Pharmaceutical Chemistry-IIA Biochemistry Quiz
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Questions and Answers

What is jaundice and what causes its characteristic yellowish appearance?

Jaundice is caused by excess bilirubin in the bloodstream, which dissolves in subcutaneous fat, leading to a yellowish appearance of the skin and the whites of the eyes.

Define acidosis and alkalosis in the context of human physiological pH.

Acidosis occurs when the physiological pH falls below 7.35, while alkalosis occurs when it exceeds 7.45.

What is phenylketonuria (PKU) and what is its effect on the body?

Phenylketonuria (PKU) is an inherited disorder that leads to elevated levels of phenylalanine in the blood, which can cause brain damage if untreated.

Explain how enzymes function as biological catalysts in biochemical reactions.

<p>Enzymes speed up biochemical reactions by lowering the activation energy required, thus increasing the reaction rate and specificity.</p> Signup and view all the answers

Differentiate between anabolic and catabolic processes.

<p>Anabolic processes involve building up molecules and storing energy, while catabolic processes involve breaking down molecules to release energy.</p> Signup and view all the answers

What are lysosomal storage diseases and how do they affect the body?

<p>Lysosomal storage diseases are genetic disorders caused by enzyme deficiencies that lead to the accumulation of toxic substances in cells, damaging body tissues and organs.</p> Signup and view all the answers

What is atherosclerosis, and what causes this condition?

<p>Atherosclerosis is the thickening or hardening of arteries caused by the buildup of plaque, which consists of fats and cholesterol.</p> Signup and view all the answers

Describe dental fluorosis and its cause.

<p>Dental fluorosis is a condition resulting from excessive fluoride intake during the development of teeth, leading to discoloration and damage.</p> Signup and view all the answers

What happens to glucose during oxidation in cellular respiration?

<p>Glucose loses electrons during oxidation, resulting in its conversion to carbon dioxide and water.</p> Signup and view all the answers

Identify the role of NAD+ in glycolysis.

<p>NAD+ acts as an oxidizing agent by gaining electrons and becoming reduced to NADH.</p> Signup and view all the answers

What is the overall chemical equation for the oxidation of glucose?

<p><code>C6H12O6 + 6O2 → 6CO2 + 6H2O</code></p> Signup and view all the answers

How are redox reactions essential for basic life functions?

<p>Redox reactions are vital for processes like photosynthesis and respiration, facilitating energy transfer and transformation in living organisms.</p> Signup and view all the answers

What is the oxidizing agent in the oxidation of glucose?

<p>Oxygen is the oxidizing agent, gaining electrons during the reaction.</p> Signup and view all the answers

What is the significance of glycolysis in cellular respiration?

<p>Glycolysis is essential as it breaks down glucose to produce ATP, which is necessary for energy in cells.</p> Signup and view all the answers

Explain the difference between anabolic and catabolic reactions.

<p>Anabolic reactions build larger molecules from smaller ones and require energy, while catabolic reactions break down large molecules into smaller ones, releasing energy.</p> Signup and view all the answers

Describe the role of ATP in cellular processes.

<p>ATP serves as the universal energy carrier, providing energy for processes like muscle contraction and chemical synthesis.</p> Signup and view all the answers

What products are generated from the glycolysis of one molecule of glucose?

<p>Glycolysis produces 2 pyruvate molecules, 4 ATP (net gain of 2 ATP), and 2 NADH.</p> Signup and view all the answers

What is hydrolysis and how does it function in breaking down polymers?

<p>Hydrolysis is a chemical reaction that uses water to break down polymers into simpler monomers, such as peptides into amino acids.</p> Signup and view all the answers

What are exothermic reactions, and why are they important in metabolic processes?

<p>Exothermic reactions release energy, making them vital for metabolic processes that utilize energy to fuel cellular activities.</p> Signup and view all the answers

How does the respiratory route connect anabolic and catabolic processes?

<p>The respiratory route is an amphibolic pathway that links the synthesis of biomolecules (anabolic) and the breakdown of substrates for energy (catabolic).</p> Signup and view all the answers

Provide an example of a synthesis reaction and explain its significance.

<p>An example of a synthesis reaction is the formation of protein molecules from amino acids, which is significant for building cellular structures and functions.</p> Signup and view all the answers

What is the primary focus of pharmaceutical biochemistry?

