Peripheral Nerve Regeneration Process
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Questions and Answers

What is a major component of the Schwann cell basal lamina that accelerates axonal regeneration?

  • N-cadherin
  • Thyroid hormone
  • Laminin (correct)
  • Fibronectin

What is the result of the polymerization of fibrinogen and fibronectin in nerve regeneration?

  • Formation of a gap in the nerve
  • Degeneration of the nerve
  • Formation of a fibrin matrix (correct)
  • Release of growth factors

What is a consequence of denervation on muscle tissue?

  • Muscle remains unchanged
  • Muscle undergoes rapid regeneration
  • Muscle becomes fibrotic and stiff (correct)
  • Muscle disappears

Which of the following is NOT a class of factors that enhance nerve regeneration?

<p>Vitamin supplements (B)</p> Signup and view all the answers

What is a consequence of major peripheral nerve injuries, such as brachial plexus palsy?

<p>Bone develops disuse osteoporosis (C)</p> Signup and view all the answers

How long does muscle remain viable after denervation?

<p>At least 2 years (A)</p> Signup and view all the answers

What is the outcome of wallerian degeneration on the Schwann cell basal lamina?

<p>It persists (D)</p> Signup and view all the answers

What is the role of filopodia in axonal regeneration?

<p>They are electrophilic and attach to cationic regions of the basal lamina (C)</p> Signup and view all the answers

What may occur when incompletely injured nerves are exposed to unfamiliar proteins?

<p>An autoimmune reaction is triggered (A)</p> Signup and view all the answers

What is the structure of the growth cone composed of?

<p>A structure of flattened sheets of cellular matrix (D)</p> Signup and view all the answers

WhatfillType of cells fill the endoneurial tubes during axonal regeneration?

<p>Schwann cells and macrophages (B)</p> Signup and view all the answers

What guides the regenerating axon along the basal lamina tube?

<p>The filopodia (C)</p> Signup and view all the answers

What is the primary goal of research in altering regeneration mechanisms in nerve repair?

<p>To improve results of civilian injuries with modern microsurgical technique (B)</p> Signup and view all the answers

What is the effect of gangliosides on rat sciatic nerve regeneration?

<p>Positive effects on rat sciatic nerve regeneration (C)</p> Signup and view all the answers

What is the role of immune system modulators in nerve repair?

<p>To decrease fibrosis and/or histiocytic response (B)</p> Signup and view all the answers

What is the function of forskolin in nerve regeneration?

<p>To activate adenylate cyclase and increase neurite outgrowth (C)</p> Signup and view all the answers

What is the effect of polyamines on rat sciatic nerve regeneration?

<p>Increase in the functional recovery of rat sciatic nerve (B)</p> Signup and view all the answers

What is the category of strategies to improve results of nerve repair that includes gangliosides and forskolin?

<p>Pharmacologic agents (A)</p> Signup and view all the answers

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