38 Questions
What is the most frequently used coronary function imaging test in the UK and worldwide?
Myocardial perfusion scintigraphy (MPS)
What is the goal of this review?
To consider the expanding role of radionuclide imaging in cardiac imaging
What is the outcome of the second phase III trial of the MPS PET tracer?
Ongoing and promising
What is a strength of radionuclide-based techniques in cardiac imaging?
Ability to provide quantification of myocardial perfusion in absolute terms
What is a limitation of MPS PET?
Inability to quantify myocardial perfusion in absolute terms
What is a potential application of radionuclide imaging in cardiac imaging?
Imaging myocardial inflammation or infection
What did the echocardiography and CT scans reveal about the aortic root?
It appeared thickened
What was unclear about the infection?
Whether it was on the valve and/or the ICD
What does the figure show?
An initial FDG PET fused with CT in the coronal plane
What is the function of the ICD?
To regulate heart rhythm
What did the initial FDG PET-CT scan show?
Abnormal activity related to the valve and aortic root
What did the subsequent PET-CT scan show?
Extension of the infection into the soft tissue
What was confirmed on CT to be an abscess?
An abscess in the soft tissue around the left main coronary artery
What cannot be excluded as a possibility?
Myocarditis
What is the potential source of 18F-fluorodeoxyglucose accumulation in arterial atheroma?
Inflammatory macrophages
Why is imaging FDG by PET in small coronary arteries challenging?
Because of the rapid movement of coronary arteries
What is the advantage of using sodium 18F-fluoride and 68Ga-dotatate over FDG?
They do not require dietary manipulation
What is the current direction of National Institute for Health and Care Excellence (NICE) guidance?
Towards anatomical assessment
What is the target of 68Ga-dotatate?
Pro-inflammatory macrophages
What was the main finding of the ISCHEMIA trial?
Initial medical therapy is as effective as routine coronary angiography
What is the potential clinical role of 68Ga-dotatate and sodium 18F-fluoride?
Identifying inflammatory macrophages in atherosclerotic plaque
What was a limitation of the ISCHEMIA trial?
It only included patients with mild symptoms
Why is dietary manipulation necessary when using FDG?
To suppress physiological myocardial activity
Why was the specificity of stress echocardiography in women low?
Because it is not good at detecting anatomically significant coronary stenosis
What is the topic of assessment that has been developing for many years?
Myocardial viability and hibernation
What is unclear about the ISCHEMIA trial results?
Whether the results apply to patients with more significant disease
What is 68Ga-dotatate also a marker of?
Myocardial inflammation after myocardial infarction
What was a trend observed in the ISCHEMIA trial?
Towards improved outcome in patients with more severe ischaemia
What was a drawback of the routine invasive group in the ISCHEMIA trial?
It had a higher event rate due to intervention-related complications
What was the initial benefit of the routine invasive group in the ISCHEMIA trial?
An early symptomatic benefit
What is the characteristic of MRI in imaging amyloidosis?
It is unable to distinguish between AL and TTR amyloidosis
What is the main purpose of bone-seeking tracers in amyloidosis?
To image the distribution of amyloid in TTR amyloidosis
What is the name of the radionuclide tracers used to image the distribution of amyloid?
Both A and B
What is the significance of intense activity (grades 2 and 3) in diphosphonate or pyrophosphate imaging?
It perfectly distinguishes between AL and TTR cardiac amyloidosis
What is the main advantage of nuclear cardiology in imaging amyloidosis?
It provides the most common imaging test of myocardial perfusion
What is the importance of Perugini et al's study in diphosphonate or pyrophosphate imaging?
It described a system of grading myocardial activity by comparison with bone
What is the limitation of MRI in imaging cardiac amyloidosis?
It cannot distinguish between AL and TTR cardiac amyloidosis
What is the significance of 3,3-diphosphonopropano-1,2-dicarboxylic acid in imaging amyloidosis?
It is a bone-seeking tracer used for TTR amyloidosis
This quiz covers the latest developments in PET scan imaging techniques, including new tracers and their potential applications in medical imaging. Learn about the latest research and advancements in the field. Test your knowledge of PET scan imaging techniques and their uses.
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