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Pharmaceutical Microbiology: Co-trimoxazole Bactericidal Activity Quiz

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Pharmaceutical Microbiology: Co-trimoxazole Bactericidal Activity Quiz

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Questions and Answers

What is the mechanism of action of Mupirocin?

Activates the 30S ribosomal subunit

Inhibits DNA replication

Binds with and inhibits isoleucine synthetase enzyme (correct)

Inhibits RNA synthesis

Which bacteria are targeted by Mupirocin?

Gram-negative bacteria only

Gram-positive bacteria only (correct)

Anaerobic bacteria

Gram-positive and Gram-negative bacteria

What is the basis for the inhibition of protein synthesis by Mupirocin?

Structural similarity between mupirocin molecule and DNA

Structural similarity between mupirocin molecule and RNA

Structural similarity between mupirocin molecule and isoleucine (correct)

Structural similarity between mupirocin molecule and the 30S ribosomal subunit

Which gene mutation can lead to resistance to Mupirocin?

Mutation in gene of isoleucine synthetase Signup and view all the answers

How are Tetracyclines and Glycylcyclines composed?

Four hexagonal rings with various side groups Signup and view all the answers

What is the spectrum of application for Tetracyclines and Glycylcyclines?

Narrow spectrum, effective against Gram-positive bacteria only Signup and view all the answers

Which mechanism of resistance to aminoglycosides involves the production of inactivation enzymes?

Aminoglycoside acetyltransferase (ACC): AG + acetyl CoA Signup and view all the answers

Which drug binds to the 50S ribosomal subunit to prevent the formation of the initiation complex?

Chloramphenicol Signup and view all the answers

What is the main route of administration for Oxazolidinones like Linezolid?

Oral Signup and view all the answers

Which of the following is NOT a drug affecting the 50S ribosomal subunit?

Aminoglycosides Signup and view all the answers

What is the main reason for using the combination of drugs discussed in the text?

To achieve 'double sequential blockade' of folic acid synthesis Signup and view all the answers

Which of the following is a key advantage of co-trimoxazole highlighted in the text?

Effective treatment for uncomplicated lower UTIs Signup and view all the answers

What is the mechanism of action (MOA) of Rifamycins like rifampicin?

Preventing transcription initiation by binding to bacterial RNA polymerase Signup and view all the answers

Which type of bacteria is rifampicin particularly active against?

Mycobacterium tuberculosis Signup and view all the answers

What makes rifampicin useful in the treatment of tuberculous meningitis?

Good penetration into cerebrospinal fluid Signup and view all the answers

Which statement best describes the bactericidal effect of rifampicin?

It is most effective against Mycobacterium tuberculosis Signup and view all the answers