Podcast
Questions and Answers
What is the main advantage of newly synthesized and modified agents over natural ones?
What is the main advantage of newly synthesized and modified agents over natural ones?
- Increased toxicity
- Enhanced biological activity (correct)
- Poor physicochemical properties
- Reduced cost
Which compound requires further optimization for enhanced therapeutic effect and safety?
Which compound requires further optimization for enhanced therapeutic effect and safety?
- Hit compound
- Natural compound
- Drug compound
- Lead compound (correct)
Which condition is critical for optimal molecular recognition between a drug and its receptor?
Which condition is critical for optimal molecular recognition between a drug and its receptor?
- Low selectivity of the receptor
- Similar chemical structure
- Specific binding interactions (correct)
- High toxicity of the drug
What does a receptor (target) do in biological systems?
What does a receptor (target) do in biological systems?
What differentiates a drug from food and substances providing nutritional support?
What differentiates a drug from food and substances providing nutritional support?
Which advantage is NOT associated with newly synthesized and modified agents over natural ones?
Which advantage is NOT associated with newly synthesized and modified agents over natural ones?
What is the result of achieving the optimal conformational characteristics of a drug and establishing physical forces with its receptor?
What is the result of achieving the optimal conformational characteristics of a drug and establishing physical forces with its receptor?
In the context of ligand-receptor recognition, what distinguishes the Key and Lock Theory from the Induced Fit Theory?
In the context of ligand-receptor recognition, what distinguishes the Key and Lock Theory from the Induced Fit Theory?
How does the flexibility of a ligand's structure relate to its constituent bond types?
How does the flexibility of a ligand's structure relate to its constituent bond types?
Why is the formation of covalent bonds not preferred within the ligand-receptor complex?
Why is the formation of covalent bonds not preferred within the ligand-receptor complex?
What defines ionic interactions within the ligand-receptor complex as preferred?
What defines ionic interactions within the ligand-receptor complex as preferred?
How would you characterize the π-cationic interaction in a ligand-receptor complex?
How would you characterize the π-cationic interaction in a ligand-receptor complex?
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