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Questions and Answers
What is jaundice and what causes its characteristic yellowish appearance?
What is jaundice and what causes its characteristic yellowish appearance?
Jaundice is caused by excess bilirubin in the bloodstream, which dissolves in subcutaneous fat, leading to a yellowish appearance of the skin and the whites of the eyes.
Define acidosis and alkalosis in the context of human physiological pH.
Define acidosis and alkalosis in the context of human physiological pH.
Acidosis occurs when the physiological pH falls below 7.35, while alkalosis occurs when it exceeds 7.45.
What is phenylketonuria (PKU) and what is its effect on the body?
What is phenylketonuria (PKU) and what is its effect on the body?
Phenylketonuria (PKU) is an inherited disorder that leads to elevated levels of phenylalanine in the blood, which can cause brain damage if untreated.
Explain how enzymes function as biological catalysts in biochemical reactions.
Explain how enzymes function as biological catalysts in biochemical reactions.
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Differentiate between anabolic and catabolic processes.
Differentiate between anabolic and catabolic processes.
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What are lysosomal storage diseases and how do they affect the body?
What are lysosomal storage diseases and how do they affect the body?
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What is atherosclerosis, and what causes this condition?
What is atherosclerosis, and what causes this condition?
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Describe dental fluorosis and its cause.
Describe dental fluorosis and its cause.
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What happens to glucose during oxidation in cellular respiration?
What happens to glucose during oxidation in cellular respiration?
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Identify the role of NAD+ in glycolysis.
Identify the role of NAD+ in glycolysis.
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What is the overall chemical equation for the oxidation of glucose?
What is the overall chemical equation for the oxidation of glucose?
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How are redox reactions essential for basic life functions?
How are redox reactions essential for basic life functions?
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What is the oxidizing agent in the oxidation of glucose?
What is the oxidizing agent in the oxidation of glucose?
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What is the significance of glycolysis in cellular respiration?
What is the significance of glycolysis in cellular respiration?
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Explain the difference between anabolic and catabolic reactions.
Explain the difference between anabolic and catabolic reactions.
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Describe the role of ATP in cellular processes.
Describe the role of ATP in cellular processes.
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What products are generated from the glycolysis of one molecule of glucose?
What products are generated from the glycolysis of one molecule of glucose?
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What is hydrolysis and how does it function in breaking down polymers?
What is hydrolysis and how does it function in breaking down polymers?
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What are exothermic reactions, and why are they important in metabolic processes?
What are exothermic reactions, and why are they important in metabolic processes?
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How does the respiratory route connect anabolic and catabolic processes?
How does the respiratory route connect anabolic and catabolic processes?
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Provide an example of a synthesis reaction and explain its significance.
Provide an example of a synthesis reaction and explain its significance.
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What is the primary focus of pharmaceutical biochemistry?
What is the primary focus of pharmaceutical biochemistry?
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Describe the significance of glycolysis in living organisms.
Describe the significance of glycolysis in living organisms.
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What are the four main classes of biomolecules studied in biochemistry?
What are the four main classes of biomolecules studied in biochemistry?
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Explain the role of enzymes in biochemical reactions.
Explain the role of enzymes in biochemical reactions.
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What is meant by the term 'macromolecules' in the context of cellular structure?
What is meant by the term 'macromolecules' in the context of cellular structure?
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Discuss the importance of biochemical pathways in living organisms.
Discuss the importance of biochemical pathways in living organisms.
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How does pharmaceutical biochemistry contribute to disease management?
How does pharmaceutical biochemistry contribute to disease management?
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What are the primary components of a cell as described in the context of biochemistry?
What are the primary components of a cell as described in the context of biochemistry?
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What is the significance of therapeutic drug monitoring in patient care?
What is the significance of therapeutic drug monitoring in patient care?
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How do biomarkers play a role in disease diagnosis?
How do biomarkers play a role in disease diagnosis?
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Explain the importance of monitoring blood glucose levels.
Explain the importance of monitoring blood glucose levels.
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What roles do enzymes such as creatine kinase and lactate dehydrogenase serve in biochemistry?
What roles do enzymes such as creatine kinase and lactate dehydrogenase serve in biochemistry?
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Describe the function of carbohydrates and lipids in the human body.
Describe the function of carbohydrates and lipids in the human body.
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How do vitamins contribute to human health?
How do vitamins contribute to human health?
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What is the relationship between molecular genetics and heredity?
What is the relationship between molecular genetics and heredity?
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Why is enzyme activity crucial for chemical processes in the human body?
Why is enzyme activity crucial for chemical processes in the human body?
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Study Notes
Course Title and Description
- Course title: Pharmaceutical Chemistry-IIA (Biochemistry)
- The course will cover pharmaceutical biochemistry and its role in the health profession.
- The course will also cover the nature of biochemical reactions.
Course Contents
- General Introduction and Basic Biochemical Principles: Pharmaceutical biochemistry in the health profession and the nature of biochemical reactions.
