Peripheral Blood Smear Anisocytosis Interpretation

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Questions and Answers

What is the primary purpose of bone marrow aspirate and biopsy?

  • To monitor the effectiveness of chemotherapy
  • To determine the patient's blood type
  • To diagnose blood disorders and cancers (correct)
  • To assess lung function

Which condition is associated with hypercellular bone marrow?

  • Kidney Stones
  • Acute Megakaryoblastic Leukemia (correct)
  • Chronic Obstructive Pulmonary Disease
  • Rheumatoid Arthritis

What stain is typically used for assessing bone marrow trephine biopsy?

  • Masson's Trichrome Stain
  • Periodic Acid-Schiff (PAS) Stain
  • Wright Stain
  • Hematoxylin and Eosin (H&E) Stain (correct)

In which disease might hypocellular bone marrow be observed?

<p>Aplastic Anemia (C)</p> Signup and view all the answers

Which laboratory test is most appropriate to order on a patient with a suspected hematologic disorder?

<p>Complete blood count (CBC) (A)</p> Signup and view all the answers

What is the primary purpose of a peripheral blood smear (PBS) in evaluating a patient with a suspected hematologic disorder?

<p>To evaluate blood cell characteristics (D)</p> Signup and view all the answers

Which laboratory test is used to identify and quantify the different types of white blood cells?

<p>Complete blood count (CBC) (C)</p> Signup and view all the answers

What does a corrected reticulocyte count (CRC) measure in a patient with a suspected hematologic disorder?

<p>Blood cell production activity (A)</p> Signup and view all the answers

In addition to the complete blood count (CBC), what other lab test might be indicated for a patient with a suspected hematologic disorder?

<p>Hemoglobin electrophoresis (A)</p> Signup and view all the answers

What would be the next appropriate step if bone marrow examination is indicated for a patient with a suspected hematologic disorder?

<p>Bone marrow aspirate and biopsy (D)</p> Signup and view all the answers

What is the best indicator of the oxygen-carrying capacity of blood?

<p>Hemoglobin (g/dL) (D)</p> Signup and view all the answers

Which laboratory test is used for the evaluation of color or chromia of red blood cells and classification of anemias?

<p>MCHC (g/dL) (C)</p> Signup and view all the answers

Which condition is associated with increased mean platelet volume?

<p>Thrombocytosis (D)</p> Signup and view all the answers

What is the average volume of red blood cells called?

<p>Mean cell volume (MCV) (A)</p> Signup and view all the answers

Which component is used for the differential count and abnormal cell morphology in a peripheral blood smear?

<p>Abnormal WBCs (B)</p> Signup and view all the answers

What is the normal range for white blood cell count (WBCs) in adults?

<p>4 - 10 x109/L (D)</p> Signup and view all the answers

What does decreased hemoglobin indicate?

<p>(Dehydration) (D)</p> Signup and view all the answers

Which condition is associated with neutrophilia?

<p>(Acute) inflammatory response (A)</p> Signup and view all the answers

What does increased lymphocyte count indicate?

<p>(Chronic) inflammatory response (D)</p> Signup and view all the answers

What does decreased platelet count indicate?

<p>Thrombocytopenia (C)</p> Signup and view all the answers

What is the significance of increased eosinophils?

<p>Allergic reactions (D)</p> Signup and view all the answers

Which abnormal cells are evaluated in a peripheral blood smear?

<p>Parasites like malaria, babesia, filaria (C)</p> Signup and view all the answers

Intravascular hemolysis is characterized by which of the following clinical features?

<p>Low serum haptoglobin and hemoglobinemia (D)</p> Signup and view all the answers

Which laboratory findings are associated with extravascular hemolysis?

<p>Elevated urobilinogen and hemosiderinuria (B)</p> Signup and view all the answers

Which condition is commonly associated with jaundice and splenomegaly?

<p>Malaria-induced hemolytic anemia (A)</p> Signup and view all the answers

What is the main difference in the clinical presentation of intravascular and extravascular hemolysis?

<p>Dark urine color (B)</p> Signup and view all the answers

Which enzyme level is typically elevated in extravascular hemolysis?

<p>LDH (A)</p> Signup and view all the answers

What is the primary site of hemolysis in extravascular hemolysis?

<p>Spleen, liver, and lymph node macrophages (D)</p> Signup and view all the answers

What is a characteristic morphologic finding in the blood smear of a patient with extravascular hemolysis?

<p>Spherocytes and spur cells (D)</p> Signup and view all the answers

Which urinary finding is associated with intravascular hemolysis?

<p>Cola-colored urine (D)</p> Signup and view all the answers

What is a common symptom associated with both intravascular and extravascular hemolysis?

<p>Jaundice (A)</p> Signup and view all the answers

Which clinical feature distinguishes intravascular from extravascular hemolysis?

<p>Dark urine color (C)</p> Signup and view all the answers

What is the primary mechanism of destruction of red blood cells in intravascular hemolysis?

<p>Immune destruction by spleen macrophages (A)</p> Signup and view all the answers

Which enzyme level is typically elevated in intravascular hemolysis?

<p>AST (C)</p> Signup and view all the answers

What is the classification of anemias based on RBC size?

<p>Normocytic, e.g., iron-deficiency anemia and thalassemia (A)</p> Signup and view all the answers

What are spherocytes?

<p>Spherical RBCs with normal MCV, MCH, and MCHC (C)</p> Signup and view all the answers

Which stain is used to identify immature RBCs in a peripheral blood smear?

<p>Wright-Giemsa stain (B)</p> Signup and view all the answers

What is the marker of erythropoietic activity?

<p>Reticulocyte count (RC) (D)</p> Signup and view all the answers

Where does extravascular hemolysis primarily occur?

<p>Within the macrophages of the spleen, liver, and lymph nodes (D)</p> Signup and view all the answers

What is the clinical feature associated with intravascular hemolysis?

<p>Jaundice (C)</p> Signup and view all the answers

Which stain is used to assess reticulocytes in human blood?

<p>Supravital new methylene blue stain (B)</p> Signup and view all the answers

What is the average volume of red blood cells called?

<p>$MCV$ (A)</p> Signup and view all the answers

What distinguishes spherocytes from normal RBCs?

<p>Shape and color intensity (B)</p> Signup and view all the answers

Which enzyme level is typically elevated in extravascular hemolysis?

<p>Lactate dehydrogenase (LDH) level (A)</p> Signup and view all the answers

What are polychromatophilic or orthochromic macrocytes indicative of?

<p>Erythropoietic activity (D)</p> Signup and view all the answers

What does a high reticulocyte count indicate?

<p>Erythropoietic activity (A)</p> Signup and view all the answers

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