Risk Characterization
What is the purpose of Hazard Evaluation or Dose-Response Assessment?
To calculate the dose-effect and include safety factors.
What information should Hazard Identification provide according to the text?
Whether exposure causes adverse effects.
What is the toxic ingredient found in Cyanide Capsules that inhibits ATP production?
Arsenic
What neurological symptoms are associated with Minamata Disease caused by methyl mercury toxicity?
Muscle weakness and coma
What is the mechanism of action of Sarin, as used by Saddam Hussein and in the Japanese Subway Sarin attack?
Suppresses neurotransmission
What is the primary purpose of Hazard Identification in the Risk Assessment process?
Collect data on adverse effects of exposure
Which organophosphorus chemical warfare agent inhibits acetylcholinesterase, leading to hyperstimulation of nerves?
VX
Who is credited with compiling a listing of poisons and outlining some clinical toxicology principles around 400 BC?
Hippocrates
What is the traditional definition of Toxicology as described in the text?
Study of adverse effects of chemicals or physical agents on living organisms.
What did Percival Pott find out about chimney sweeps in 1775?
Soot caused scrotal cancer in them.
Which toxic ingredient found in Death Cap Mushrooms leads to liver failure, kidney failure, coma, and death?
Alpha-amanitin
Which historical figure died from eating Death Cap Mushrooms?
Charles VI
Explore the history and primary goal of pharmaceutical toxicology, focusing on ensuring drug safety for human use. Learn about the traditional definition of toxicology as the study of poisons and its evolution into the study of adverse effects of chemicals and physical agents on living organisms. Discover key figures like Paracelsus and Hippocrates in the development of toxicology.
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