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Peripheral Nerve Regeneration Process

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Questions and Answers

What is a major component of the Schwann cell basal lamina that accelerates axonal regeneration?

N-cadherin

Thyroid hormone

Laminin (correct)

Fibronectin

What is the result of the polymerization of fibrinogen and fibronectin in nerve regeneration?

Formation of a gap in the nerve

Degeneration of the nerve

Formation of a fibrin matrix (correct)

Release of growth factors

What is a consequence of denervation on muscle tissue?

Muscle remains unchanged

Muscle undergoes rapid regeneration

Muscle becomes fibrotic and stiff (correct)

Muscle disappears

Which of the following is NOT a class of factors that enhance nerve regeneration?

Vitamin supplements Signup and view all the answers

What is a consequence of major peripheral nerve injuries, such as brachial plexus palsy?

Bone develops disuse osteoporosis Signup and view all the answers

How long does muscle remain viable after denervation?

At least 2 years Signup and view all the answers

What is the outcome of wallerian degeneration on the Schwann cell basal lamina?

It persists Signup and view all the answers

What is the role of filopodia in axonal regeneration?

They are electrophilic and attach to cationic regions of the basal lamina Signup and view all the answers

What may occur when incompletely injured nerves are exposed to unfamiliar proteins?

An autoimmune reaction is triggered Signup and view all the answers

What is the structure of the growth cone composed of?

A structure of flattened sheets of cellular matrix Signup and view all the answers

WhatfillType of cells fill the endoneurial tubes during axonal regeneration?

Schwann cells and macrophages Signup and view all the answers

What guides the regenerating axon along the basal lamina tube?

The filopodia Signup and view all the answers

What is the primary goal of research in altering regeneration mechanisms in nerve repair?

To improve results of civilian injuries with modern microsurgical technique Signup and view all the answers

What is the effect of gangliosides on rat sciatic nerve regeneration?

Positive effects on rat sciatic nerve regeneration Signup and view all the answers

What is the role of immune system modulators in nerve repair?

To decrease fibrosis and/or histiocytic response Signup and view all the answers

What is the function of forskolin in nerve regeneration?

To activate adenylate cyclase and increase neurite outgrowth Signup and view all the answers

What is the effect of polyamines on rat sciatic nerve regeneration?

Increase in the functional recovery of rat sciatic nerve Signup and view all the answers

What is the category of strategies to improve results of nerve repair that includes gangliosides and forskolin?

Pharmacologic agents Signup and view all the answers