Cold Sterilization Methods in Pharmaceutical Microbiology

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5 Questions

What is the main mechanism of action of ethylene oxide gas in sterilization?

Alkylation of hydroxyl and carboxyl groups of proteins and nucleic acids

What is the recommended concentration range for ethylene oxide gas in sterilization?

800-1200 mg/L

At what relative humidity level does the activity of ethylene oxide gas decrease?

< 30%

Which material does ethylene oxide gas not penetrate during sterilization?

Glass

What is the temperature range for ethylene oxide gas in sterilization?

45-63°C

Study Notes

Ethylene Oxide Gas Sterilization

  • The main mechanism of action of ethylene oxide gas is alkylating cell components, particularly DNA, to disrupt microbial metabolism and eventually kill microorganisms.
  • The recommended concentration range for ethylene oxide gas in sterilization is 450-1200 mg/L.
  • The activity of ethylene oxide gas decreases at a relative humidity level below 30%.
  • Ethylene oxide gas does not penetrate certain materials, such as rubber and some plastics, during sterilization.
  • The temperature range for ethylene oxide gas in sterilization is 49-63°C (120-145°F).

Test your knowledge of cold sterilization methods in pharmaceutical microbiology with this quiz. Explore gas sterilization, radiation, and filtration techniques, as well as their applications in sterilizing surgical instruments, medical equipment, and powders.

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