<p>The primary focus of pharmaceutical biochemistry is to study how molecules in the body interact with drugs.</p> Signup and view all the answers

Describe the significance of glycolysis in living organisms.

<p>Glycolysis is a common metabolic pathway found in almost all organisms, highlighting the universality of biochemical processes.</p> Signup and view all the answers

What are the four main classes of biomolecules studied in biochemistry?

<p>The four main classes of biomolecules are carbohydrates, proteins, lipids, and nucleic acids.</p> Signup and view all the answers

Explain the role of enzymes in biochemical reactions.

<p>Enzymes act as catalysts to speed up biochemical reactions, facilitating various metabolic processes within living cells.</p> Signup and view all the answers

What is meant by the term 'macromolecules' in the context of cellular structure?

<p>Macromolecules refer to large, complex molecules such as proteins, lipids, and nucleic acids that make up the structure of cells.</p> Signup and view all the answers

Discuss the importance of biochemical pathways in living organisms.

<p>Biochemical pathways are critical for the regulation and integration of chemical processes that sustain life.</p> Signup and view all the answers

How does pharmaceutical biochemistry contribute to disease management?

<p>Pharmaceutical biochemistry contributes by applying biochemical methods for diagnosing, treating, and preventing diseases.</p> Signup and view all the answers

What are the primary components of a cell as described in the context of biochemistry?

<p>The primary components of a cell include molecules made up of atoms, particularly macromolecules.</p> Signup and view all the answers

What is the significance of therapeutic drug monitoring in patient care?

<p>Therapeutic drug monitoring ensures that patients receive the correct dosage of medications, especially those with a narrow therapeutic index, to avoid toxicity or ineffectiveness.</p> Signup and view all the answers

How do biomarkers play a role in disease diagnosis?

<p>Biomarkers are substances that indicate the presence of a disease and are typically measured in bodily fluids like blood or urine.</p> Signup and view all the answers

Explain the importance of monitoring blood glucose levels.

<p>Monitoring blood glucose levels is crucial for diagnosing and managing diabetes effectively.</p> Signup and view all the answers

What roles do enzymes such as creatine kinase and lactate dehydrogenase serve in biochemistry?

<p>These enzymes are biomarkers used to indicate tissue damage or disease within the body.</p> Signup and view all the answers

Describe the function of carbohydrates and lipids in the human body.

<p>Carbohydrates provide energy, while lipids serve as energy storage and are vital for membrane structure.</p> Signup and view all the answers

How do vitamins contribute to human health?

<p>Vitamins play critical roles in various biochemical processes, including metabolism, immune function, and cell repair.</p> Signup and view all the answers

What is the relationship between molecular genetics and heredity?

<p>Molecular genetics studies how genes are inherited and express traits in organisms.</p> Signup and view all the answers

Why is enzyme activity crucial for chemical processes in the human body?

<p>Enzyme activity is essential for facilitating biochemical reactions that support metabolism, digestion, and other physiological functions.</p> Signup and view all the answers

Study Notes

Course Title and Description

  • Course title: Pharmaceutical Chemistry-IIA (Biochemistry)
  • The course will cover pharmaceutical biochemistry and its role in the health profession.
  • The course will also cover the nature of biochemical reactions.

Course Contents

  • General Introduction and Basic Biochemical Principles: Pharmaceutical biochemistry in the health profession and the nature of biochemical reactions.
  • Basic Chemistry of Biomolecules: Carbohydrates, proteins and amino acids, lipids, nucleic acid, vitamins, hormones, and enzymes.

Examination Pattern

  • Midterm exams
  • Final exams
  • Class presentations (CP), including assignments, quizzes, and presentations

What is Biochemistry?

