40 Questions
What is the code of the Medicinal Chemistry 2 course?
PMC 4103
Which of the following is NOT a topic covered in the Medicinal Chemistry 2 course?
Cardiovascular drugs
What is the Domain 1 learning outcome of the Medicinal Chemistry 2 course?
To determine various pharmacophores of some drugs which are responsible for their activities
What is the primary focus of the Domain 3 learning outcomes of the Medicinal Chemistry 2 course?
Correlating the structure of drugs to suitable methods of analysis
Which of the following learning outcomes is NOT a part of the Domain 2 learning outcomes of the Medicinal Chemistry 2 course?
Distinguish the pharmacological activity according to the chemical structure of pharmaceutical drugs
What is the focus of the Domain 4 learning outcomes of the Medicinal Chemistry 2 course?
Personal practice
Which of the following is a topic covered in the Medicinal Chemistry 2 course?
Neurodegenerative diseases
What is the primary focus of the Domain 2 learning outcomes of the Medicinal Chemistry 2 course?
Professional and ethical practice
What is the role of glutamate receptors in the CNS?
They cause alertness and consciousness
What is the effect of Ketamine on NMDA receptors?
It blocks NMDA receptors
What is the effect of GABA on the neuron?
It causes hyper-polarization of the neuron
What is the MAC of an anesthetic?
The concentration that results in the immobility of 50% of patients
What is the effect of age on MAC?
MAC decreases with age
What type of anesthetic is cyclopropane?
Non-halogenated hydrocarbon
What is the defining characteristic of CNS depressants?
They decrease the activity of the central nervous system
What is the advantage of combination anesthesia?
It broadens the therapeutic range
What is the advantage of intravenous anesthetics?
They are psychologically well tolerated
What is the primary effect of general anaesthetics?
Reversible loss of consciousness
What stage of general anesthesia is characterized by loss of consciousness and regular respiration?
Stage of surgical anesthesia
What is the cause of the loss of consciousness in general anesthesia?
Blocking of NMDA and glutamate controlled channels
What is the characteristic of stage IV of general anesthesia?
Loss of consciousness and no spontaneous respiration
What is the effect of general anaesthetics on skeletal muscle tone?
Progressive decrease in skeletal muscle tone
What is the characteristic of anterograde amnesia?
Inability to form new memories
What is the classification of CNS depressants that also have skeletal muscle relaxant properties?
CNS depressants with skeletal muscle relaxant properties
What is the relationship between anesthetic potency and solubility in olive oil?
There is a positive correlation between anesthetic potency and solubility in olive oil.
What is the effect of halogenation on anesthetic potency?
It increases anesthetic potency.
What is the characteristic of the cycloalkanes in terms of anesthetic potency?
They are more potent anesthetics than the straight chain analog with the same number of carbons.
What is the effect of fully saturating an alkane with fluorine in the n-alkane series?
It abolishes anesthetic potency except when n equals one.
What is the reason for the rapid induction of and recovery from anesthesia with halothane?
The presence of three fluorine atoms.
What is the metabolite of halothane that is electrophilic and can form covalent bonds with proteins?
Trifluoroacetyl chloride.
What is the characteristic of intravenous anesthetics?
They produce rapid loss of consciousness but insufficient anesthesia.
What is the reason for the limited use of intravenous anesthetics as single agents?
They produce rapid loss of consciousness but insufficient anesthesia.
What is the primary mechanism by which propofol acts in the CNS?
By enhancing the GABA-ergic neurotransmission
Which of the following is a characteristic of ketamine?
It produces anesthesia by blocking the NMDA controlled channels
What is the effect of N-methylation on methohexital sodium?
It decreases the duration of action
What is the reason for the shorter duration of action of propofol compared to ketamine?
Faster redistribution of propofol from the brain into other tissues
What is the effect of long side chain substitution at position-5 of ultrashort-acting barbiturates?
It increases the lipid solubility
What is the primary mechanism of metabolism of ketamine in the liver?
Reduction to norketamine
What is the effect of the presence of sulfur in thiopental sodium?
It increases the lipid solubility
What is the primary use of ultrashort-acting barbiturates?
To produce rapid unconsciousness for surgical and basal anesthesia
This quiz covers topics in Pharmaceutical Chemistry, including CNS depressants, stimulants, neurodegenerative diseases, endocrine related drugs, and more, for PharmD students.
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