Pharmaceutical Manufacturing: Tablets & Solid Dosage Forms

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What is the primary objective of the tablet granulation process?

To add flavors to the tablet
To reduce the size of the drug substance
To increase the density of the tablet
To improve the flow properties of the powder (correct)

What are the two main types of tablets?

Coated and uncoated tablets
Capsules and pills
Soft and hard gelatin capsules
Molded and compressed tablets (correct)

What is the purpose of additives in tablet manufacturing?

To add color to the tablet
To improve the flow properties of the powder (correct)
To enhance the bioavailability of the drug
To increase the shelf life of the tablet

What is the primary function of a tableting machine?

To compress the powder mixture into a tablet (B) Signup and view all the answers

What is the primary concern during tablet processing?

Inconsistent tablet weight (A) Signup and view all the answers

What is the primary purpose of tablet coating?

To control the release of the drug (D) Signup and view all the answers

What is one of the reasons for tablet coating?

To facilitate handling in high-speed packaging lines (B) Signup and view all the answers

What is the primary purpose of sealing in the sugar coating procedure?

To strengthen the tablet core (B) Signup and view all the answers

What is the result of the modification of drug release in enteric-coated tablets?

Delayed release of the drug (C) Signup and view all the answers

What type of polymers are commonly used as tablet sealants?

Water-insoluble polymers (A) Signup and view all the answers

What is the name of the commonly used tablet sealant that is best in combination with PVP?

Shellac (C) Signup and view all the answers

What is the function of electric heater or gas in a sugar coating machine?

To heat the solution (B) Signup and view all the answers

What is the process of applying multiple layers of sugar in sugar coating?

Coating (A) Signup and view all the answers

What is the benefit of using a sugar coating machine that performs dual functions of sugar and film coating?

Uniform application of coats (A) Signup and view all the answers

What is the final step in the sugar coating process?

Drying and cooling with uniform finishing (B) Signup and view all the answers

What is the main purpose of the company's closed and high-containment principle?

To prevent substances escaping from the machinery and contaminating the surroundings (D) Signup and view all the answers

What is the final step in the sugar coating procedure?

Printing (A) Signup and view all the answers

What is the traditional method of color-coating?

Using water-soluble dyes (B) Signup and view all the answers

What is the purpose of polishing in sugar coating?

To provide aesthetic appeal and high gloss (A) Signup and view all the answers

What is the method of printing used for identification?

Offset rotogravure (C) Signup and view all the answers

What is the advantage of automatic control devices in syrup application?

They allow programmed variation in dose volume, rolling time, and drying time (D) Signup and view all the answers

What is the primary purpose of adding coloring agents to tablet granulations?

To improve the aesthetic appearance of the product (A) Signup and view all the answers

What is the ideal characteristic of sugar-coated tablets?

Perfectly smooth rounded contour with even color coverage (A) Signup and view all the answers

What type of coating is usually made by a spray method?

Film coating (D) Signup and view all the answers

What is the most common method of adding a colorant to a tablet formulation?

To dissolve the dye in the binding solution (B) Signup and view all the answers

Which of the following is NOT a purpose of adding flavoring agents to tablet formulations?

To increase the bioavailability of the active ingredient (B) Signup and view all the answers