Peripheral Blood Smear Anisocytosis Interpretation

Play an AI-generated podcast conversation about this lesson

What is the primary purpose of bone marrow aspirate and biopsy?

To monitor the effectiveness of chemotherapy

To determine the patient's blood type

To diagnose blood disorders and cancers (correct)

To assess lung function

Which condition is associated with hypercellular bone marrow?

Kidney Stones

Acute Megakaryoblastic Leukemia (correct)

Chronic Obstructive Pulmonary Disease

Rheumatoid Arthritis

What stain is typically used for assessing bone marrow trephine biopsy?

Masson's Trichrome Stain

Periodic Acid-Schiff (PAS) Stain

Wright Stain

Hematoxylin and Eosin (H&E) Stain (correct)

In which disease might hypocellular bone marrow be observed?

Aplastic Anemia Signup and view all the answers

Which laboratory test is most appropriate to order on a patient with a suspected hematologic disorder?

Complete blood count (CBC) Signup and view all the answers

What is the primary purpose of a peripheral blood smear (PBS) in evaluating a patient with a suspected hematologic disorder?

To evaluate blood cell characteristics Signup and view all the answers

Which laboratory test is used to identify and quantify the different types of white blood cells?

Complete blood count (CBC) Signup and view all the answers

What does a corrected reticulocyte count (CRC) measure in a patient with a suspected hematologic disorder?

Blood cell production activity Signup and view all the answers

In addition to the complete blood count (CBC), what other lab test might be indicated for a patient with a suspected hematologic disorder?

Hemoglobin electrophoresis Signup and view all the answers

What would be the next appropriate step if bone marrow examination is indicated for a patient with a suspected hematologic disorder?

Bone marrow aspirate and biopsy Signup and view all the answers

What is the best indicator of the oxygen-carrying capacity of blood?

Hemoglobin (g/dL) Signup and view all the answers

Which laboratory test is used for the evaluation of color or chromia of red blood cells and classification of anemias?

MCHC (g/dL) Signup and view all the answers

Which condition is associated with increased mean platelet volume?

Thrombocytosis Signup and view all the answers

What is the average volume of red blood cells called?

Mean cell volume (MCV) Signup and view all the answers

Which component is used for the differential count and abnormal cell morphology in a peripheral blood smear?

Abnormal WBCs Signup and view all the answers

What is the normal range for white blood cell count (WBCs) in adults?

4 - 10 x109/L Signup and view all the answers

What does decreased hemoglobin indicate?

(Dehydration) Signup and view all the answers

Which condition is associated with neutrophilia?

(Acute) inflammatory response Signup and view all the answers

What does increased lymphocyte count indicate?

(Chronic) inflammatory response Signup and view all the answers

What does decreased platelet count indicate?

Thrombocytopenia Signup and view all the answers

What is the significance of increased eosinophils?

Allergic reactions Signup and view all the answers

Which abnormal cells are evaluated in a peripheral blood smear?

Parasites like malaria, babesia, filaria Signup and view all the answers

Intravascular hemolysis is characterized by which of the following clinical features?

Low serum haptoglobin and hemoglobinemia Signup and view all the answers

Which laboratory findings are associated with extravascular hemolysis?

Elevated urobilinogen and hemosiderinuria Signup and view all the answers

Which condition is commonly associated with jaundice and splenomegaly?

Malaria-induced hemolytic anemia Signup and view all the answers

What is the main difference in the clinical presentation of intravascular and extravascular hemolysis?

Dark urine color Signup and view all the answers

Which enzyme level is typically elevated in extravascular hemolysis?

LDH Signup and view all the answers

What is the primary site of hemolysis in extravascular hemolysis?

Spleen, liver, and lymph node macrophages Signup and view all the answers

What is a characteristic morphologic finding in the blood smear of a patient with extravascular hemolysis?

Spherocytes and spur cells Signup and view all the answers

Which urinary finding is associated with intravascular hemolysis?

Cola-colored urine Signup and view all the answers

What is a common symptom associated with both intravascular and extravascular hemolysis?

Jaundice Signup and view all the answers

Which clinical feature distinguishes intravascular from extravascular hemolysis?

Dark urine color Signup and view all the answers

What is the primary mechanism of destruction of red blood cells in intravascular hemolysis?

Immune destruction by spleen macrophages Signup and view all the answers

Which enzyme level is typically elevated in intravascular hemolysis?