- Basic Chemistry of Biomolecules: Carbohydrates, proteins and amino acids, lipids, nucleic acid, vitamins, hormones, and enzymes.
Examination Pattern
- Midterm exams
- Final exams
- Class presentations (CP), including assignments, quizzes, and presentations
What is Biochemistry?
- Combination of chemistry and biology
- Investigation of the chemistry (biochemical processes) of living systems
- Application of chemistry to the study of biological processes at the cellular/molecular level
- Study of the structure and behavior of complex molecules
- Understanding of how these molecules combine to form organisms
Basic Concepts
- A cell is made of molecules, and a molecule is made of atoms.
- Cells are highly organized with various chemical pathways
- All living organisms use similar types of molecules including carbohydrates, proteins, lipids, and nucleic acids
- Precise regulation and integration of pathways are crucial for life
Pharmaceutical Biochemistry
- Studies how molecules in the body interact with drugs
- Investigates the nature of binding between drugs and receptors and drug action at the cellular level
- Essential for improving human health, treatment and prevention of diseases
Role of Pharmaceutical Biochemistry in Health Profession
- Chemical components of the human body, including carbohydrates, lipids, amino acids, proteins, blood, plasma, biological membranes, DNA, and RNA
- Major chemical processes in the body, including cell development, enzyme activity, membrane transport, homeostasis, blood coagulation, oxygen transport, neurotransmitter function, aging, nutrition, and mineral metabolism.
- Role of vitamins in the body
- Molecular genetics, heredity, genomics
Therapeutic Drug Monitoring
- Biochemistry provides valuable information for diagnosis, monitoring, and treatment of diseases
- Measurement of drug concentrations in the blood to ensure patients receive the correct dosage
- Crucial for drugs with a narrow therapeutic window (too little or too much can be harmful)
- Adjusting dosages for appropriate treatment
Biochemical Markers
- Substances in the body that indicate the presence of a disease or condition.
- Measured in blood, urine, or other bodily fluids
- Examples include: blood glucose, cholesterol, enzymes (creatine kinase, lactate dehydrogenase), and electrolytes (sodium, potassium).
Diseases and Their Molecular Basis
- All diseases have a molecular basis
- Enables understanding of chemical processes involved in conditions
- Diseases mentioned: diabetes, hyperammonemia, hypo/hyperparathyroidism, jaundice, kidney dysfunction, hypercholesterolemia, phenylketonuria, sickle cell anaemia, dental fluorosis, rickets, acidosis, alkalosis, lysosomal storage diseases, atherosclerosis.
Specific Disease Descriptions
- Jaundice - condition caused by excess bilirubin in the bloodstream
- Normal human physiological pH - 7.35-7.45; pH below this range is acidosis; above, alkalosis
- Phenylketonuria (PKU) - inherited disorder increasing phenylalanine levels in the blood
- Lysosomal storage diseases (LSDs) - rare genetic disorders due to enzyme deficiency that damage cells and organs
- Atherosclerosis - thickening/hardening of arteries due to plaque buildup
- Dental fluorosis - caused by excessive fluoride intake during tooth formation
- Sickle cell anaemia - severe hereditary form of anaemia where mutated haemoglobin distorts red blood cells in low oxygen
Biochemical Reactions
- Chemical reactions inside cells are biochemical reactions
- Transformation of one molecule into another
- Mediated by enzymes – biological catalysts that alter reaction rates and specificity
Types of Biochemical Reactions
-
Anabolic processes: endergonic reactions where small molecules combine to make larger molecules. Energy is required
- Combining amino acids to make proteins is an example.
-
Catabolic processes: exergonic reactions where larger molecules break down to smaller ones, releasing energy
- Breakdown of glucose to release energy for cell function is an example.
Glycolysis
- Process where glucose breaks down to produce energy (ATP)
- This is essential for cell survival as ATP is the primary energy carrier
- Occurs in the cytoplasm of cells
- Involves the conversion of glucose to molecules of pyruvate, ATP, NADH, and water.
ATP (Adenosine Triphosphate)
- Universal energy carrier found in every cell of living organisms
- Forms from oxidation-reduction, and condensation reactions.
- Breaks down by hydrolysis to release energy for cellular processes
- Converted to ADP and AMP when consumed
Synthesis Reactions
- Combining two or more reactants to form larger molecules.
- Mostly exothermic (release energy as heat)
- Examples include combining amino acids into proteins.
Hydrolysis Reactions
- Breaking down a molecule into smaller units using water.
- Examples include breaking down proteins into amino acids.
Oxidation-Reduction (Redox) Reactions
- Involve the transfer of electrons between molecules.
- Oxidation - loss of electrons
- Reduction - gain of electrons
- Essential for cellular processes, including cellular respiration
- An example includes the oxidation of glucose into carbon dioxide, water, and energy.
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Description
Test your knowledge on pharmaceutical biochemistry and its essential biochemical principles. This quiz will cover the chemistry of biomolecules, including carbohydrates, proteins, and more, highlighting their significance in health professions.