Pharmaceutical Dosage Forms Quiz
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Questions and Answers

What is the purpose of using a subcoating on tablets?

  • To improve the dissolution rate in gastric fluid
  • To bond the sugar coating to the tablet and provide rounding (correct)
  • To increase the shelf life of the tablet
  • To enhance flavor and appearance

    • Which of the following materials is NOT used in enteric coatings?

  • Hydroxypropyl methylcellulose phthalate
  • Cellulose acetate phthalate
  • Shellac
  • Gelatin (correct)

    • Why are tablets packaged in tight containers with desiccant packets?

  • To avoid spoilage from moisture (correct)
  • To enhance the release of the active ingredient
  • To minimize the exposure to temperature changes
  • To protect against contamination from air

    • How do rapidly dissolving tablets differ from regular compressed immediate release tablets?

    <p>They tend to be softer and require special packaging</p> Signup and view all the answers

    What is the recommended storage condition for tablets sensitive to light?

    <p>In light-proof containers</p> Signup and view all the answers

    What is the primary use of buccal tablets?

    <p>To dissolve slowly for sustained drug release</p> Signup and view all the answers

    What characteristic is true of tablet triturates?

    <p>They must dissolve completely in water</p> Signup and view all the answers

    Which ingredient is commonly used as an excipient in chewable tablets?

    <p>Mannitol</p> Signup and view all the answers

    What is a main reason for the decline in the use of hypodermic tablets?

    <p>Difficulty in achieving sterility</p> Signup and view all the answers

    What is the recommended usage for chewable tablets?

    <p>To chew thoroughly before swallowing</p> Signup and view all the answers

    Effervescent tablets are characterized by their ability to:

    <p>Release gas upon contact with water</p> Signup and view all the answers

    Which statement is true regarding dispensing tablets?

    <p>Pharmacists use them to compound prescriptions</p> Signup and view all the answers

    What is the main characteristic of chewable tablets?

    <p>They disintegrate and dissolve quickly in the mouth</p> Signup and view all the answers

    What is the primary factor that affects tablet thickness?

    <p>The diameter of the die</p> Signup and view all the answers

    Which of the following systems is known as the fastest disintegrating tablet delivery system?

    <p>Zydis system</p> Signup and view all the answers

    What pressure range is common for tablet presses during production?

    <p>3,000 to 40,000 lb</p> Signup and view all the answers

    Which characteristic is crucial for tablet hardness that impacts disintegration and dissolution?

    <p>Force applied during compression</p> Signup and view all the answers

    Which of the following factors does NOT influence tablet hardness?

    <p>Tablet thickness measurement technique</p> Signup and view all the answers

    What is a common issue associated with rapidly disintegrating tablets?

    <p>Increased drug loading difficulties</p> Signup and view all the answers

    During quality testing, how long are extended-release tablets simulated in gastric fluid?

    <p>1 hour</p> Signup and view all the answers

    What is one potential disadvantage of rapidly disintegrating tablets?

    <p>Reduced stability of the product</p> Signup and view all the answers

    What is the primary purpose of wet granulation in the context of handling powders?

    <p>To form compact masses and reduce toxic dust generation</p> Signup and view all the answers

    What happens if insufficient binder is used during the wet granulation process?

    <p>The adhesion of the granules will be poor</p> Signup and view all the answers

    Which process is characterized by compressing powdered material directly into tablets without modifying its physical nature?

    <p>Direct compression</p> Signup and view all the answers

    What is the recommended drying temperature for wet granules during the drying process?

    <p>60°C</p> Signup and view all the answers

    What type of agents are included during the mixing of active ingredients and excipients in the direct compression process?

    <p>Active ingredients, excipients, lubricants, and glidants</p> Signup and view all the answers

    How are the dried granules processed after drying in the wet granulation method?

    <p>They are passed through Sieve 20 for uniformity</p> Signup and view all the answers

    What is a potential outcome of excessive binder solution in the wet granulation process?

