Pharmaceutical Dosage Forms Quiz

Questions and Answers

What is the purpose of using a subcoating on tablets?

To improve the dissolution rate in gastric fluid

To bond the sugar coating to the tablet and provide rounding (correct)

To increase the shelf life of the tablet

To enhance flavor and appearance

Which of the following materials is NOT used in enteric coatings?

Hydroxypropyl methylcellulose phthalate

Cellulose acetate phthalate

Shellac

Gelatin (correct)

Why are tablets packaged in tight containers with desiccant packets?

To avoid spoilage from moisture (correct)

To enhance the release of the active ingredient

To minimize the exposure to temperature changes

To protect against contamination from air

How do rapidly dissolving tablets differ from regular compressed immediate release tablets?

They tend to be softer and require special packaging Signup and view all the answers

What is the recommended storage condition for tablets sensitive to light?

In light-proof containers Signup and view all the answers

What is the primary use of buccal tablets?

To dissolve slowly for sustained drug release Signup and view all the answers

What characteristic is true of tablet triturates?

They must dissolve completely in water Signup and view all the answers

Which ingredient is commonly used as an excipient in chewable tablets?

Mannitol Signup and view all the answers

What is a main reason for the decline in the use of hypodermic tablets?

Difficulty in achieving sterility Signup and view all the answers

What is the recommended usage for chewable tablets?

To chew thoroughly before swallowing Signup and view all the answers

Effervescent tablets are characterized by their ability to:

Release gas upon contact with water Signup and view all the answers

Which statement is true regarding dispensing tablets?

Pharmacists use them to compound prescriptions Signup and view all the answers

What is the main characteristic of chewable tablets?

They disintegrate and dissolve quickly in the mouth Signup and view all the answers

What is the primary factor that affects tablet thickness?

The diameter of the die Signup and view all the answers

Which of the following systems is known as the fastest disintegrating tablet delivery system?

Zydis system Signup and view all the answers

What pressure range is common for tablet presses during production?

3,000 to 40,000 lb Signup and view all the answers

Which characteristic is crucial for tablet hardness that impacts disintegration and dissolution?

Force applied during compression Signup and view all the answers

Which of the following factors does NOT influence tablet hardness?

Tablet thickness measurement technique Signup and view all the answers

What is a common issue associated with rapidly disintegrating tablets?

Increased drug loading difficulties Signup and view all the answers

During quality testing, how long are extended-release tablets simulated in gastric fluid?

1 hour Signup and view all the answers

What is one potential disadvantage of rapidly disintegrating tablets?

Reduced stability of the product Signup and view all the answers

What is the primary purpose of wet granulation in the context of handling powders?

To form compact masses and reduce toxic dust generation Signup and view all the answers

What happens if insufficient binder is used during the wet granulation process?

The adhesion of the granules will be poor Signup and view all the answers

Which process is characterized by compressing powdered material directly into tablets without modifying its physical nature?

Direct compression Signup and view all the answers

What is the recommended drying temperature for wet granules during the drying process?

60°C Signup and view all the answers

What type of agents are included during the mixing of active ingredients and excipients in the direct compression process?

Active ingredients, excipients, lubricants, and glidants Signup and view all the answers

How are the dried granules processed after drying in the wet granulation method?

They are passed through Sieve 20 for uniformity Signup and view all the answers

What is a potential outcome of excessive binder solution in the wet granulation process?

Hard tablets with slower disintegration rate Signup and view all the answers

Which component is typically excluded when weighing and mixing for wet granulation?

Lubricants Signup and view all the answers

What is the primary purpose of immediate release tablets?

To disintegrate and release medication without special controls. Signup and view all the answers

Rapidly disintegrating or dissolving tablets are specifically intended for which type of patients?

Patients who have difficulty swallowing traditional tablets. Signup and view all the answers

What technique is used in the preparation of rapidly disintegrating/dissolving tablets?

Soft direct compression and lyophilization. Signup and view all the answers

What is a key feature of vaginal tablets/vaginal inserts?

They are shaped to snugly fit inserter devices. Signup and view all the answers

What is the acceptable range for content uniformity according to the USP method?

85% to 115% of the label claim. Signup and view all the answers

What is one advantage of rapidly disintegrating/dissolving tablets over traditional oral liquids?

They are more convenient to carry and administer. Signup and view all the answers

What characterizes rapidly disintegrating or dissolving tablets?

They liquefy on the tongue within a short time. Signup and view all the answers

What risk is associated with tablets containing highly potent drug substances?

