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Pharmaceutical Chemistry Overview and Benefits of Synthesized Agents Quiz
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Pharmaceutical Chemistry Overview and Benefits of Synthesized Agents Quiz

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Questions and Answers

What is the main advantage of newly synthesized and modified agents over natural ones?

  • Increased toxicity
  • Enhanced biological activity (correct)
  • Poor physicochemical properties
  • Reduced cost
  • Which compound requires further optimization for enhanced therapeutic effect and safety?

  • Hit compound
  • Natural compound
  • Drug compound
  • Lead compound (correct)
  • Which condition is critical for optimal molecular recognition between a drug and its receptor?

  • Low selectivity of the receptor
  • Similar chemical structure
  • Specific binding interactions (correct)
  • High toxicity of the drug
  • What does a receptor (target) do in biological systems?

    <p>Transduces signals</p> Signup and view all the answers

    What differentiates a drug from food and substances providing nutritional support?

    <p>Physiological changes caused when consumed</p> Signup and view all the answers

    Which advantage is NOT associated with newly synthesized and modified agents over natural ones?

    <p>Increased toxicity</p> Signup and view all the answers

    What is the result of achieving the optimal conformational characteristics of a drug and establishing physical forces with its receptor?

    <p>Formation of a stable ligand-receptor complex</p> Signup and view all the answers

    In the context of ligand-receptor recognition, what distinguishes the Key and Lock Theory from the Induced Fit Theory?

    <p>In Key and Lock Theory, both ligand and protein are rigid; in Induced Fit Theory, they are flexible.</p> Signup and view all the answers

    How does the flexibility of a ligand's structure relate to its constituent bond types?

    <p>Single bonds exhibit greater rotational characteristics.</p> Signup and view all the answers

    Why is the formation of covalent bonds not preferred within the ligand-receptor complex?

    <p>Covalent bonds are irreversible.</p> Signup and view all the answers

    What defines ionic interactions within the ligand-receptor complex as preferred?

    <p>They include full positive and full negative charges that attract.</p> Signup and view all the answers

    How would you characterize the π-cationic interaction in a ligand-receptor complex?

    <p>Interaction between positive charges and aromatic centers</p> Signup and view all the answers

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