Pharmaceutical Chemistry: Medicinal Chemistry 2
40 Questions
1 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the code of the Medicinal Chemistry 2 course?

  • PMC 4104
  • PMC 4102
  • PMC 4101
  • PMC 4103 (correct)

Which of the following is NOT a topic covered in the Medicinal Chemistry 2 course?

  • Cardiovascular drugs (correct)
  • H2 Blockers
  • Rheumatoid drugs
  • NSAIDs

What is the Domain 1 learning outcome of the Medicinal Chemistry 2 course?

  • To manage and organize time in analyzing drugs
  • To examine some drugs in various pharmaceutical preparations by chemical tests
  • To implement good presentation skills
  • To determine various pharmacophores of some drugs which are responsible for their activities (correct)

What is the primary focus of the Domain 3 learning outcomes of the Medicinal Chemistry 2 course?

<p>Correlating the structure of drugs to suitable methods of analysis (A)</p> Signup and view all the answers

Which of the following learning outcomes is NOT a part of the Domain 2 learning outcomes of the Medicinal Chemistry 2 course?

<p>Distinguish the pharmacological activity according to the chemical structure of pharmaceutical drugs (C)</p> Signup and view all the answers

What is the focus of the Domain 4 learning outcomes of the Medicinal Chemistry 2 course?

<p>Personal practice (D)</p> Signup and view all the answers

Which of the following is a topic covered in the Medicinal Chemistry 2 course?

<p>Neurodegenerative diseases (D)</p> Signup and view all the answers

What is the primary focus of the Domain 2 learning outcomes of the Medicinal Chemistry 2 course?

<p>Professional and ethical practice (A)</p> Signup and view all the answers

What is the role of glutamate receptors in the CNS?

<p>They cause alertness and consciousness (A)</p> Signup and view all the answers

What is the effect of Ketamine on NMDA receptors?

<p>It blocks NMDA receptors (D)</p> Signup and view all the answers

What is the effect of GABA on the neuron?

<p>It causes hyper-polarization of the neuron (B)</p> Signup and view all the answers

What is the MAC of an anesthetic?

<p>The concentration that results in the immobility of 50% of patients (A)</p> Signup and view all the answers

What is the effect of age on MAC?

<p>MAC decreases with age (B)</p> Signup and view all the answers

What type of anesthetic is cyclopropane?

<p>Non-halogenated hydrocarbon (A)</p> Signup and view all the answers

What is the defining characteristic of CNS depressants?

<p>They decrease the activity of the central nervous system (B)</p> Signup and view all the answers

What is the advantage of combination anesthesia?

<p>It broadens the therapeutic range (D)</p> Signup and view all the answers

What is the advantage of intravenous anesthetics?

<p>They are psychologically well tolerated (A)</p> Signup and view all the answers

What is the primary effect of general anaesthetics?

<p>Reversible loss of consciousness (A)</p> Signup and view all the answers

What stage of general anesthesia is characterized by loss of consciousness and regular respiration?

<p>Stage of surgical anesthesia (D)</p> Signup and view all the answers

What is the cause of the loss of consciousness in general anesthesia?

<p>Blocking of NMDA and glutamate controlled channels (C)</p> Signup and view all the answers

What is the characteristic of stage IV of general anesthesia?

<p>Loss of consciousness and no spontaneous respiration (B)</p> Signup and view all the answers

What is the effect of general anaesthetics on skeletal muscle tone?

<p>Progressive decrease in skeletal muscle tone (C)</p> Signup and view all the answers

What is the characteristic of anterograde amnesia?

<p>Inability to form new memories (B)</p> Signup and view all the answers

What is the classification of CNS depressants that also have skeletal muscle relaxant properties?

<p>CNS depressants with skeletal muscle relaxant properties (A)</p> Signup and view all the answers

What is the relationship between anesthetic potency and solubility in olive oil?

<p>There is a positive correlation between anesthetic potency and solubility in olive oil. (D)</p> Signup and view all the answers

What is the effect of halogenation on anesthetic potency?

<p>It increases anesthetic potency. (C)</p> Signup and view all the answers

What is the characteristic of the cycloalkanes in terms of anesthetic potency?

<p>They are more potent anesthetics than the straight chain analog with the same number of carbons. (A)</p> Signup and view all the answers

What is the effect of fully saturating an alkane with fluorine in the n-alkane series?

<p>It abolishes anesthetic potency except when n equals one. (B)</p> Signup and view all the answers

What is the reason for the rapid induction of and recovery from anesthesia with halothane?

<p>The presence of three fluorine atoms. (D)</p> Signup and view all the answers

What is the metabolite of halothane that is electrophilic and can form covalent bonds with proteins?

<p>Trifluoroacetyl chloride. (D)</p> Signup and view all the answers

What is the characteristic of intravenous anesthetics?

<p>They produce rapid loss of consciousness but insufficient anesthesia. (A)</p> Signup and view all the answers

What is the reason for the limited use of intravenous anesthetics as single agents?

<p>They produce rapid loss of consciousness but insufficient anesthesia. (A)</p> Signup and view all the answers

What is the primary mechanism by which propofol acts in the CNS?

<p>By enhancing the GABA-ergic neurotransmission (B)</p> Signup and view all the answers

Which of the following is a characteristic of ketamine?

<p>It produces anesthesia by blocking the NMDA controlled channels (A)</p> Signup and view all the answers

What is the effect of N-methylation on methohexital sodium?

<p>It decreases the duration of action (A)</p> Signup and view all the answers

What is the reason for the shorter duration of action of propofol compared to ketamine?

<p>Faster redistribution of propofol from the brain into other tissues (A)</p> Signup and view all the answers

What is the effect of long side chain substitution at position-5 of ultrashort-acting barbiturates?

<p>It increases the lipid solubility (B)</p> Signup and view all the answers

What is the primary mechanism of metabolism of ketamine in the liver?

<p>Reduction to norketamine (C)</p> Signup and view all the answers

What is the effect of the presence of sulfur in thiopental sodium?

<p>It increases the lipid solubility (A)</p> Signup and view all the answers

What is the primary use of ultrashort-acting barbiturates?

<p>To produce rapid unconsciousness for surgical and basal anesthesia (C)</p> Signup and view all the answers

More Like This

Use Quizgecko on...
Browser
Browser