16 Questions
What is the mechanism of action of Mupirocin?
Binds with and inhibits isoleucine synthetase enzyme
Which bacteria are targeted by Mupirocin?
Gram-positive bacteria only
What is the basis for the inhibition of protein synthesis by Mupirocin?
Structural similarity between mupirocin molecule and isoleucine
Which gene mutation can lead to resistance to Mupirocin?
Mutation in gene of isoleucine synthetase
How are Tetracyclines and Glycylcyclines composed?
Four hexagonal rings with various side groups
What is the spectrum of application for Tetracyclines and Glycylcyclines?
Narrow spectrum, effective against Gram-positive bacteria only
Which mechanism of resistance to aminoglycosides involves the production of inactivation enzymes?
Aminoglycoside acetyltransferase (ACC): AG + acetyl CoA
Which drug binds to the 50S ribosomal subunit to prevent the formation of the initiation complex?
Chloramphenicol
What is the main route of administration for Oxazolidinones like Linezolid?
Oral
Which of the following is NOT a drug affecting the 50S ribosomal subunit?
Aminoglycosides
What is the main reason for using the combination of drugs discussed in the text?
To achieve 'double sequential blockade' of folic acid synthesis
Which of the following is a key advantage of co-trimoxazole highlighted in the text?
Effective treatment for uncomplicated lower UTIs
What is the mechanism of action (MOA) of Rifamycins like rifampicin?
Preventing transcription initiation by binding to bacterial RNA polymerase
Which type of bacteria is rifampicin particularly active against?
Mycobacterium tuberculosis
What makes rifampicin useful in the treatment of tuberculous meningitis?
Good penetration into cerebrospinal fluid
Which statement best describes the bactericidal effect of rifampicin?
It is most effective against Mycobacterium tuberculosis
Test your knowledge on the bactericidal activity of co-trimoxazole, advantages, and use in the treatment of uncomplicated lower UTIs and prophylaxis against recurrent UTIs. This quiz is based on lecture notes from Pharmaceutical Microbiology & Antimicrobials (CCS312) by Dr. Mohammed E.
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