AST Signup and view all the answers

What is the classification of anemias based on RBC size?

Normocytic, e.g., iron-deficiency anemia and thalassemia Signup and view all the answers

What are spherocytes?

Spherical RBCs with normal MCV, MCH, and MCHC Signup and view all the answers

Which stain is used to identify immature RBCs in a peripheral blood smear?

Wright-Giemsa stain Signup and view all the answers

What is the marker of erythropoietic activity?

Reticulocyte count (RC) Signup and view all the answers

Where does extravascular hemolysis primarily occur?

Within the macrophages of the spleen, liver, and lymph nodes Signup and view all the answers

What is the clinical feature associated with intravascular hemolysis?

Jaundice Signup and view all the answers

Which stain is used to assess reticulocytes in human blood?

Supravital new methylene blue stain Signup and view all the answers

What is the average volume of red blood cells called?

$MCV$ Signup and view all the answers

What distinguishes spherocytes from normal RBCs?

Shape and color intensity Signup and view all the answers

Which enzyme level is typically elevated in extravascular hemolysis?

Lactate dehydrogenase (LDH) level Signup and view all the answers

What are polychromatophilic or orthochromic macrocytes indicative of?

Erythropoietic activity Signup and view all the answers

What does a high reticulocyte count indicate?

Erythropoietic activity Signup and view all the answers

Peripheral Blood Smear Anisocytosis Interpretation

Choose a study mode

Podcast

Questions and Answers

What is the primary purpose of bone marrow aspirate and biopsy?

Which condition is associated with hypercellular bone marrow?

What stain is typically used for assessing bone marrow trephine biopsy?

In which disease might hypocellular bone marrow be observed?

Which laboratory test is most appropriate to order on a patient with a suspected hematologic disorder?

What is the primary purpose of a peripheral blood smear (PBS) in evaluating a patient with a suspected hematologic disorder?

Which laboratory test is used to identify and quantify the different types of white blood cells?

What does a corrected reticulocyte count (CRC) measure in a patient with a suspected hematologic disorder?

In addition to the complete blood count (CBC), what other lab test might be indicated for a patient with a suspected hematologic disorder?

What would be the next appropriate step if bone marrow examination is indicated for a patient with a suspected hematologic disorder?

What is the best indicator of the oxygen-carrying capacity of blood?

Which laboratory test is used for the evaluation of color or chromia of red blood cells and classification of anemias?

Which condition is associated with increased mean platelet volume?

What is the average volume of red blood cells called?

Which component is used for the differential count and abnormal cell morphology in a peripheral blood smear?

What is the normal range for white blood cell count (WBCs) in adults?

What does decreased hemoglobin indicate?

Which condition is associated with neutrophilia?

What does increased lymphocyte count indicate?

What does decreased platelet count indicate?

What is the significance of increased eosinophils?

Which abnormal cells are evaluated in a peripheral blood smear?

Intravascular hemolysis is characterized by which of the following clinical features?

Which laboratory findings are associated with extravascular hemolysis?

Which condition is commonly associated with jaundice and splenomegaly?

What is the main difference in the clinical presentation of intravascular and extravascular hemolysis?

Which enzyme level is typically elevated in extravascular hemolysis?

What is the primary site of hemolysis in extravascular hemolysis?

What is a characteristic morphologic finding in the blood smear of a patient with extravascular hemolysis?

Which urinary finding is associated with intravascular hemolysis?

What is a common symptom associated with both intravascular and extravascular hemolysis?

Which clinical feature distinguishes intravascular from extravascular hemolysis?

What is the primary mechanism of destruction of red blood cells in intravascular hemolysis?

Which enzyme level is typically elevated in intravascular hemolysis?

What is the classification of anemias based on RBC size?

What are spherocytes?

Which stain is used to identify immature RBCs in a peripheral blood smear?

What is the marker of erythropoietic activity?

Where does extravascular hemolysis primarily occur?

What is the clinical feature associated with intravascular hemolysis?

Which stain is used to assess reticulocytes in human blood?

What is the average volume of red blood cells called?

What distinguishes spherocytes from normal RBCs?

Which enzyme level is typically elevated in extravascular hemolysis?

What are polychromatophilic or orthochromic macrocytes indicative of?

What does a high reticulocyte count indicate?

More Like This

Blood Film Examination

W1-9 Principles of hematology

RBC and WBC Morphology Quiz: Identify Blood Cell Types

Peripheral Blood Smear Quiz & Flashcards