    <p>Hard tablets with slower disintegration rate</p> Signup and view all the answers

    Which component is typically excluded when weighing and mixing for wet granulation?

    <p>Lubricants</p> Signup and view all the answers

    What is the primary purpose of immediate release tablets?

    <p>To disintegrate and release medication without special controls.</p> Signup and view all the answers

    Rapidly disintegrating or dissolving tablets are specifically intended for which type of patients?

    <p>Patients who have difficulty swallowing traditional tablets.</p> Signup and view all the answers

    What technique is used in the preparation of rapidly disintegrating/dissolving tablets?

    <p>Soft direct compression and lyophilization.</p> Signup and view all the answers

    What is a key feature of vaginal tablets/vaginal inserts?

    <p>They are shaped to snugly fit inserter devices.</p> Signup and view all the answers

    What is the acceptable range for content uniformity according to the USP method?

    <p>85% to 115% of the label claim.</p> Signup and view all the answers

    What is one advantage of rapidly disintegrating/dissolving tablets over traditional oral liquids?

    <p>They are more convenient to carry and administer.</p> Signup and view all the answers

    What characterizes rapidly disintegrating or dissolving tablets?

    <p>They liquefy on the tongue within a short time.</p> Signup and view all the answers

    What risk is associated with tablets containing highly potent drug substances?

    <p>They can lead to inaccurate dosing when compounded.</p> Signup and view all the answers

    Study Notes

    Tablet Types and Characteristics

    • Buccal Tablets: Designed for slow erosion; used for sublingual applications like nitroglycerin.
    • Sublingual Tablets: Must dissolve quickly for rapid drug effect; tablet triturates require minimal pressure during manufacture and are soluble in water.
    • Chewable Tablets: Provide smooth disintegration when chewed; typically flavored and colored with mannitol; aids administration for those with swallowing difficulties.
    • Hypodermic Tablets: Used for extemporaneous preparation of injectable solutions but less common now due to the availability of sterile products.
    • Effervescent Tablets: Contain granular salts that release gas when mixed with water, assisting in drug dissolution.
    • Immediate Release Tablets: Disintegrate rapidly without special controls; suitable for various patients, dissolving in seconds to a minute.
    • Rapidly Disintegrating Tablets: Liquefy in the mouth; convenient for those who struggle with swallowing; packaged individually for easy administration.

    Preparation Techniques

    • Lyophilization: Used for preparing certain rapidly disintegrating tablets.
    • Direct Compression: A dry method of tablet production, compressing powders without modifying their physical characteristics.
    • Wet Granulation: Involves creating a damp mass from powder mixtures; requires careful binder quantities to ensure tablet integrity.

    Formulation Considerations

    • Diluents: Commonly used excipients include spray-dried lactose and mannitol.
    • Compression: Greater pressure increases tablet hardness, impacting dissolution and disintegration rates.
    • Coating: Enteric coatings protect against gastric fluid; materials include shellac, plasticizers, and cellulose derivatives.

    Quality Standards

    • Weight Variation Test: Assesses uniformity by weighing tablets; average weight must meet USP criteria.
    • Content Uniformity: Requires that each dosage unit's active ingredient falls within 85-115% of the label claim.
    • Tablet Thickness and Hardness: Affect the tablet's performance and is measured during production; hardness testing ensures durability.

    Packaging and Storage

    • Tablets should be stored in low humidity, tight containers to prevent moisture exposure; desiccants may be included to reduce humidity.
    • Light-sensitive drugs require protection in opaque containers; specific packaging is crucial for rapidly dissolving tablets due to their softer nature.

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    Related Documents

    Tablets PDF

    Description

    Test your understanding of various pharmaceutical dosage forms, including buccal tablets, sublingual medications, and tablet triturates. This quiz will assess your knowledge of their preparation, characteristics, and rapid drug effects. Perfect for pharmacy students and professionals!

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