Pharmaceutical Chemistry Learning Objectives

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Which factor is NOT considered when designing chemical isosteres?

Hydrogen bonding

Molecular weight

Charge

Size (correct)

What purpose can the isosteric replacement of functional groups serve?

Reduce duration of action

Enhance side effects

Decrease specificity

Increase potency (correct)

Which compound is mentioned as an example of bioisosteres in the text?

Procainamide (correct)

Alloxanthine

Procaine

Xanthine

What effect does isosteric replacement have on the duration of action of a compound?

Prolong duration of action Signup and view all the answers

Which compound acts as an inhibitor of xanthine oxidase and is an isostere of xanthine?

Alloxanthine Signup and view all the answers

How does alloxanthine act in relation to xanthine according to the text?

Antagonistically Signup and view all the answers

What is the main focus of Pharmaceutical Chemistry?

Developing new drug formulations Signup and view all the answers

What does the term 'Structure-Activity Relationship' refer to in Pharmaceutical Chemistry?

The relationship between molecular structure and biological activity Signup and view all the answers

Which functional group in drugs plays a role in muscle relaxant activity?

Tertiary amine groups Signup and view all the answers

What is the key aspect to consider in pharmaceutical applications related to stereochemistry?

Biological activity differences between enantiomers Signup and view all the answers

Which concept focuses on the relationship between molecular structure and biological activity of drugs?

Structure-Activity Relationship Signup and view all the answers

In Pharmaceutical Chemistry, what does the term 'Epimers' refer to?

Stereoisomers that differ at one chiral center Signup and view all the answers

What does the Partition Coefficient (P) in Pharmaceutical Chemistry represent?

The ratio of solubility in an organic solvent to solubility in an aqueous environment Signup and view all the answers

What is the main characteristic of Inorganic salts in pharmaceutical applications?

Increased water solubility compared to the parent molecule Signup and view all the answers

Which rule is also known as Pfizer’s Rule of Five and is used to evaluate drug-likeness?

E.Lipinski’s Rule of Five Signup and view all the answers

In what form are Organic salts made in pharmaceutical chemistry?

By combining two drug molecules, one acidic and one basic Signup and view all the answers

What is the purpose of using Inorganic salts in pharmaceutical formulations?

To improve oral bioavailability Signup and view all the answers

Which class of salts has increased lipid solubility and is generally used for depot injections?

Organic salts Signup and view all the answers