Pharmaceutical Chemistry: Medicinal Chemistry 2

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What is the code of the Medicinal Chemistry 2 course?

PMC 4104

PMC 4102

PMC 4101

PMC 4103 (correct)

Which of the following is NOT a topic covered in the Medicinal Chemistry 2 course?

Cardiovascular drugs (correct)

H2 Blockers

Rheumatoid drugs

NSAIDs

What is the Domain 1 learning outcome of the Medicinal Chemistry 2 course?

To manage and organize time in analyzing drugs

To examine some drugs in various pharmaceutical preparations by chemical tests

To implement good presentation skills

To determine various pharmacophores of some drugs which are responsible for their activities (correct)

What is the primary focus of the Domain 3 learning outcomes of the Medicinal Chemistry 2 course?

Correlating the structure of drugs to suitable methods of analysis Signup and view all the answers

Which of the following learning outcomes is NOT a part of the Domain 2 learning outcomes of the Medicinal Chemistry 2 course?

Distinguish the pharmacological activity according to the chemical structure of pharmaceutical drugs Signup and view all the answers

What is the focus of the Domain 4 learning outcomes of the Medicinal Chemistry 2 course?

Personal practice Signup and view all the answers

Which of the following is a topic covered in the Medicinal Chemistry 2 course?

Neurodegenerative diseases Signup and view all the answers

What is the primary focus of the Domain 2 learning outcomes of the Medicinal Chemistry 2 course?

Professional and ethical practice Signup and view all the answers

What is the role of glutamate receptors in the CNS?

They cause alertness and consciousness Signup and view all the answers

What is the effect of Ketamine on NMDA receptors?

It blocks NMDA receptors Signup and view all the answers

What is the effect of GABA on the neuron?

It causes hyper-polarization of the neuron Signup and view all the answers

What is the MAC of an anesthetic?

The concentration that results in the immobility of 50% of patients Signup and view all the answers

What is the effect of age on MAC?

MAC decreases with age Signup and view all the answers

What type of anesthetic is cyclopropane?

Non-halogenated hydrocarbon Signup and view all the answers

What is the defining characteristic of CNS depressants?

They decrease the activity of the central nervous system Signup and view all the answers

What is the advantage of combination anesthesia?

It broadens the therapeutic range Signup and view all the answers

What is the advantage of intravenous anesthetics?

They are psychologically well tolerated Signup and view all the answers

What is the primary effect of general anaesthetics?

Reversible loss of consciousness Signup and view all the answers

What stage of general anesthesia is characterized by loss of consciousness and regular respiration?

Stage of surgical anesthesia Signup and view all the answers

What is the cause of the loss of consciousness in general anesthesia?

Blocking of NMDA and glutamate controlled channels Signup and view all the answers

What is the characteristic of stage IV of general anesthesia?

Loss of consciousness and no spontaneous respiration Signup and view all the answers

What is the effect of general anaesthetics on skeletal muscle tone?

Progressive decrease in skeletal muscle tone Signup and view all the answers

What is the characteristic of anterograde amnesia?

Inability to form new memories Signup and view all the answers

What is the classification of CNS depressants that also have skeletal muscle relaxant properties?

CNS depressants with skeletal muscle relaxant properties Signup and view all the answers

What is the relationship between anesthetic potency and solubility in olive oil?

There is a positive correlation between anesthetic potency and solubility in olive oil. Signup and view all the answers

What is the effect of halogenation on anesthetic potency?

It increases anesthetic potency. Signup and view all the answers

What is the characteristic of the cycloalkanes in terms of anesthetic potency?

They are more potent anesthetics than the straight chain analog with the same number of carbons. Signup and view all the answers

What is the effect of fully saturating an alkane with fluorine in the n-alkane series?

It abolishes anesthetic potency except when n equals one. Signup and view all the answers

What is the reason for the rapid induction of and recovery from anesthesia with halothane?

The presence of three fluorine atoms. Signup and view all the answers

What is the metabolite of halothane that is electrophilic and can form covalent bonds with proteins?

Trifluoroacetyl chloride. Signup and view all the answers

What is the characteristic of intravenous anesthetics?

They produce rapid loss of consciousness but insufficient anesthesia. Signup and view all the answers

What is the reason for the limited use of intravenous anesthetics as single agents?

They produce rapid loss of consciousness but insufficient anesthesia. Signup and view all the answers

What is the primary mechanism by which propofol acts in the CNS?

By enhancing the GABA-ergic neurotransmission Signup and view all the answers

Which of the following is a characteristic of ketamine?

It produces anesthesia by blocking the NMDA controlled channels Signup and view all the answers

What is the effect of N-methylation on methohexital sodium?

It decreases the duration of action Signup and view all the answers

What is the reason for the shorter duration of action of propofol compared to ketamine?

Faster redistribution of propofol from the brain into other tissues Signup and view all the answers

What is the effect of long side chain substitution at position-5 of ultrashort-acting barbiturates?

It increases the lipid solubility Signup and view all the answers

What is the primary mechanism of metabolism of ketamine in the liver?

Reduction to norketamine Signup and view all the answers

What is the effect of the presence of sulfur in thiopental sodium?