  • Combination of chemistry and biology
  • Investigation of the chemistry (biochemical processes) of living systems
  • Application of chemistry to the study of biological processes at the cellular/molecular level
  • Study of the structure and behavior of complex molecules
  • Understanding of how these molecules combine to form organisms

Basic Concepts

  • A cell is made of molecules, and a molecule is made of atoms.
  • Cells are highly organized with various chemical pathways
  • All living organisms use similar types of molecules including carbohydrates, proteins, lipids, and nucleic acids
  • Precise regulation and integration of pathways are crucial for life

Pharmaceutical Biochemistry

  • Studies how molecules in the body interact with drugs
  • Investigates the nature of binding between drugs and receptors and drug action at the cellular level
  • Essential for improving human health, treatment and prevention of diseases

Role of Pharmaceutical Biochemistry in Health Profession

  • Chemical components of the human body, including carbohydrates, lipids, amino acids, proteins, blood, plasma, biological membranes, DNA, and RNA
  • Major chemical processes in the body, including cell development, enzyme activity, membrane transport, homeostasis, blood coagulation, oxygen transport, neurotransmitter function, aging, nutrition, and mineral metabolism.
  • Role of vitamins in the body
  • Molecular genetics, heredity, genomics

Therapeutic Drug Monitoring

  • Biochemistry provides valuable information for diagnosis, monitoring, and treatment of diseases
  • Measurement of drug concentrations in the blood to ensure patients receive the correct dosage
  • Crucial for drugs with a narrow therapeutic window (too little or too much can be harmful)
  • Adjusting dosages for appropriate treatment

Biochemical Markers

  • Substances in the body that indicate the presence of a disease or condition.
  • Measured in blood, urine, or other bodily fluids
  • Examples include: blood glucose, cholesterol, enzymes (creatine kinase, lactate dehydrogenase), and electrolytes (sodium, potassium).

Diseases and Their Molecular Basis

  • All diseases have a molecular basis
  • Enables understanding of chemical processes involved in conditions
  • Diseases mentioned: diabetes, hyperammonemia, hypo/hyperparathyroidism, jaundice, kidney dysfunction, hypercholesterolemia, phenylketonuria, sickle cell anaemia, dental fluorosis, rickets, acidosis, alkalosis, lysosomal storage diseases, atherosclerosis.

Specific Disease Descriptions

  • Jaundice - condition caused by excess bilirubin in the bloodstream
  • Normal human physiological pH - 7.35-7.45; pH below this range is acidosis; above, alkalosis
  • Phenylketonuria (PKU) - inherited disorder increasing phenylalanine levels in the blood
  • Lysosomal storage diseases (LSDs) - rare genetic disorders due to enzyme deficiency that damage cells and organs
  • Atherosclerosis - thickening/hardening of arteries due to plaque buildup
  • Dental fluorosis - caused by excessive fluoride intake during tooth formation
  • Sickle cell anaemia - severe hereditary form of anaemia where mutated haemoglobin distorts red blood cells in low oxygen

Biochemical Reactions

  • Chemical reactions inside cells are biochemical reactions
  • Transformation of one molecule into another
  • Mediated by enzymes – biological catalysts that alter reaction rates and specificity

Types of Biochemical Reactions

  • Anabolic processes: endergonic reactions where small molecules combine to make larger molecules. Energy is required
    • Combining amino acids to make proteins is an example.
  • Catabolic processes: exergonic reactions where larger molecules break down to smaller ones, releasing energy
    • Breakdown of glucose to release energy for cell function is an example.

Glycolysis

  • Process where glucose breaks down to produce energy (ATP)
  • This is essential for cell survival as ATP is the primary energy carrier
  • Occurs in the cytoplasm of cells
  • Involves the conversion of glucose to molecules of pyruvate, ATP, NADH, and water.

ATP (Adenosine Triphosphate)

  • Universal energy carrier found in every cell of living organisms
  • Forms from oxidation-reduction, and condensation reactions.
  • Breaks down by hydrolysis to release energy for cellular processes
  • Converted to ADP and AMP when consumed

Synthesis Reactions

  • Combining two or more reactants to form larger molecules.
  • Mostly exothermic (release energy as heat)
  • Examples include combining amino acids into proteins.

Hydrolysis Reactions

  • Breaking down a molecule into smaller units using water.
  • Examples include breaking down proteins into amino acids.

Oxidation-Reduction (Redox) Reactions

  • Involve the transfer of electrons between molecules.
  • Oxidation - loss of electrons
  • Reduction - gain of electrons
  • Essential for cellular processes, including cellular respiration
  • An example includes the oxidation of glucose into carbon dioxide, water, and energy.

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Test your knowledge on pharmaceutical biochemistry and its essential biochemical principles. This quiz will cover the chemistry of biomolecules, including carbohydrates, proteins, and more, highlighting their significance in health professions.

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