They can lead to inaccurate dosing when compounded. Signup and view all the answers

Study Notes

Tablet Types and Characteristics

Buccal Tablets: Designed for slow erosion; used for sublingual applications like nitroglycerin.
Sublingual Tablets: Must dissolve quickly for rapid drug effect; tablet triturates require minimal pressure during manufacture and are soluble in water.
Chewable Tablets: Provide smooth disintegration when chewed; typically flavored and colored with mannitol; aids administration for those with swallowing difficulties.
Hypodermic Tablets: Used for extemporaneous preparation of injectable solutions but less common now due to the availability of sterile products.
Effervescent Tablets: Contain granular salts that release gas when mixed with water, assisting in drug dissolution.
Immediate Release Tablets: Disintegrate rapidly without special controls; suitable for various patients, dissolving in seconds to a minute.
Rapidly Disintegrating Tablets: Liquefy in the mouth; convenient for those who struggle with swallowing; packaged individually for easy administration.

Preparation Techniques

Lyophilization: Used for preparing certain rapidly disintegrating tablets.
Direct Compression: A dry method of tablet production, compressing powders without modifying their physical characteristics.
Wet Granulation: Involves creating a damp mass from powder mixtures; requires careful binder quantities to ensure tablet integrity.

Formulation Considerations

Diluents: Commonly used excipients include spray-dried lactose and mannitol.
Compression: Greater pressure increases tablet hardness, impacting dissolution and disintegration rates.
Coating: Enteric coatings protect against gastric fluid; materials include shellac, plasticizers, and cellulose derivatives.

Quality Standards

Weight Variation Test: Assesses uniformity by weighing tablets; average weight must meet USP criteria.
Content Uniformity: Requires that each dosage unit's active ingredient falls within 85-115% of the label claim.
Tablet Thickness and Hardness: Affect the tablet's performance and is measured during production; hardness testing ensures durability.

Packaging and Storage

Tablets should be stored in low humidity, tight containers to prevent moisture exposure; desiccants may be included to reduce humidity.
Light-sensitive drugs require protection in opaque containers; specific packaging is crucial for rapidly dissolving tablets due to their softer nature.

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Description

Test your understanding of various pharmaceutical dosage forms, including buccal tablets, sublingual medications, and tablet triturates. This quiz will assess your knowledge of their preparation, characteristics, and rapid drug effects. Perfect for pharmacy students and professionals!

Pharmaceutical Dosage Forms Quiz

Questions and Answers

What is the purpose of using a subcoating on tablets?

Which of the following materials is NOT used in enteric coatings?

Why are tablets packaged in tight containers with desiccant packets?

How do rapidly dissolving tablets differ from regular compressed immediate release tablets?

What is the recommended storage condition for tablets sensitive to light?

What is the primary use of buccal tablets?

What characteristic is true of tablet triturates?

Which ingredient is commonly used as an excipient in chewable tablets?

What is a main reason for the decline in the use of hypodermic tablets?

What is the recommended usage for chewable tablets?

Effervescent tablets are characterized by their ability to:

Which statement is true regarding dispensing tablets?

What is the main characteristic of chewable tablets?

What is the primary factor that affects tablet thickness?

Which of the following systems is known as the fastest disintegrating tablet delivery system?

What pressure range is common for tablet presses during production?

Which characteristic is crucial for tablet hardness that impacts disintegration and dissolution?

Which of the following factors does NOT influence tablet hardness?

What is a common issue associated with rapidly disintegrating tablets?

During quality testing, how long are extended-release tablets simulated in gastric fluid?

What is one potential disadvantage of rapidly disintegrating tablets?

What is the primary purpose of wet granulation in the context of handling powders?

What happens if insufficient binder is used during the wet granulation process?

Which process is characterized by compressing powdered material directly into tablets without modifying its physical nature?

What is the recommended drying temperature for wet granules during the drying process?

What type of agents are included during the mixing of active ingredients and excipients in the direct compression process?

How are the dried granules processed after drying in the wet granulation method?

What is a potential outcome of excessive binder solution in the wet granulation process?

Which component is typically excluded when weighing and mixing for wet granulation?

What is the primary purpose of immediate release tablets?

Rapidly disintegrating or dissolving tablets are specifically intended for which type of patients?

What technique is used in the preparation of rapidly disintegrating/dissolving tablets?

What is a key feature of vaginal tablets/vaginal inserts?

What is the acceptable range for content uniformity according to the USP method?

What is one advantage of rapidly disintegrating/dissolving tablets over traditional oral liquids?

What characterizes rapidly disintegrating or dissolving tablets?

What risk is associated with tablets containing highly potent drug substances?

Study Notes

Tablet Types and Characteristics

Preparation Techniques

Formulation Considerations

Quality Standards

Packaging and Storage

Studying That Suits You

Related Documents

Description

More Quizzes Like This

Pharmaceutical Dosage Forms and Delivery Systems Quiz

Pharmaceutical Dosage Forms Quiz

Solutions Dosage Form: Advantages and Disadvantages of Pharmaceutical...

Pharmaceutical Dosage Forms