Pharmaceutical Aerosols

Definition of Aerosols in Pharmaceutical Manufacturing

• Aerosols are defined as a colloidal dispersion of a liquid or solid in a gas, typically air or nitrogen.
• In the context of pharmaceutical manufacturing, aerosols are used to denote a mixture of active pharmaceutical ingredients (APIs) and propellants in a canister, which is dispensed as a spray.

Components of an Aerosol Package

• An aerosol package consists of a canister, a valve, an actuator, and a product concentrate.
• A common component of an aerosol package is a propellant, which is responsible for dispelling the product from the canister.

Safety Hazards Associated with Pharmaceutical Aerosols

• The primary safety hazard associated with pharmaceutical aerosols is the potential for explosion or rupture due to excessive pressure buildup.
• This hazard is more significant if the aerosol is not stored properly, such as in high temperatures or near open flames.

Shelf Life and Performance of Pharmaceutical Aerosols

• During the shelf life of pharmaceutical aerosols, the performance of the product can deteriorate due to factors such as degradation of the API, corrosion of the container, or changes in the propellant system.
• This can lead to a decrease in the product's efficacy, stability, and overall quality.

Conversion of Topical and Nasal Sprays

• Most topical and nasal sprays can be converted into aerosols, which provides a more convenient and efficient way of delivering the medication.
• This conversion is often preferred due to the improved ease of use and increased patient compliance.