Pharmaceutical Aerosols

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15 Questions

What is an aerosol in pharmaceutical manufacturing?

A dispersion of a solid or a liquid in gaseous phase

What can deteriorate during the shelf life of pharmaceutical aerosols?

Performance

What are aerosols defined as?

Colloidal systems consisting of very finely subdivided liquid or solid particles dispersed in and surrounded by a gas

What is a key safety hazard associated with pharmaceutical aerosols?

Flammability

What are most topical and nasal sprays converted into now?

Water-based pump sprays

What are the components of an aerosol package in pharmaceutical manufacturing?

Propellant, container, valve and actuator, product concentrate

What is the definition of aerosols in the context of pharmaceutical manufacturing?

Colloidal systems consisting of very finely subdivided liquid or solid particles dispersed in and surrounded by a gas

What is the primary safety hazard associated with pharmaceutical aerosols?

Flammable and pressurized

What can most topical and nasal sprays be converted into now?

Water-based pump sprays

What happens to the performance of pharmaceutical aerosols during their shelf life?

Performance can deteriorate

What is the definition of an aerosol in pharmaceutical terms?

A dispersion of a solid or a liquid in gaseous phase

What are aerosols used to denote in pharmaceutical context?

Various systems ranging from colloidal nature to pressurized packages

What is a common component of an aerosol package?

Propellant

What is the potential safety hazard associated with pharmaceutical aerosols?

Flammable and pressurized

What are most topical and nasal sprays converted into now?

Water-based pump sprays

Study Notes

Definition of Aerosols in Pharmaceutical Manufacturing

  • Aerosols are defined as a colloidal dispersion of a liquid or solid in a gas, typically air or nitrogen.
  • In the context of pharmaceutical manufacturing, aerosols are used to denote a mixture of active pharmaceutical ingredients (APIs) and propellants in a canister, which is dispensed as a spray.

Components of an Aerosol Package

  • An aerosol package consists of a canister, a valve, an actuator, and a product concentrate.
  • A common component of an aerosol package is a propellant, which is responsible for dispelling the product from the canister.

Safety Hazards Associated with Pharmaceutical Aerosols

  • The primary safety hazard associated with pharmaceutical aerosols is the potential for explosion or rupture due to excessive pressure buildup.
  • This hazard is more significant if the aerosol is not stored properly, such as in high temperatures or near open flames.

Shelf Life and Performance of Pharmaceutical Aerosols

  • During the shelf life of pharmaceutical aerosols, the performance of the product can deteriorate due to factors such as degradation of the API, corrosion of the container, or changes in the propellant system.
  • This can lead to a decrease in the product's efficacy, stability, and overall quality.

Conversion of Topical and Nasal Sprays

  • Most topical and nasal sprays can be converted into aerosols, which provides a more convenient and efficient way of delivering the medication.
  • This conversion is often preferred due to the improved ease of use and increased patient compliance.

Test your knowledge of pharmaceutical manufacturing with this quiz on Chapter 50: Pharmaceutical Aerosols. Explore the dispersion of solids or liquids in the gaseous phase and learn about the various systems used in pharmaceutical aerosols.

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